A5101774180- Nanoplatforms for cancer theranostics
- Luminescence and Fluorescent Materials
- Advanced biosensing and bioanalysis techniques
- Reproductive Biology and Fertility
- Air Quality Monitoring and Forecasting
- Vehicle emissions and performance
- Molecular Sensors and Ion Detection
- Atmospheric and Environmental Gas Dynamics
- RNA Interference and Gene Delivery
- Analytical Chemistry and Sensors
- Selenium in Biological Systems
- Angiogenesis and VEGF in Cancer
- Cancer, Hypoxia, and Metabolism
- Mercury impact and mitigation studies
- Air Quality and Health Impacts
- Mechanics and Biomechanics Studies
- Fibroblast Growth Factor Research
- Biomarkers in Disease Mechanisms
- Single-cell and spatial transcriptomics
- Bone Tissue Engineering Materials
- DNA and Nucleic Acid Chemistry
- Electron Spin Resonance Studies
- Cancer Treatment and Pharmacology
- Reproductive System and Pregnancy
- Gold and Silver Nanoparticles Synthesis and Applications
Huazhong University of Science and Technology
2024-2025
Tongji Hospital
2023-2025
Hubei University of Technology
2023-2024
The First People's Hospital of Changde
2024
National Clinical Research Center for Digestive Diseases
2024
Ministry of Education of the People's Republic of China
2024
Weatherford College
2024
Zhejiang Ocean University
2023-2024
Shanghai Jiao Tong University
2023
Hubei University
2023
Abstract Limited understanding exists regarding how aging impacts the cellular and molecular aspects of human ovary. This study combines single-cell RNA sequencing spatial transcriptomics to systematically characterize ovarian aging. Spatiotemporal signatures eight types cells during are observed. An analysis age-associated changes in gene expression reveals that DNA damage response may be a key biological pathway oocyte Three granulosa subtypes five theca stromal subtypes, as well their...
Nonobstructive azoospermia (NOA) is an important cause of infertility, and intracytoplasmic sperm injection (ICSI) the mainstay treatment for these patients. In cases where a sufficient number (usually 1–2) not available, selection oocytes ICSI difficult problem that must be solved. Here, we constructed dual-activated oxidative stress-responsive AIE probe, b-PyTPA. The strong donor–acceptor configuration b-PyTPA leads to twisted intramolecular charge transfer (TICT) effect quenches...
Fluorescence imaging-guided navigation for cancer surgery has a promising clinical application. However, pan-cancer encompasses wide variety of types with significant heterogeneity, resulting in the lack universal and highly contrasted fluorescent probes surgical navigation. Here, we developed an aggregation-induced emission (AIE) probe (MI-AIE-TsG, MAT) dual activation MAT weakly activates fluorescence by targeting SUR1 protein on endoplasmic reticulum (ER) through TsG group. Subsequently,...
The utilization of Near Infrared (NIR) laser-excited phototheranostic agents has demonstrated potential for enhancing phototherapy deep-seated tumors. However, many NIR have exhibited weak photoluminescence intensity, making it challenging to obtain clear fluorescence imaging. To address this issue, a series ternary copolymers containing triphenylamine, carbazole, and benzobisthiadiazole on the mainchain are synthesized. main focus is evaluate influence varying proportions structural units...
Hypochlorous acid exists as HClO in acidic conditions and ClO– alkaline conditions, posing a significant challenge for differentiation due to their strong closely similar oxidative reaction activities. Addressing this challenge, our study presents an asymmetric donor–acceptor–donor′ (D–A–D′) molecular architecture the design of fluorescent probe (PMT NPs) that demonstrates exceptionally high specificity toward alongside optimized ratiometric response. The incorporation electron acceptor...
Phototherapy, renowned for its noninvasiveness, is widely employed in tumor treatment. However, the microenvironment usually hypoxic, with insufficient reactive oxygen species (ROS) production, severely limiting application. Herein, we introduce a regio-isomerization optimization strategy and have synthesized four regio-isomeric photosensitizers featuring donor–acceptor (D–A) configuration by tactically varying linkage sites between D A. Among them, TAF-3 excellent photostability has an...
A neutral phosphorescent coordination compound bearing a benzimidazole ligand, Ir(pbi)2(acac) (Hpbi = 1,2-diphenyl-1H-benzo[d]imidazole; Hacac acetylacetone), is demonstrated to be the first example of sulfur-free iridium complex for detection Hg2+ cations with high selectivity and sensitivity. shows multisignaling response towards mercury(II) ions through UV-vis absorption, phosphorescence electrochemistry measurements. Upon addition ions, solutions this change from yellow colorless, which...
Small molecular neutral Ir(III) complexes have been demonstrated to be promising self-inclusive microcrystalline thin-film oxygen sensors with relatively high sensitivity (Ksv = 6.41), good stability, and linear Stern-Volmer behavior (R(2) 0.9979).
Cuproptosis is a type of metabolic cell death and exhibits great potential for cancer treatment. However, currently, most cuproptosis-based therapies are primarily effective in tumor cells reliant on mitochondrial respiration, limiting their broader application. The Warburg effect highlights that many tumors predominantly rely glycolysis to meet rapid demands, but glycolysis-dependent less sensitive copper ions than mitochondrial-respiration-dependent counterparts, making it difficult induce...
Abstract Nanopores offer significant advantages in biosensing. Conventional nanopore sensors require probe modification within the pore, and there are two major obstacles: inhomogeneity of distortion detection signal due to uncontrollable dynamics target pore. Here, we constructed a cell‐sensing analogue (CeSa‐nanopore), by coating outer surface with cell membrane. The kinetics target‐probe binding were also addressed. Specific cells selected prepare CeSa‐nanopore, for example, high...
a 黄艳 卢志云 * ,a ( 四川大学 化学学院 成都 610064)色坐标分别为(0.61,0.39)和(0.62,0.38).相比之下, 以母体化合物(Nbt) 2 Ir(acac)为发光客体材料所制备的参比器件, 其最大发光亮度则为 1620 cd•m -2 , 最大电流效率仅为 1.5 cd•A -1 CIE1931 色坐标为(0.59,0.41).上述研究结果表明: 向 C-Ir 键对位进行苯基修饰可以在提高铱(III)配合物的 可溶液加工性能的同时, 获得更为红移的电致发光波长, 是一种简单而有效的红光铱(III)配合物的分子设计策略.
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To investigate the impact of RDW/CA (the ratio red cell distribution width to calcium) on in-hospital mortality in patients with acute respiratory failure (ARF). This retrospective cohort study analyzed data 6981 ARF from Medical Information Mart for Intensive Care (MIMIC-IV) database 2.0. Critically ill participants between 2008 and 2019 at Beth Israel Deaconess Center Boston. The primary outcome interest was mortality. A Cox proportional hazards regression model used determine whether...
Abstract Molecular spherical nucleic acids (m‐SNAs) are a second generation of (SNAs), which significance in potential application targeted delivery or gene regulation due to their defined molecular structures. Nevertheless, m‐SNAs typically involve single DNA sequence greatly limits its functions as either targeting purpose regulation. In response, we proposed here third generation, supramolecular (Supra‐SNAs) with two different sequences achieve both above‐mentioned functions....
Because of the insidious nature lymphatic metastatic cancer, accurate imaging tracing is very difficult to achieve in clinic. Previous studies have developed LARGR peptide (named TMVP1) as a radiotracer for vascular endothelial growth factor receptor-3 (VEGFR-3) cancer. However, its affinity target remains insufficient, resulting low sensitivity. In this study, we identified high-affinity VEGFR-3 targeting peptide, named TMVP1446, using multiplex screening platform. TMVP1446 demonstrated...
Selenium is an essential trace element for human health. To date, a hotspot of functional foods strengthening the content organic Se in food using biological enrichment. Herein, Se-enriched rice pancakes were produced by directly adding different sodium selenite concentrations into fermentation process. The effects addition on texture properties, structure, and species investigated. Meanwhile, bioaccessibility changes determined digestion experiments vitro. results showed significant...
The morphology of Au-decorated ZnO nanorods and the two-photon excitation process this as-prepared composite material are explored by C. X. Xu co-workers. As demonstrated on page 940, excited UV emission can be significantly enhanced under an 520 nm, consistent with localized surface plasmon resonance (LSPR) peak Au nanoparticles (NPs). This improvement is attributed to strong local field enhancement generated LSPR NPs.