A5043932514- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Endometrial and Cervical Cancer Treatments
- Ovarian cancer diagnosis and treatment
- Cervical Cancer and HPV Research
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Cancer Mechanisms and Therapy
- Endometriosis Research and Treatment
- RNA Research and Splicing
- Cancer, Hypoxia, and Metabolism
- PI3K/AKT/mTOR signaling in cancer
- Cancer, Lipids, and Metabolism
- Reproductive System and Pregnancy
- Uterine Myomas and Treatments
- Gynecological conditions and treatments
- Cytokine Signaling Pathways and Interactions
- Extracellular vesicles in disease
- Sulfur-Based Synthesis Techniques
- Estrogen and related hormone effects
- Lung Cancer Research Studies
- Cancer-related gene regulation
- Urological Disorders and Treatments
- Growth Hormone and Insulin-like Growth Factors
First Affiliated Hospital of Zhengzhou University
2016-2025
Jilin University
2025
Helix (United States)
2024
Shijiazhuang University
2013-2024
Tianjin Medical University
2024
China Academy of Space Technology
2023
Taiyuan Central Hospital
2020
Shanxi Medical University
2017-2020
Zhengzhou University
2019
Hebei Medical University
2013-2015
The long noncoding RNA homeobox (HOX) transcript antisense intergenic (HOTAIR) has been demonstrated to be a vital modulator in the proliferation and metastasis of ovarian cancer cells, but its potential molecular mechanism remains elucidated. In current study, we aimed uncover biological role lncRNA HOTAIR underlying regulatory progression cancer.HOTAIR expression was detected by quantitative RT-PCR (qRT-PCR) northern blotting. SKOV3 cell line chosen for subsequent assays. addition, mRNA...
Autophagy, characterized by the elevator of autophagy-related gene 14 (ATG14) and dysregulation proteins, contributes to cisplatin (DDP) resistance in ovarian cancer. Forkhead box protein P1 (FOXP1), which is a well-defined transcription factor, reported have oncogenic effect on This study aims identify miR-29c-3p/FOXP1/ATG14 pathway regulating autophagy DDP The expressions miR-29c-3p, FOXP1, ATG14 proteins were detected DDP-sensitive cancer cell lines (SKOV3 A2780) DDP-resistant (SKOV3/DDP...
Abstract Background and Objective: The occurrence of diabetic ketoacidosis (DKA) during pregnancy is considered a medical emergency. aims the present study were to evaluate incidence DKA in pregnant non‐pregnant women with diabetes; compare blood glucose levels at diagnosis women; show case euglycemic pregnancy. Methods: subjects consisted 90 cases diabetes 286 female inpatients receiving treatment for 2001 2005 our hospital. compared. Results: had higher (8/90, 8.9%) than (9/286, 3.1%) ( P...
To investigate the mechanism of LncRNA H19 in Th17 cell differentiation and endometrial stromal cells (ESCs) proliferation endometriosis (EMS).LncRNA H19, miR-342-3p IER3 expressions were detected by qRT-PCR western blot. The percentage cells/CD4+ T was flow cytometry. IL-17 level measured ELISA. interaction confirmed Luciferase reporter assay.LncRNA down-regulated mononuclear from peritoneal fluid (PFMCs) patients with EMS or under conditions, whereas expression up-regulated increased PFMCs...
Cervical cancer (CC) is the fourth most frequent malignancy among women worldwide, and its prevention treatment are evolving rapidly. The gut microbiota has been reported to play a crucial role both in preservation of homeostasis development cervical cancer. In this study, we collected fecal samples investigate microbial signatures patients compared with healthy controls using 16S rRNA sequencing analysis metagenomic next-generation (mNGS) testing. Our findings demonstrated substantial...
ObjectiveTo evaluate the prognosis and fertility of patients with stage II-IV borderline ovarian tumors who underwent fertility-sparing surgery.MethodsThis retrospective single-institution study included under age 40 years at First Affiliated Hospital Zhengzhou University between January 2007 March 2023. Disease-free survival was main outcome. The association disease-free assessed using Kaplan‒Meier Cox proportional hazards methods.ResultsA total 144 were in this study. Based on whether...
AKT plays an important role in malignant behavior of tumors. The purpose the present study was to determine expression phosphorylated (P‐AKT) and nuclear factor‐κB (NF‐κB) p65 their association with clinicopathological parameters prognosis epithelial ovarian tumor. On immunohistochemistry 115 samples tissue that included 68 specimens cancer, 12 borderline tumor, 24 benign tumor 11 normal ovary, were evaluated. Sixty‐three patients cancer followed up from 7 months. positive rate P‐AKT NF‐κB...
Aim: The aim of this study was to determine if HOTAIR rs920778 polymorphism is associated with ovarian cancer susceptibility and prognosis. Materials & methods: data were obtained from two independent groups including 329 patients 680 cancer-free, age-matched women. Blood samples collected genomic DNA extracted for genotyping. Results: TT genotype T allele significantly a decreased risk (p = 0.0004 p < 0.0001, respectively), which advanced tumor stage, lymph node metastasis poor Moreover, TC...
Cisplatin (DDP) is a major chemotherapeutic drug which was widely used for cervical cancer (CC) patients with advanced or recurrent although its limitation in the development of resistance. LncRNA nicotinamide nucleotide transhydrogenase-antisense RNA1 (NNT-AS1) has been reported to be involved DDP However, role NNT-AS1 resistance CC remain unknown.The mRNA expression NNT-AS1, microRNA-186 (miR-186) and HMGB1 detected by quantitative real-time polymerase chain reaction (qRT-PCR). Cell...
Abstract Aldolase A (ALDOA) is an enzyme that plays important role in glycolysis and gluconeogenesis, which closely related to tumor metabolism. In this study, the overall roles of ALDOA pan-cancer have been investigated from several aspects using databases online analysis tools. Using ONCOMINE database, expression various cancers was analyzed. The prognostic explored by PrognoScan, GEPIA, Kaplan–Meier Plotter. immune-related its downstream substrates decided TIMER, cBioPortal String. Our...
Objective The goal of this study was to investigate the effect G protein–coupled receptor 30 (GPR30) on activation PI3K/Akt pathway induced by E2 in endometrial cancer cells. Methods and materials Immunohistochemistry performed determine location expression GPR30, estrogen receptors (ERs), Akt, phosphorylated Akt. We also investigated ERs, level phosphorylation Akt cells, Ishikawa HEC-1A down-regulated GPR30 cell lines transfection with shGPR30-pGFP-V-RS, a antisense vector. cells were then...
Endometrial cancer (EC) is one of the most commonly diagnosed gynecologic malignancies in world, with morbidity rate over 7%. The mechanism pathogenesis has not been specifically elucidated to date, which imperative for EC treatment. aim our study was investigate target relationship between miR-143 and mitogen-activated protein kinase 1 (MAPK1) explore effect on endometrial cancers cells through targeting MAPK1. We collected tissues adjacent tissues, transfected mimics MAPK1 siRNA into...