A5046755591- MicroRNA in disease regulation
- Circular RNAs in diseases
- Extracellular vesicles in disease
- RNA Research and Splicing
- Cancer-related molecular mechanisms research
- Peptidase Inhibition and Analysis
- Adenosine and Purinergic Signaling
- Cancer Immunotherapy and Biomarkers
- Gynecological conditions and treatments
- Chemokine receptors and signaling
- Colorectal Cancer Screening and Detection
- Cancer Mechanisms and Therapy
- Gastric Cancer Management and Outcomes
- Surgical Simulation and Training
- Endometriosis Research and Treatment
- Renal and related cancers
- Uterine Myomas and Treatments
- Reproductive System and Pregnancy
- Cancer Cells and Metastasis
- Intestinal and Peritoneal Adhesions
- Bladder and Urothelial Cancer Treatments
- Lung Cancer Treatments and Mutations
- Lung Cancer Research Studies
- Radiomics and Machine Learning in Medical Imaging
- Cholangiocarcinoma and Gallbladder Cancer Studies
First Affiliated Hospital of Zhengzhou University
2018-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2023
Beijing Proteome Research Center
2022-2023
The long noncoding RNA homeobox (HOX) transcript antisense intergenic (HOTAIR) has been demonstrated to be a vital modulator in the proliferation and metastasis of ovarian cancer cells, but its potential molecular mechanism remains elucidated. In current study, we aimed uncover biological role lncRNA HOTAIR underlying regulatory progression cancer.HOTAIR expression was detected by quantitative RT-PCR (qRT-PCR) northern blotting. SKOV3 cell line chosen for subsequent assays. addition, mRNA...
Cervical cancer (CC) is the fourth most frequent malignancy among women worldwide, and its prevention treatment are evolving rapidly. The gut microbiota has been reported to play a crucial role both in preservation of homeostasis development cervical cancer. In this study, we collected fecal samples investigate microbial signatures patients compared with healthy controls using 16S rRNA sequencing analysis metagenomic next-generation (mNGS) testing. Our findings demonstrated substantial...
Background: Intravenous leiomyomatosis (IVL) is a rare benign smooth muscle tumor, for which the ultrasound features and diagnostic value have rarely been reported due to its infrequent presentation. This study aimed analyze ultrasonographic characteristics of uterine IVL explore risk factors influencing postoperative recurrence. Methods: A retrospective analysis was conducted 61 patients who underwent surgical treatment from December 2014 2023. Intraoperative or pathology confirmed in these...
Mesothelin (MSLN) is a glycoprotein with various expression degrees in different tumors including mesothelioma, ovarian cancer, pancreatic etc. MSLN considered to play an important role cell survival, proliferation, and tumor progression. Although the of makes it potential therapeutic target, its mechanism action still unclear, especially correlation immune cells infiltration microenvironment has not been investigated. In this study, we detected overexpression cancer using database analysis...
Radiotherapy is widely used in treating cervical cancer patients, however, radioresistance unavoidably occurs and seriously affects the treatment effect. It well known that hypoxia plays an important role promoting tumor microenvironment, yet our understanding of effect small extracellular vesicles miRNA on radiosensitivity hypoxic environment still limited.Small extracted from normoxic cultured cells were evaluated for their effects radioresistance. miR-152-3p was found to be a potential...
Endoscopic surgery is increasingly utilized for the treatment of early gastric cancer (EGC) worldwide, whereas lymph node metastasis (LNM) remains a critical risk factor relapse EGC after endoscopic surgery. Therefore, identifying potential predictive factors and understanding molecular mechanisms are urgently needed improving outcome patients with LNM. UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE) key enzyme in process biosynthesis CMP-Neu5Ac from (UDP-GlcNAc), which...
5530 Background: Anlotinib, a small molecule antiangiogenic drug, which can inhibit multiple tyrosine kinase receptor activity, had been proven effective and well-tolerant in patients with recurrent or metastatic cervical cancer who received two more lines of prior treatments. AK105 is novel human immunoglobulin G1 (IgG1) anti-programmed cell death-1 (PD-1) antibody. This single-arm, phase Ⅱ clinical trial aimed to assess the efficacy safety plus anlotinib as fist-line therapy for...
Despite encouraging results from immunotherapy combined with targeted therapy for hepatocellular carcinoma (HCC), the prognosis remains poor. Chemokines and their receptors are an essential component in development of HCC, but significance HCC have not yet been fully elucidated. We aimed to establish chemokine-related prognostic signature investigate association between genes tumor immune microenvironment (TIME).342 patients screened TCGA cohort. A was developed using least absolute...
Abstract Background : Leucyl And Cystinyl Aminopeptidase (LNPEP) encodes a zinc-dependent aminopeptidase, which has been proved to participate in the vesicle-mediated transport and class I major histocompatibility complex-mediated antigen processing presentation. However, function of LNPEP tumor immune microenvironment ovarian cancer (OV) its potential molecular mechanisms have not elucidated. Material Methods To analyze expression profile, prognostic value, infiltration LNPEP,...
Ovarian cancer is one of the most common cause death in women due to its late diagnosis and susceptibility drug resistance. Adenosine (ADO) signaling plays a key role immune activity tumor progression. In this study, we constructed signature ADO metabolism related genes expression patients with ovarian cancer.A total 372 from TCGA was used as training set 1,137 six GEO datasets were validation set. The gene response inhibitory concentration values for cell line GDSC sensitivity analysis....
Objective To study the clinical use of indocyanine green (ICG) fluorescence imaging in laparoscopic liver surgery. Methods The and pathological data 68 patients who underwent la-paroscopic hepatectomy using ICG technique during period from September 2016 to October 2018 Zhongnan Hospital, Wuhan University were retrospectively analyzed. Analysis was carried out on surgical methods, navigation injection time dose, tumor characteristics, studies resected specimens. Results Of...
Objective To explore the application value of three-dimensional (3D) visualization combined with intraoperative indocyanine green (ICG) fluorescence imaging in laparoscopic hepatectomy for primary liver cancer (PLC). Methods Clinical data 51 patients PLC who underwent using 3D ICG Zhongnan Hospital Wuhan University from June 2017 to 2018 were retrospectively analyzed. Among them, 24 male and 27 female, aged (57±15) years on average. The informed consents all obtained local ethical...
Abstract Background Extracellular vesicle (EV) that delivered microRNAs (miRNAs) have been found as the important biomarkers participating in pathological mechanism of ovarian cancer. Consequently, this study sought to examine underlying mesenchymal stem cell (MSC)-derived EVs containing miR-4488 Methods The normal tissues and cancer were extracted, information MSC-EV miRNA was obtained by Bioinformatics analysis. RT-qPCR western blot analysis applied detect α/β-hydrolase domain-containing...