A5051936426- Extracellular vesicles in disease
- MicroRNA in disease regulation
- Colorectal Cancer Screening and Detection
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Hemostasis and retained surgical items
- Gut microbiota and health
- Silk-based biomaterials and applications
- Electrohydrodynamics and Fluid Dynamics
- Cancer-related molecular mechanisms research
- Phytochemistry and Bioactive Compounds
- Therapeutic Uses of Natural Elements
- Cell Adhesion Molecules Research
- Reproductive System and Pregnancy
- Traditional and Medicinal Uses of Annonaceae
- Osteoarthritis Treatment and Mechanisms
- Mesenchymal stem cell research
- Nanoplatforms for cancer theranostics
- RNA Interference and Gene Delivery
- Ethics in Clinical Research
- Phytochemical Studies and Bioactivities
- Phagocytosis and Immune Regulation
First Affiliated Hospital of Zhengzhou University
2022-2023
Central South University
2019-2023
Yale University
2023
Hubei Polytechnic University
2021
Beijing Institute of Technology
2011
The CD47/PD-L1 antibodies combination exhibits durable antitumor immunity but also elicits excessive immune-related adverse events (IRAEs) caused by the on-target off-tumor immunotoxicity, hindering their clinical benefits greatly. Here, a microfluidics-enabled nanovesicle using ultra-pH-sensitive polymer mannose-poly(carboxybetaine methacrylate)-poly(hydroxyethyl piperidine methacrylate) (Man-PCB-PHEP) is developed to deliver (NCPA) for tumor-acidity-activated immunotherapy. NCPA can...
Cervical cancer (CC) is the fourth most frequent malignancy among women worldwide, and its prevention treatment are evolving rapidly. The gut microbiota has been reported to play a crucial role both in preservation of homeostasis development cervical cancer. In this study, we collected fecal samples investigate microbial signatures patients compared with healthy controls using 16S rRNA sequencing analysis metagenomic next-generation (mNGS) testing. Our findings demonstrated substantial...
We report an enantioselective synthesis of anhydrogukulenin A C2-acetate (31), a potential precursor to the antiproliferative bis(tropolone) metabolites known as gukulenins. Key steps in synthetic sequence include directed C–H arylation exo-2-norbornyl picolinamide using hindered, electron-rich arene coupling partner, tandem Grob fragmentation–diastereoselective α-methylation establish highly-substituted cyclopentane rings target, novel one-carbon ring expansion α-iodo-ortho-benzoquinone...
Abstract Background A biobank is a storage facility which stores sample mainly for biological or medical researches. Biospecimen collection the kind of work essential in building biobank. However, we found works had difficulties proceeding because low anticipation rate. Methods We here conducted questionnaire including several questions covered aspects order to find out people’s attitude towards biospecimen donation. The 20 focused on overall publics’ participation rates, matters that...