A5050887292- Pancreatic function and diabetes
- Diabetes Treatment and Management
- Metabolism, Diabetes, and Cancer
- Diabetes Management and Research
- Pluripotent Stem Cells Research
- Diabetes and associated disorders
- Insect-Plant Interactions and Control
- CRISPR and Genetic Engineering
- Air Quality and Health Impacts
- Extracellular vesicles in disease
- Insect symbiosis and bacterial influences
- Tissue Engineering and Regenerative Medicine
- MicroRNA in disease regulation
- Insect Resistance and Genetics
- Reproductive Biology and Fertility
- Climate Change and Health Impacts
- Cancer, Hypoxia, and Metabolism
- Fibroblast Growth Factor Research
- Mesenchymal stem cell research
- Sperm and Testicular Function
- Liver Disease Diagnosis and Treatment
- FOXO transcription factor regulation
- Genetics, Aging, and Longevity in Model Organisms
- Autophagy in Disease and Therapy
- Congenital heart defects research
China Agricultural University
2021-2025
Peking University Third Hospital
2016-2025
Peking University
2016-2025
Sichuan University
2023-2025
University of Hong Kong
2017-2024
Shijiazhuang University
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2023-2024
Kunming Medical University
2024
Xiyuan Hospital
2023-2024
Huazhong University of Science and Technology
2024
Early diagnosis of colon cancer (CC) is clinically important, as it can significantly improve patients' survival rate and quality life. Although the potential role for small extracellular vesicles (sEVs) in early detection many diseases has been repeatedly mentioned, systematic screening plasma sEVs derived CC specific biomarkers not yet reported. In this work, enriched fractions were from 15 early-stage (TisN0M0) patients 10 normal controls (NC). RNA sequencing identified a total number 95...
The aim of this study was to explore the intracellular mechanisms underlying cardiovascular toxicity air particulate matter (PM) with an aerodynamic diameter less than 2.5 µm (PM2.5) in a human umbilical vein cell line, EA.hy926. We found that PM2.5 exposure triggered reactive oxygen species (ROS) generation, resulting significant decrease viability. Data from Western blots showed induced phosphorylation Jun N-terminal kinase (JNK), extracellular signal regulatory (ERK), p38...
<h3>Importance</h3> Presence of thyroid autoantibodies in women with normal function is associated increased risk miscarriage. Whether levothyroxine treatment improves pregnancy outcomes among undergoing vitro fertilization and embryo transfer (IVF-ET) unknown. <h3>Objective</h3> To determine the effect on miscarriage IVF-ET who had tested positive for autoantibodies. <h3>Design, Setting, Participants</h3> An open-label, randomized clinical trial involving 600 antithyroperoxidase antibody...
Abstract Background Identifying reliable prognostic markers is crucial for the effective management of hypertension. The neutrophil-to-lymphocyte ratio (NLR) has emerged as a potential inflammatory marker linked to cardiovascular outcomes. This study aims investigate association NLR with all-cause and mortality among patients Methods analyzed data from 3067 hypertensive adults in National Health Nutritional Examination Surveys (NHANES) 2009 2014. Mortality details were obtained Death Index...
Abstract Exposure to atmospheric particulate matter PM 2.5 (aerodynamic diameter ≤ μm) has been epidemiologically associated with respiratory illnesses. However, recent data have suggested that is able infiltrate into circulation and elicit a systemic inflammatory response. Potential adverse effects of air pollutants the central nervous system ( CNS ) raised concerns, but whether causes neurotoxicity remains unclear. In this study, we demonstrated impairs tight junction endothelial cells...
Glucagon-like peptide-1 (GLP-1) may have direct favorable effects on cardiovascular system. The aim of this study was to investigate the GLP-1 analog exenatide improving coronary endothelial function in patients with type 2 diabetes and underlying mechanisms. newly diagnosed diabetic subjects were enrolled given either lifestyle intervention or plus treatment. After 12-wk treatment, flow velocity reserve (CFVR), an important indicator function, improved significantly, serum levels soluble...
Abstract Fragmentation reactions of protonated α-amino acids (AAs) were studied previously using tandem mass spectrometry (MS/MS) unit resolution. Isobaric fragmentation products and minor could have been overlooked or misannotated. In the present study, we examined patterns 19 AAs high-resolution electrospray ionization MS/MS (HR-ESI-MS/MS) with collision-induced dissociation (CID). from Met Trp resolved identified for first time. Previously unreported Met, Cys, Gln, Arg, Lys observed....
Circulating small extracellular vesicles (sEVs) and its associated proteins are of great interest in the early detection many diseases. However, there is no gold standard for plasma sEVs isolation, especially proteomic profiling which could be largely affected by contamination such as lipoproteins proteins. Previous studies suggested combinations different isolation methods improve yield purity isolated fractions. Nevertheless, systematic evaluation size-exclusion chromatography (SEC),...
BackgroundClinical trials and animal studies have shown that sodium-glucose co-transporter type 2 (SGLT2) inhibitors improve pancreatic beta cell function. Our study aimed to investigate the effect of dapagliflozin on islet morphology phenotype, explore origin possible reason regenerated cells.MethodsTwo diabetic mouse models, db/db mice alpha lineage-tracing (glucagon-β-gal) whose diabetes was induced by high fat diet combined with streptozotocin, were used. Mice treated daily intragastric...
Sodium–glucose cotransporter 2 inhibitors, efficacious antidiabetic agents that have cardiovascular and renal benefits, can promote pancreatic β-cell regeneration in type diabetic mice. However, the underlying mechanism remains unclear. In this study, we aimed to use multiomics identify mediators involved induced by dapagliflozin. We showed dapagliflozin lowered blood glucose level, upregulated plasma insulin increased islet area db/db Dapagliflozin reshaped gut microbiota modulated...
BackgroundGlucagon-like peptide-1 (GLP-1) and its based agents improve glycemic control. Although their attenuating effect on hepatic glucose output has drawn our attention for decades, the potential mechanisms remain unclear.MethodsCytokine array kit was used to assess cytokine profiles in db/db mice mouse primary hepatocytes treated with exenatide (exendin-4). Two diabetic models (db/db Pax6m/+) were a GLP-1 analog or liraglutide. The expression secretion of fibroblast growth factor 21...
The evolution of resistance to insecticides is well known be closely associated with the overexpression detoxifying enzymes. Although role glutathione S -transferase (GST) genes in insecticide has been widely reported, underlying regulatory mechanisms are poorly understood. Here, one GST gene ( GSTu1 ) and its antisense transcript (lnc- -AS) were identified cloned, both them upregulated several chlorantraniliprole-resistant Plutella xylostella populations. was confirmed involved...
Dysfunction of glucagon-secreting α-cells participates in the progression diabetes, and glucagon receptor (GCGR) antagonism is regarded as a novel strategy for diabetes therapy. GCGR upregulates glucagon-like peptide 1 (GLP-1) secretion and, notably, promotes β-cell regeneration diabetic mice. Here, we aimed to clarify role GLP-1 (GLP-1R) activated by and/or antagonism–induced regeneration. We showed that db/db mice type wild-type or Flox/cre mice, monoclonal antibody (mAb) improved glucose...
It has been reported that glucagon-like peptide-1 (GLP-1) agents are associated with an increased risk of pancreatic cancer in patients type 2 diabetes. Reports have indicated GLP-1 promotes metaplasia and premalignant lesions. The aims this study were to determine the effects GLP-1-based therapy on cells.Immunohistochemistry was used investigate receptor (GLP-1R) expression 30 human tissues. We also analysed clinicopathological data each patient's prognosis. Two cell lines evaluate vitro...
Glucagon-like peptide-1 (GLP-1) promotes pancreatic β-cell regeneration through GLP-1 receptor (GLP-1R) activation. However, whether it exocrine pancreas growth and thereby increases the risk of cancer has been a topic debate in recent years. Clinical data animal studies published so far have controversial. In present study, we report that GLP-1R activation with liraglutide inhibited promoted apoptosis human cell lines vitro attenuated tumor mouse xenograft model vivo. These effects were...
The aim of this study was to investigate whether and how metformin ameliorated endothelial dysfunction induced by fluctuating glucose (FG) in human umbilical vein cells (HUVECs).HUVECs, which were exposed FG induce dysfunction, incubated with nitric oxide synthase (NOS) inhibitor N-nitro-l-arginine-methyl ester (l-NAME), nicotinamide adenine dinucleotide phosphate (NADPH) oxidase apocynin, and/or adenosine monophosphate-activated protein kinase (AMPK) compound C. oxidative stress NOS (eNOS)...