A5100772707- Pancreatic function and diabetes
- Diabetes Treatment and Management
- Diabetes Management and Research
- Gastric Cancer Management and Outcomes
- Esophageal and GI Pathology
- Biliary and Gastrointestinal Fistulas
- Pain Mechanisms and Treatments
- Metabolism, Diabetes, and Cancer
- Gastrointestinal disorders and treatments
- Metastasis and carcinoma case studies
- Corneal surgery and disorders
- Hormonal Regulation and Hypertension
- Pituitary Gland Disorders and Treatments
- S100 Proteins and Annexins
- Gastrointestinal Tumor Research and Treatment
- Alzheimer's disease research and treatments
- Cancer-related molecular mechanisms research
- Diverticular Disease and Complications
- FOXO transcription factor regulation
- Intraocular Surgery and Lenses
- Circadian rhythm and melatonin
- Ion channel regulation and function
- Diabetes and associated disorders
- Minimally Invasive Surgical Techniques
- Antiplatelet Therapy and Cardiovascular Diseases
Lanzhou University
2022-2024
Peking University Third Hospital
2020-2023
Peking University
2020-2023
Central South University
2018-2022
Xiangya Hospital Central South University
2018
Capital Medical University
2009-2015
Beijing Friendship Hospital
2011-2015
Wenzhou Medical University
2015
Dysfunction of glucagon-secreting α-cells participates in the progression diabetes, and glucagon receptor (GCGR) antagonism is regarded as a novel strategy for diabetes therapy. GCGR upregulates glucagon-like peptide 1 (GLP-1) secretion and, notably, promotes β-cell regeneration diabetic mice. Here, we aimed to clarify role GLP-1 (GLP-1R) activated by and/or antagonism–induced regeneration. We showed that db/db mice type wild-type or Flox/cre mice, monoclonal antibody (mAb) improved glucose...
G protein–coupled receptor 39 (GPR39) senses the change of extracellular divalent zinc ion and signals through multiple proteins to a broad spectrum downstream effectors. Here, we found that GPR39 was prevalent at inhibitory synapses spinal cord somatostatin-positive (SOM + ) interneurons, mechanosensitive subpopulation is critical for conveyance mechanical pain. complexed specifically with glycine receptors (GlyRs) helped maintain glycinergic transmission in manner independent protein...
Abstract High myopia is one of the leading causes visual impairment worldwide with high heritability. We have previously identified genetic contribution SLC39A5 to nonsyndromic and demonstrated that disease‐related mutations dysregulate TGF‐β pathway. In this study, mechanisms underlying involvement in pathogenesis are determined. observed morphogenesis migration abnormalities knockout (KO) human embryonic kidney cells (HEK293) found a significant injury ECM constituents. RNA‐seq qRT‐PCR...
To investigate the effects of long-term administration tacrolimus (also known as FK506) on pain-related behaviors in mice and to study underlying mechanism pain induced by FK506 via measuring effect synaptic expression phosphorylation alpha-amino-3-hyroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor spinal cord dorsal horn mice.
Glucagon-secreting pancreatic α-cells can interact with β-cells. However, the long-term effect of glucagon on function and phenotype β-cells has remained elusive. Our new finding shows that induces β-cell dedifferentiation in cultured FoxO1 inhibitor mimicks whereas signaling blockage by GCGR mAb reverses glucagon. In type 2 diabetic mice, increases area, improves function, inhibits dedifferentiation, is partially mediated FoxO1.
Sodium-glucose co-transporter 2 inhibitors, including dapagliflozin, improve ß cell function in type diabetic individuals. Whether dapagliflozin can protect islet microvascular endothelial cells (IMECs) and thus contribute to the improvement of remains unknown.The db/db mice were treated with or vehicle for 6 weeks. function, capillaries levels inflammatory chemokines IMECs detected. The mouse IMEC line MS-1 incubated palmitate and/or 24 h. Angiogenesis chemokine evaluated, involved...
Although large-scale neuroimaging studies have demonstrated similar patterns of structural brain abnormalities across major psychiatric disorders, the underlying genetic etiology behind these cross-disorder is not well understood.We quantified extent shared components between cortical structures and disorders (CS-MPD) by using genome-wide association study (GWAS) summary statistics 70 (surface area thickness whole cortex 34 regions) five consisting attention deficit hyperactivity disorder...
<p>Dysfunction of glucagon-secreting α-cells participates in the progression diabetes, and glucagon receptor (GCGR) antagonism is regarded as a novel strategy for diabetes therapy. GCGR upregulates glucagon-like peptide-1 (GLP-1) secretion, notably promotes β-cell regeneration diabetic mice. Here, we aimed to clarify role GLP-1 (GLP-1R) activated by and/or antagonism-induced regeneration. We showed that <em>db/db</em> mice type 1 wild-type or Flox/cre mice, monoclonal...
Objective To explore the diagnosis and treatment of tumor associated gastrocolic fistula (GCF).Methods The records 4 patients with GCF between August 2008 to February 2014 were retrospectively analyzed.Three female one male patients,those whose average age 61 years,have been pathologically diagnosed postoperatively as caused by malignant diseases.The main clinical symptoms diarrhea (3 cases),fecal vomitus cases),weight loss (4 cases),and abdominal pain cases).Positive diagnostic tests for...
Background. Transumbilical single-incision laparoscopic surgery (TUSILS) has emerged as an advanced technique for minimally invasive surgery. Recently, the authors performed TUSIL resection of ileocecal junction benign lesions. Methods. The report surgical and clinical effect in 2 patients. Results. operations were completely successful with satisfactory scarless recovery. No postoperative complications occurred. Conclusions. was feasible safe patients might lead to expansion indications TUSILS.
Objective Through the prospective comparative study of laparoscopic-assistcd and open radical gastrectomy for gastric cancer,to evaluate safety,feasibility,radical postoperative short-term efficacy laparoscopic-assisted gastrectomy.Methods From May 2010 to December 2011,29 cancer patients matching inclusion criteria were chosen as laparoscopic group.According same criteria,29 with or similar clinical T stage (AJCC 7th edition) extracted group.Then two groups information was carried out a...
Objective This study aimed to establish a prediction system of lymph node metastasis gastric cancer patients,to facilitate guiding the treatment patients with cancer.Method s We analyzed 255 cases from January 2005 December 2009 in Beijing Friendship Hospital.They all had surgery or palliative gastrectomy and then examined pathological metastasis.Their gender,age,preoperative weight loss,anemia,pyloric obstruction,chronic disease history,family history,tumor location,tumor size,higher...
<p>Dysfunction of glucagon-secreting α-cells participates in the progression diabetes, and glucagon receptor (GCGR) antagonism is regarded as a novel strategy for diabetes therapy. GCGR upregulates glucagon-like peptide-1 (GLP-1) secretion, notably promotes β-cell regeneration diabetic mice. Here, we aimed to clarify role GLP-1 (GLP-1R) activated by and/or antagonism-induced regeneration. We showed that <em>db/db</em> mice type 1 wild-type or Flox/cre mice, monoclonal...
<p>Dysfunction of glucagon-secreting α-cells participates in the progression diabetes, and glucagon receptor (GCGR) antagonism is regarded as a novel strategy for diabetes therapy. GCGR upregulates glucagon-like peptide-1 (GLP-1) secretion, notably promotes β-cell regeneration diabetic mice. Here, we aimed to clarify role GLP-1 (GLP-1R) activated by and/or antagonism-induced regeneration. We showed that <em>db/db</em> mice type 1 wild-type or Flox/cre mice, monoclonal...