A5060065120- Pain Mechanisms and Treatments
- Neuroscience and Neuropharmacology Research
- Ion channel regulation and function
- Neuropeptides and Animal Physiology
- Cytokine Signaling Pathways and Interactions
- Reproductive Biology and Fertility
- Sperm and Testicular Function
- Neurobiology and Insect Physiology Research
- Reproductive Health and Technologies
- RNA modifications and cancer
- Supercapacitor Materials and Fabrication
- Cancer-related molecular mechanisms research
- Autophagy in Disease and Therapy
- Receptor Mechanisms and Signaling
- Atrial Fibrillation Management and Outcomes
- Ferroptosis and cancer prognosis
- NF-κB Signaling Pathways
- Cardiac Imaging and Diagnostics
- Ovarian function and disorders
- Vitamin D Research Studies
- Radiomics and Machine Learning in Medical Imaging
- Protein Tyrosine Phosphatases
- Liver Disease Diagnosis and Treatment
- Advancements in Battery Materials
- Exercise and Physiological Responses
First Affiliated Hospital of Jinan University
2024-2025
Lanzhou University
2011-2024
Nanjing Drum Tower Hospital
2019-2024
Chongqing University
2024
Suizhou Central Hospital
2024
China Medical University
2024
Nanjing Medical University
2024
Chongqing Normal University
2021-2023
Key Laboratory of Guangdong Province
2023
State Key Laboratory of Oncology in South China
2023
// Zhen Wei Zou 1 , Charlie Ma 2 Lorraine Medoro Lili Chen Bin Wang Roohi Gupta Ting Liu 3 Xian Zi Yang 4 Tian Ruo 5 Wen Jie Zhang 6 Pin Dong Li Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China Department Radiation Oncology, Fox Chase American Oncologic Pennsylvania, PA 19111, USA Institute Infection Immunology, Sun Yat-sen State Key Laboratory Oncology in Southern China, Collaborative Innovation Center for Medicine,...
We focused on the KCNQ1OT1/miR-15a/PD-L1 axis and explored its significance in regulating immune evasion malignant behaviors of prostate cancer (PC) cells.The expression levels KCNQ1OT1, miR-15a, PD-L1, CD8 cells or tissues were examined by RT-qPCR, western blot immunohistochemistry (IHC) assays. The direct regulations between miR-15a PD-L1 validated luciferase reporter assay. PC co-cultured with CD8+ T to study evasion. Proliferation, apoptosis, migration invasion abilities detected MTT,...
Selective inhibition of GluN2B-containing NMDA receptor (GluN2BR) in spinal dorsal horn effectively alleviates inflammatory pain, suggesting the up-regulation GluN2BR function involved central sensitization. Previous studies have demonstrated that increase synaptic expression serves as a key step to enhance after intradermal injection Complete Freund's Adjuvant (CFA). Here, we showed cAMP-dependent protein kinase (PKA) played an important role redistributing at synapses, because PKA activity...
Abstract Artificial intelligence can potentially provide a substantial role in streamlining chest computed tomography (CT) diagnosis of COVID-19 patients. However, several critical hurdles have impeded the development robust AI model, which include deficiency, isolation, and heterogeneity CT data generated from diverse institutions. These bring about lack generalization model therefore prevent it applications clinical practices. To overcome this, we proposed federated learning-based Unified...
Diabetic cardiomyopathy (DCM) is a serious complication in patients with type 2 diabetes mellitus, and its mechanisms are complex poorly understood. Despite growing evidence suggesting that ferroptosis plays significant role cardiovascular disease, it has been less extensively studied DCM. Fibroblast growth factor 21 (FGF21), whose mechanism of action closely related to ferroptosis, widely utilized studies focused on the prevention treatment glucolipid metabolism-related diseases diseases....
The association between body roundness index (BRI) and all-cause mortality the occurrence of cardiovascular disease (CVD) in patients with diabetes is unknown. This study aimed to determine BRI all-cause/CVD a diabetic cohort. A total 8227 individuals from 1999-2018 National Health Nutrition Examination Survey (NHANES) database were included. Multifactorial Cox regression models used analyze diabetes. Multivariate-adjusted restricted cubic spline (RCS) was test for nonlinearity. During...
Filamentous actin binding protein neurabin I (NrbI) targets phosphatase-1 (PP1) to specific postsynaptic microdomains, exerting critical control over AMPA receptor (AMPAR)-mediated synaptic transmission. NrbI-targeted PP1, which promotes depression upon long-term (LTD) stimuli, serves prevent under basal conditions. The present studies investigate this opposite regulation of AMPAR trafficking during transmission and LTD by expressing NrbI or mutant, is defective in PP1 binding, hippocampal...
Considerable evidence has indicated that the aberrant, sustained enhancement of spinal NMDA receptors (NMDARs) function is closely associated with behavioral sensitization during inflammatory pain. However, molecular mechanisms underlying inflammation-induced NMDARs hyperfunction remain poorly understood. The present study performed immunoblotting analysis to evaluate possible changes in protein expression after injection complete Freund's adjuvant (CFA) mice. We found CFA did not affect...
Abstract Calcium influx via N‐methyl‐D‐aspartate (NMDA)‐subtype glutamate receptors (NMDARs) regulates the intracellular trafficking of NMDARs, leading to long‐lasting modification NMDAR‐mediated synaptic transmission that is involved in development, learning, and plasticity. The present study investigated contribution such NMDAR‐dependent spinal dorsal horn induction pain hypersensitivity. Our data showed direct activation NMDARs by intrathecal NMDA application elicited pronounced...
Tight junctions (TJs) are the most important structure of blood–brain barrier (BBB). Studies have shown that triggering white matter lesions (WMLs) may be related to a BBB dysfunction, but rarely studies observed progressive changes in TJs longitudinally. In our present study, ultrastructure was using transmission electron microscope Stroke-prone Renalvascular Hypertensive Rats. Western blotting used detect TJ-related proteins zonula occludens-1 and occludin. The results showed Rats,...
Protein phosphatase-1 (PP1), anchored by regulatory or targeting proteins at excitatory glutamatergic synapses, controls the phosphorylation of postsynaptic substrates and regulates neurotransmission plasticity. Here, we found that spinophilin, an actin-binding protein targets PP1 density, served as a scaffold for extracellular signal-regulated kinase (ERK) signaling components. Through C-terminal PDZ domain, spinophilin directly interacted with ERK its upstream mitogen-activated (MEK). PP1,...
Mitochondrial ribosomal protein S23 (MRPS23), a component of the ribosome small subunit, has been reported to be overexpressed in various cancers and predicted involved increased cell proliferation. It confirmed that MRPS23 was regulation breast cancer hepatocellular carcinoma However, little is known about function glioma. In this study, we found expression higher gliomas than adjacent normal tissues. Higher correlated with poorer prognosis, unfavorable histological features, absence...
G protein–coupled receptor 39 (GPR39) senses the change of extracellular divalent zinc ion and signals through multiple proteins to a broad spectrum downstream effectors. Here, we found that GPR39 was prevalent at inhibitory synapses spinal cord somatostatin-positive (SOM + ) interneurons, mechanosensitive subpopulation is critical for conveyance mechanical pain. complexed specifically with glycine receptors (GlyRs) helped maintain glycinergic transmission in manner independent protein...
Purpose: To explore the relationship between Red cell distribution width/albumin ratio (RAR) and vascular complications, including atherosclerosis of lower limbs, diabetic nephropathy(DN), retinopathy(DR), in patients with type 2 diabetes mellitus (T2DM). Patients Methods:The study included 427 who were hospitalized Department Endocrinology First Affiliated Hospital Jinan University (Guangzhou, China) April 1, 2022 May 31, 2023.Baseline characteristics displayed according to quartiles...
Background: Reactive oxygen species (ROS) act as signal mediators to induce tumorigenesis. Objective: This study aims explore whether chemokine CXCL14 is involved in the proliferation and migration of ROS-induced colorectal cancer (CRC) cells. Methods: The proliferative migratory capacities CRC cells treated with or without H2O2 were measured by various methods, including CKK-8 assay, colony formation flow cytometry, wounding healing assay. Results: results revealed that promoted regulating...