A5101976638- Muscle Physiology and Disorders
- Cancer, Lipids, and Metabolism
- Electromagnetic Fields and Biological Effects
- Mechanisms of cancer metastasis
- Cancer-related gene regulation
- Cancer, Hypoxia, and Metabolism
- RNA modifications and cancer
- MicroRNA in disease regulation
- Nutrition and Health in Aging
- Natural product bioactivities and synthesis
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- Angiogenesis and VEGF in Cancer
- Ubiquitin and proteasome pathways
- Protease and Inhibitor Mechanisms
- Fibroblast Growth Factor Research
- Amino Acid Enzymes and Metabolism
- Circular RNAs in diseases
- Ion channel regulation and function
- Magnesium in Health and Disease
- RNA Research and Splicing
- Proteoglycans and glycosaminoglycans research
- Mesenchymal stem cell research
- Medicinal Plant Pharmacodynamics Research
- Esophageal Cancer Research and Treatment
Suizhou Central Hospital
2009-2024
Shaanxi University of Chinese Medicine
2023
Wenzhou Medical University
2022
First Affiliated Hospital of Wenzhou Medical University
2022
Jiujiang First People's Hospital
2022
Jiangsu University
2020
Xuzhou Cancer Hospital
2020
Charité - Universitätsmedizin Berlin
2020
Liaocheng People's Hospital
2019
Cedars-Sinai Medical Center
2019
Aim and Background: Cervical cancer remains the third most common in women globally after breast colorectal cancer. Well-characterized biomarkers are necessary for early diagnosis to predict metastatic progression effective therapy. MiRNAs can regulate gene expression, cell growth, differentiation apoptosis by targeting mRNAs translational repression or degradation tumor cells. The present study was conducted assess expression of miR93, miR200a, RECK, MMP2, MMP9 invasive cervical carcinoma,...
EFEMP1, a kind of extracellular matrix (ECM) protein, has been suggested to correlate with the development different types carcinoma. However, its functions in ovarian cancer remain unclear. In our study, we performed cDNA microarray analysis and identified EFEMP1 dramatically elevated highly invasive subclone, compared low subclone. Lentivirus transfection experiments were constructed afterwards. The results demonstrated that knockdown significantly inhibited cell proliferation induced...
Mitochondrial ribosomal protein S23 (MRPS23), a component of the ribosome small subunit, has been reported to be overexpressed in various cancers and predicted involved increased cell proliferation. It confirmed that MRPS23 was regulation breast cancer hepatocellular carcinoma However, little is known about function glioma. In this study, we found expression higher gliomas than adjacent normal tissues. Higher correlated with poorer prognosis, unfavorable histological features, absence...
Abstract The aim of this study was to estimate whether methotrexate (MTX) promotes cognitive impairment via increased ER stress and disrupted H 2 S signaling in the hippocampus may alleviate MTX‐induced by inhibiting through CHOP caspase‐12. Cognitive behaviors were observed Morris water maze test, apoptosis neurons assessed TUNEL assay. production analyzed DCX Ki67 immunohistochemistry. expressions caspase‐12 determined Western blot MTX expression number TUNEL‐positive cells endogenous...
We first reported that electroacupuncture (EA) pretreatment at the Baihui acupoint (GV20) induces ischemic tolerance. Our recent study demonstrated N-Myc downstream-regulated gene 2 (NDRG2) expression was up-regulated following transient focal cerebral ischemia. Therefore, we investigated whether NDRG2 involved in tolerance induced by EA rats.Twenty-four hours after end of last pretreatment, ischemia middle artery occlusion (MCAO) for 120 minutes male Sprague-Dawley rats. The neurobehavioral...
Cancer cachexia is often present in patients with advanced malignant tumors, and the subsequent body weight reduction results poor quality of life. However, there has been no progress developing effective clinical therapeutic strategies for skeletal muscle wasting cancer cachexia. Herein, we explored functions pantoprazole on wasting.The mouse colon adenocarcinoma cell line C26 was inoculated right forelimb male BALB/C mice to establish a model. The animals were treated or without different...
Hepatocellular carcinoma (HCC) is one of the most common and lethal cancer types worldwide. Recent studies found Coiled-coil domain-containing protein 50 (CCDC50) could regulate nuclear factor kappa-B p53 signalling pathways in cancer. Nevertheless, underlying biological function potential mechanisms CCDC50 driving progression HCC remain unclear. In this study, we that was up-regulated HCC, its higher expression associated with adverse clinical outcomes poor characteristics. The results Cox...
Ilex kudingcha C.J. Tseng (kudingcha) is a traditional Chinese beverage widely consumed in East Asia. In the present study, preventative effect of on gastric injury was determined Sprague‑Dawley (SD) rats. High concentrations were observed to reduce levels serum proinflammatory cytokines, interleukin 6 (IL-6) and tumor necrosis factor‑α (TNF‑α), compared with low kudingcha. Gastric secretion volumes highest control rats reduced following order; 250, 500 1,000 mg/kg kudingcha‑treated normal...
Cardiovascular diseases are very harmful to human life and health. Reperfusion therapy is a standard method treat cardiovascular has achieved high clinical effects. However, this treatment likely cause myocardial ischemia-reperfusion injury. It been reported that the Rho kinase inhibitor fasudil can interfere with cardiomyocyte apoptosis through Rho-ROCK signaling pathway, so it often used diseases. The essay aims research specific influence of on cardiac damage in mouses signal path its...
Ubiquitin-proteasome pathway (UPP) is the major system for selective degradation of cellular proteins that play key roles in processes. Previous study indicated ubiquitin-proteasome inhibitor MG-132 could inhibit growth some carcinoma. However, anti-carcinoma mechanism unclear. Our objective was to investigate mechanisms inhibitory effect on gastric carcinoma cells. Gastric cell SGC-7901 treated with MG-132. Cell suppression evaluated 3-(4,5-dimethylthiazole-2-yl)-2,5-diphenyl tetrazolium...
BACKGROUND:To observe the effect of QiShenYiQi pill (QSYQ) on experimental autoimmune myocarditis rats, and to explore its mechanism action. MATERIAL AND METHODS:Lewis rats underwent injection myocardial myosin mixed with Freund's complete adjuvant were randomized into 3 groups: model, valsartan, QSYQ groups. Rats injected phosphate-buffered saline (PBS) used as control group. euthanized at 4 8 weeks, we weighed rat body mass, heart left ventricular mass. Myocardium sections stained...
The abnormal expression of cadherin-11 (CDH11) affects the progression several types cancer. However, pattern and prognostic value CDH11 in gastric cancer (GC) have not been reported. In present study, patients with GC its effect on their survival were analyzed using public databases. tissues was significantly higher compared that normal tissues. advanced early GC, increased associated tumor poor prognosis GC. high level methylation promoter sufficient to reverse upregulation caused by...