A5100411585- Connective Tissue Growth Factor Research
- Cardiac Fibrosis and Remodeling
- Lipid metabolism and disorders
- Birth, Development, and Health
- Functional Brain Connectivity Studies
- Glaucoma and retinal disorders
- Protease and Inhibitor Mechanisms
- Advanced Neuroimaging Techniques and Applications
- Traditional Chinese Medicine Analysis
- Ion channel regulation and function
- Traditional and Medicinal Uses of Annonaceae
- Retinal Imaging and Analysis
- Bone health and osteoporosis research
- Cardiac Imaging and Diagnostics
- Cardiac electrophysiology and arrhythmias
- Bone health and treatments
- Apelin-related biomedical research
- Adipokines, Inflammation, and Metabolic Diseases
- Pancreatic function and diabetes
- Cardiovascular Disease and Adiposity
- Diabetes and associated disorders
- Alkaloids: synthesis and pharmacology
- Kruppel-like factors research
- Natural product bioactivities and synthesis
- Retinal Diseases and Treatments
Shandong First Medical University
2021-2025
Beijing Luhe Hospital Affiliated to Capital Medical University
2024
Xinjiang Normal University
2024
North China University of Science and Technology
2023
Peking Union Medical College Hospital
2017-2022
Chinese Academy of Medical Sciences & Peking Union Medical College
2017-2022
Beijing Tsinghua Chang Gung Hospital
2022
Beijing University of Civil Engineering and Architecture
2022
Tsinghua University
2022
Anhui Mental Health Center
2021
Emerging evidence supports a key role for the gut microbiota in metabolic diseases, including type 2 diabetes (T2D) and obesity. The dipeptidyl peptidase-4 inhibitor vildagliptin is highly efficacious treating T2D. However, whether can alter microbiome still unclear. This study aimed to identify modifies structure during T2D treatment. Diabetic Sprague-Dawley (SD) rats were induced by high-fat diet streptozotocin injection (HFD/STZ). orally administered low dose of (LV, 0.01 g/kg/d...
AimsRenalase, an enzyme that can metabolize catecholamine, was recently reported to attenuate the ischaemia/reperfusion (I/R)-induced cardiac injury. This work undertaken investigate functions and regulation mechanisms of renalase in protection against I/R
There is increasing evidence that Alzheimer's disease (AD) patients may present decreased cerebral blood perfusion before pathological brain changes. Using the retina as a window to brain, we can study disorders of central nervous system through eyes.This aimed investigate differences in retinal structure and vessel density (VD) between with mild AD healthy controls (HCs). Furthermore, explored relationship VD cognitive function.We enrolled 37 29 age-matched HCs who underwent standard...
Accumulating evidence suggests that oxidative stress is associated with osteoporosis. Serum uric acid (UA) a strong endogenous antioxidant. Therefore, we investigated the relationship between serum UA and BMD in Chinese men T2DM. In this cross-sectional study of 621 T2DM, BMDs at lumbar spine (L2–4), femoral neck (FN), total hip (TH) were measured by dual-energy X-ray absorptiometry (DXA). levels UA, calcium (Ca), 25-OH vitamin D3 (vitD3), parathyroid hormone (PTH), creatinine (Cr) also...
Increasing evidence shows that diabetes causes cardiac dysfunction. We hypothesized a glucagon-like peptide-1 (GLP-1) analog, liraglutide, would attenuate dysfunction in diabetic rats. A total of 24 Sprague–Dawley (SD) rats were divided into two groups fed either normal diet (normal, n=6) or high-fat (HFD, n=18) for 4 weeks. Then, the HFD injected with streptozotocin (STZ) to create rat model. Diabetic three subgroups receiving vehicle (diabetic, n=6), low dose liraglutide (Llirag, 0.2...
BACKGROUND:This study investigated the mechanism of miR-145 in targeting connective tissue growth factor (CTGF), which affects proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT) ESCC cells. MATERIAL AND METHODS:A total 50 tissues their corresponding normal adjacent esophageal samples were collected. Then, expression both clinical specimens cell lines was detected using quantitative real-time PCR. CTGF protein immunohistochemistry. Dual luciferase reporter gene...
Scope: Diabetic retinopathy (DR) is a severe microvascular complication of diabetes. Previous clinical trials have shown that Compound Danshen Dripping Pill (CDDP) improves DR symptoms. However, the mechanism involved remains unclear. Procedures: Rats fed high-fat diet and injected with streptozotocin (STZ) were used as an experimental type 2 diabetes rodent model. CDDP was administered to two groups diabetic rats at 0.2 0.4 g/kg/day via gastric gavage for 12 weeks. After weeks treatment,...
Abstract Background: Skeletal muscle adipose tissue (AT) infiltration, or myosteatosis, appears to be greater in African compared with European ancestry individuals and may play a role type 2 diabetes mellitus (T2DM), disease that disproportionally affects populations. Inflammation is one mechanism link myosteatosis increased T2DM risk, but studies examining the relationship between inflammation are lacking.To examine these associations, we measured skeletal subcutaneous AT, intermuscular...
What is the central question of this study? are effects protein kinase C (PKC) and Ca(2+) -calmodulin-dependent II (CaMKII) on late sodium current (INaL ), reverse Na(+) -Ca(2+) exchange (reverse INCX ) or intracellular levels changed by ouabain? main finding its importance? Ouabain, even at low concentrations (0.5-8.0 μm), can increase INaL , these may contribute to effect glycoside transients contractility. Both PKC CaMKII activities mediate modulate processes. It has been reported that...
Abstract The purpose of this study was to better understand whether interleukin-13 (IL-13) and connective tissue growth factor (CTGF) are highly expressed during foreign body encapsulation subcutaneous devices. Mock biosensors were implanted into rats for three lengths time (7–, 21– 48–55 days) address different stages the response. Using quantitative real-time PCR immunofluorescence, expression IL13, CTGF, collagen 1, decorin fibronectin measured in tissue. IL-13, a product Th2 cells, at...
This study investigated the effect of QiShenYiQi pill (QSYQ) on myocardial collagen metabolism in rats with partial abdominal aortic coarctation and explored its mechanism action. A series assays were used to detect QSYQ systolic blood pressure, heart mass index, left ventricle HYP, expression PICP, PIIINT, CTX-I serum, MMP-1, TIMP-1 myocardium. We observed that can reduce rate synthesis increase degradation. It also effectively improved degree fibrosis it had a tendency have greater longer...
BACKGROUND:To observe the effect of QiShenYiQi pill (QSYQ) on experimental autoimmune myocarditis rats, and to explore its mechanism action. MATERIAL AND METHODS:Lewis rats underwent injection myocardial myosin mixed with Freund's complete adjuvant were randomized into 3 groups: model, valsartan, QSYQ groups. Rats injected phosphate-buffered saline (PBS) used as control group. euthanized at 4 8 weeks, we weighed rat body mass, heart left ventricular mass. Myocardium sections stained...
BACKGROUND Long noncoding RNAs play important roles in the development of various diseases. This study aimed to evaluate effects and mechanism VIM antisense RNA 1 (VIM-AS1) preeclampsia. MATERIAL AND METHODS HTR-8/SVneo cells were divided into normal control (NC), Model, Blank, VIM-AS1 groups. These groups analyzed for their gene expressions by RT-PCR, cell invasion was assessed transwell migration wound healing, morphology microscopy examination, E-cadherin, Snail, Vimentin genes RT-PCR WB...
Abstract Background Type 2 diabetes mellitus (T2DM) is associated with a higher fracture risk. Sex hormones are important for maintaining skeletal health. It not clear which sex hormone(s) contribute(s) to bone mineral density (BMD) and risk in males T2DM. This study investigated the relationships of these parameters Methods involved 482 men BMDs at lumbar spine (L2‐4), femoral neck (FN), total hip (TH) were measured by dual‐energy X‐ray absorptiometry (DXA). The 10‐year probability...
White matter hyperintensities (WMHs) on magnetic resonance imaging (MRI) is frequently presumed to be secondary cerebral small vessel disease (CSVD) and associated with cognitive decline. The cerebellum plays a key role in cognition has dense connections other brain regions. Thus, the aim of this study was investigate if cerebellar abnormalities could occur CSVD patients WMHs possible association performances.A total 104 right-handed were divided into mild group (n = 39), moderate 37),...
Urothelial bladder cancer (UBC) is the most common urinary neoplasm in China. CCN family protein 2 (CCN2), a cysteine-rich matricellular protein, abnormally expressed several types and involved tumor progression or chemo-resistance. However, detailed expression patterns effects of CCN2 UBC still remain unknown. We found that down-regulation suppressed proliferation, migration invasion cells vitro targeting decelerated xenograft growth vivo. When treated with mitomycin C (MMC),...