A5101706931- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- Circular RNAs in diseases
- Genomics and Chromatin Dynamics
- MicroRNA in disease regulation
- Advanced Glycation End Products research
- Biological Activity of Diterpenoids and Biflavonoids
- Trauma Management and Diagnosis
- Cardiac Ischemia and Reperfusion
- Connective Tissue Growth Factor Research
- Dermatological and Skeletal Disorders
- DNA Repair Mechanisms
- Genetic Syndromes and Imprinting
- Parathyroid Disorders and Treatments
- Identification and Quantification in Food
- Ophthalmology and Eye Disorders
- Thyroid Cancer Diagnosis and Treatment
- Advanced Battery Technologies Research
- Congenital Diaphragmatic Hernia Studies
- Ferroptosis and cancer prognosis
- Autoimmune and Inflammatory Disorders Research
- Glioma Diagnosis and Treatment
- Bacteriophages and microbial interactions
Sun Yat-sen University
2016-2022
Fifth Affiliated Hospital of Sun Yat-sen University
2016-2022
Nanjing Drum Tower Hospital
2020
Sun Yat-sen University Cancer Center
2017-2019
State Key Laboratory of Oncology in South China
2018
Center for Rheumatology
2017
Institute of Soil Science
2014
Hong Kong Baptist University
2014
Chinese Academy of Sciences
2014
Chenzhou First People's Hospital
2008
HP1γ, encoded by CBX3, is associated with cancer progression and patient prognosis. However, the prognostic value functions of CBX3/HP1γ in hepatocellular carcinoma (HCC) remain unclear. Here, we performed a bioinformatics analysis using Oncomine, TCGA Human Protein Atlas databases, Kaplan-Meier plotter, UALCAN web-portal to explore expression significance patients different cancers, including liver cancer. HCC tissues microarrays containing 354 samples were examined immunohistochemical...
BACKGROUND Tongue squamous cell carcinoma (TSCC) is a major type of oral cancers and has remained an intractable cancer over the past decades. The aim this study was to identify differentially expressed genes (DEGs) during TSCC reveal their potential mechanisms. MATERIAL AND METHODS gene expression profiles GSE13601 were downloaded from GEO database. dataset contains 57 samples, including 31 tongue SCC samples 26 matched normal mucosa samples. Gene ontology (GO) Kyoto Encyclopedia Genes...
Bladder cancer (BC) is one of the most prevalent malignancies genitourinary system, yet underlying mechanism BC progression still remains unclear. Growth arrest and DNA damage-inducible 45 alpha (GADD45a) a repressive gene implicated in cell cycle regulation, as well human cancers development. However, its role to be determined.First, quantitative real-time polymerase chain reaction (PCR) Western blot assays were used detect GADD45a expression tissues adjacent non-tumor tissues, bladder...
Abstract Thyroid cancer is commonly seen in the clinic with a rapidly increasing incidence globally. COX-2 overexpression correlates pathologic type of thyroid carcinoma, and it has been suggested that associated poor prognosis. However, little known about its upstream regulatory mechanism. Bioinformatics transcription factor AP-2 beta (TFAP2B) might specifically bind to promoter, which was confirmed by biotin-labeled promoter pulldown luciferase reporter assays. We performed western blot...
Xenotropic and polytropic retrovirus receptor 1 (XPR1), a previously identified cellular for several murine leukemia viruses, plays role in many pathophysiological processes. However, the of XPR1 human cancers has not yet been characterized.Real-time PCR western blotting assay were used to measure expression tongue squamous cell carcinoma (TSCC) tissues. Expression p65 clinical specimens was analyzed using immunohistochemical assay. The function on progression TSCC explored vitro vivo...
BACKGROUND:This study investigated the mechanism of miR-145 in targeting connective tissue growth factor (CTGF), which affects proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT) ESCC cells. MATERIAL AND METHODS:A total 50 tissues their corresponding normal adjacent esophageal samples were collected. Then, expression both clinical specimens cell lines was detected using quantitative real-time PCR. CTGF protein immunohistochemistry. Dual luciferase reporter gene...
The aim of this study was to assess sensitivity and responsiveness power Doppler ultrasound (PDUS) in detecting enthesitis for ankylosing spondylitis (AS) patients compared clinical examinations. Twenty AS initiating etanerceptunderwent PDUS examinations six bilateral entheseal sites at baseline after 1, 2 3 months treatment. Clinical identified least one lesion nine (45%) 19 (95%) patients, respectively. Furthermore, 240 examined these 20 detected 123 lesions (51.3% sites), with only 47...
Clinically, we have observed that some oral cancer patients a history of radiotherapy for head and neck cancer; named this condition radiotherapy-associated (RAC). Gingival cancer, which is usually juxtaposed with other subtypes, seldom reported individually, there are few reports on the association between incidence radiation therapy. Therefore, study aimed to elucidate clinicopathological features prognosis second primary gingival squamous cell carcinoma after radiotherapy. The data...
The ~80 amino acid A box DNA-binding domain of high mobility group 1 (HMGB1) protein antagonizes proinflammatory responses during myocardial ischemia reperfusion (I/R) injury. exact role microRNA-21 (miR-21) is unknown, but its altered levels are evident in I/R This study examined the roles HMGB1 A-box and miR-21 rat injury model. Sixty Sprague-Dawley rats were randomly divided into six equal groups: (1) Sham; (2) I/R; (3) Ischemic postconditioning (IPost); (4) AntagomiR-21 post-treatment;...
Increased expression of CBX3/HP1γ, a core component heterochromatin protein 1, has recently proved to be involved in human tumorigenesis and patient prognosis. The present study aimed investigate the CBX3/HP1γ its clinicopathological significance primary tongue squamous cell carcinoma (TSCC). Gene profiles TSCC from Oncomine database were analyzed. at level was measured using immunohistochemistry (IHC). potential associations between multiple parameters estimated Chi square test. In...
Long noncoding RNAs (lncRNAs) are emerging as critical regulators of gene expression in the immune system, but their impact on neuropsychiatric systemic lupus erythematosus (NPSLE) remains unknown.RNA sequencing analysis was used to screen comprehensive profile lncRNAs and messenger (mRNAs) peripheral blood mononuclear cells (PBMCs) from NPSLE patients, active SLE patients who had never experienced manifestations (Non-NPSLE) healthy controls. Differentially expressed (DE) lncRNA levels were...
Esophageal cancer (EC) is a highly malignant gastrointestinal tumor, and esophageal squamous cell carcinoma (ESCC) one of the most common histological types EC. MicroRNAs (miRNAs) are small noncoding RNAs closely related to tumorigenesis tumor progression. In addition, Nestin an intermediate filament protein (class VI) contributes progression numerous tumors. However, correlation between miRNAs in ESCC remains unclear. This study aimed investigate relationship miR-204-5p ESCC. First,...
A Gram-staining-positive, endospore-forming, moderately alkaliphilic bacterium, strain NPK15 T , was isolated from a typical sandy loam soil under long-term NPK fertilization in northern China and subjected to polyphasic taxonomic study. The diamino acid of the cell-wall peptidoglycan found be meso -diaminopimelic sugars were xylose, glucose traces mannose. only respiratory quinone menaquinone 7 (MK-7). major cellular fatty acids iso-C 15 : 0 anteiso-C C 16 1 ω6 c /C ω7 . polar lipids...
Rapid rehabilitation surgery has become a widely accepted approach. Thoracic surgeons have attempted in many ways to make less invasive. We combined tubeless technology, single-port technology and mediastinum approach for the treatment of simultaneous bilateral primary spontaneous pneumothorax(PSP)or pulmonary bullae. And we evaluated its therapeutic effect. This study aimed investigate if video-assisted thoracic (Tubeless-SPVATS) via anterior can be used as an alternative surgical lung...
Abstract PurposeThis study aimed to investigate the relationship between miR-204-5p and Nestin in esophageal squamous cell carcinoma (ESCC). MethodsThe expression levels of were tested by quantitative real-time polymerase chain reaction (q-PCR) Western blotting, respectively. The colony formation assay was used assess proliferation. flow cytometry TUNEL examine apoptosis. Tumorigenesis evaluated using a murine xenograft tumor model. ResultsESCC tissues lines exhibited decreased increased...