A5044411516- Metabolism, Diabetes, and Cancer
- Advanced ceramic materials synthesis
- Cancer, Hypoxia, and Metabolism
- Cancer-related molecular mechanisms research
- Adipokines, Inflammation, and Metabolic Diseases
- Circular RNAs in diseases
- Traditional and Medicinal Uses of Annonaceae
- Power System Optimization and Stability
- RNA modifications and cancer
- Erythrocyte Function and Pathophysiology
- Endometrial and Cervical Cancer Treatments
- Alkaloids: synthesis and pharmacology
- Advanced materials and composites
- Lipoproteins and Cardiovascular Health
- Ferroelectric and Piezoelectric Materials
- Cancer-related gene regulation
- Peptidase Inhibition and Analysis
- Head and Neck Cancer Studies
- Microwave Dielectric Ceramics Synthesis
- Cancer, Lipids, and Metabolism
- Adipose Tissue and Metabolism
- Ubiquitin and proteasome pathways
- Advanced Algorithms and Applications
- Neonatal Health and Biochemistry
- Mitochondrial Function and Pathology
Chinese Academy of Sciences
1996-2025
Shandong First Medical University
2022-2025
Shandong University
2020-2025
Academy of Medical Sciences
2025
Beijing Academy of Artificial Intelligence
2025
Sun Yat-sen University
2016-2024
58.com (China)
2024
Inner Mongolia University of Science and Technology
2024
Guangzhou Medical University
2019-2024
Tianjin University
2023-2024
Abstract Oleic acid (OA), a main ingredient of Brucea javanica oil (BJO), is widely known to have anticancer effects in many tumors. In this study, we investigated the effect OA and its mechanism tongue squamous cell carcinoma (TSCC). We found that effectively inhibited TSCC proliferation dose- time-dependent manner. treatment significantly induced cycle G0/G1 arrest, increased proportion apoptotic cells, decreased expression CyclinD1 Bcl-2, p53 cleaved caspase-3. also obviously formation...
MicroRNAs have been proposed as novel biomarkers for the diagnosis and treatment of many types cancer. The levels five candidate microRNAs (miRNAs) (miR-99a-5p, miR-31-5p, miR-138-5p, miR-21-5p, miR-375-3p) in sera from oral cancer patients paired tumor normal tissues were detected by real-time qPCR. diagnostic power these miRNAs was analyzed receiver operating characteristic (ROC) curves. Patient-derived xenograft (PDX) models established utilized to verify potential therapeutic effect...
The visualization of drugs in living systems has become key techniques modern therapeutics. Recent advancements optical imaging technologies and molecular design strategies have revolutionized drug visualization. At the subcellular level, super-resolution microscopy allowed exploration landscape within individual cells cellular response to drugs. Moving beyond imaging, researchers integrated multiple modes, like near-infrared II study complex spatiotemporal interactions between their...
Pyruvate kinase isozyme type M2 (PKM2) catalyzes the final step in glycolysis and has been found to be up-regulated multiple human malignancies. However, whether PKM2 regulates radiosensitivity of cervical cancer (CC) remains unknown.The expression 94 patients with CC complete response (CR) noncomplete (nCR) groups, was evaluated by immunohistochemistry. The effect inhibition on radiosensitivity, cell cycle, DNA damage, apoptosis immunofluorescence analysis, colony formation assay, flow...
Aim: The aim of this study was to evaluate the prognostic significance preoperative systemic immune-inflammation index (SII) and establish a nomogram for prediction survival tongue squamous cell carcinoma (TSCC) patients who underwent primary surgery cervical dissection. Methods: 120 diagnosed with TSCC tumor neck dissection without treatment were included develop nomogram. This model externally validated in an independent data cohort 50 patients. X-tile software used identify optimal...
Background: The equilibrium between metabolic reserves and immune activation in critically ill patients is crucial for their short-term prognosis. FT4/WBC ratio couples the organism's metabolism with immunity. So far, scarce studies have concentrated on this ratio, machine learning (ML) models to predict 30-day mortality are lacking.Aims: This study aimed explore correlation of risk all-cause develop machine-learning outcomes ratio.
Anemia is a potentially life-threatening blood disorder caused by an insufficient erythroblast volume in the circulatory system. Self-renewal failure of progenitors one key pathological factors leading to deficiency. However, there are currently no effective drugs that selectively target this process. In work, we present carbon dot (CP-CDs) derived from phytochemicals significantly promotes self-renewal for anemia therapy. As superoxide dismutase (SOD)-like nanozyme, CP-CDs activate hypoxia...
Abstract Mitochondrial quality control is paramount for cellular development, with mitochondrial electron flow (Mito‐EF) playing a central role in maintaining homeostasis. However, unlike visible protein entities, which can be monitored through chemical biotechnology, regulating by invisible entities such as Mito‐EF has remained elusive. Here, tracker (Mito‐EFT) four‐pronged probe design presented to elucidate the dynamic mechanisms of Mito‐EF's involvement control. Heightened aggregation...
Intracellular calcium (Ca 2+ ) is a crucial signaling molecule involved in multiple cellular processes. However, the functional role of Ca terminal erythropoiesis remains unclear. Here, we uncovered dynamics intracellular levels during mouse erythroid development. By using ionophore ionomycin, found that low are required for expansion progenitors, whereas higher led to differentiation and proliferation early‐stage erythroblasts. were then gradually reduced, which nuclear condensation...
Antimicrobial peptides SAAP-148 exhibited excellent antimicrobial activities but suffered from inherent disadvantages, including cytotoxicity and poor proteolytic stability. Herein, we developed a novel strategy combining one unique silver-catalyzed solid-phase glycosylation-enabled arginine N-glycosylation all-hydrocarbon peptide double-stapling, five-round libraries were rationally constructed containing over 50 stapled and/or N-glycosylated peptides. SLP-51 consisting of two introduced...
Abstract Arecoline, the main alkaloid of areca nut, is well known for its role in inducing submucosal fibrosis and oral squamous cell carcinoma (OSCC), however mechanism remains unclear. The aim this study was to establish an arecoline‐induced epithelial‐mesenchymal transformation (EMT) model OSCC cells investigate underlying mechanisms. CAL33 UM2 were induced with arecoline EMT perform RNA‐sequence screening. Luminex multiplex cytokine assays, western blot, RT‐qPCR used mechanism. Arecoline...
Lipid metabolism is essential for stemness maintenance, self-renewal, and differentiation of stem cells, however, the regulatory function cholesterol in erythroid poorly studied. In present study, a critical role homeostasis terminal erythropoiesis uncovered. The master transcriptional factor GATA1 binds to Sterol-regulatory element binding protein 2 (SREBP2) downregulate biosynthesis, leading gradual reduction intracellular levels. It further shown that reduced functions block proliferation...
Chemerin, which is encoded by retinoic acid receptor responder 2 (RARRES2), has been found to be related malignant tumours, but its role in the development of oral squamous cell carcinoma (OSCC) largely unexplored. In present study, a higher serum level chemerin was evident patients with OSCC than healthy individuals, and this high significantly decreased after tumour resection. addition, levels were positively associated advanced stage lymph node metastasis. The expression Chemerin Receptor...
In this study, we evaluated the expressions and functions of a long noncoding RNA (lncRNA), Noncoding activated by DNA damage (NORAD) in human osteosarcoma. NORAD were qRT-PCR vitro osteosarcoma cell lines vivo clinical specimens. SiRNA-induced downregulation was conducted Saos-2 143B cells, functional effects on cells CCK-8 proliferation assay, 24-well transwell invasion assay tumor explant respectively. The possibility endogenously competing microRNA target, hsa-miR-199a-3p examined...