A5057814895- Antimicrobial Peptides and Activities
- Protein Hydrolysis and Bioactive Peptides
- Respiratory viral infections research
- Bacteriophages and microbial interactions
- Pneumonia and Respiratory Infections
- Biochemical and Structural Characterization
- Pediatric health and respiratory diseases
- Chemical Synthesis and Analysis
Shandong First Medical University
2025
Second Hospital of Shandong University
2025
Weifang Medical University
2024
Soochow University
2022
Antimicrobial peptides SAAP-148 exhibited excellent antimicrobial activities but suffered from inherent disadvantages, including cytotoxicity and poor proteolytic stability. Herein, we developed a novel strategy combining one unique silver-catalyzed solid-phase glycosylation-enabled arginine N-glycosylation all-hydrocarbon peptide double-stapling, five-round libraries were rationally constructed containing over 50 stapled and/or N-glycosylated peptides. SLP-51 consisting of two introduced...
Figainin 2 is a cationic, hydrophobic, α‐helical host‐defense peptide with 28 residues, which was isolated from the skin secretions of Chaco tree frog. It shows potent inhibitory activity against both Gram‐negative and Gram‐positive pathogens has garnered considerable interest in developing novel classes natural antibacterial agents. However, as linear peptide, conformational flexibility poor proteolytic stability hindered its development agent. To alleviate susceptibility to degradation...
Objective: To describe the clinical characteristics of Mycoplasma pneumoniae infection and analyze factors associated with co-infections other pathogens in children, provide evidence for improvement community acquired pneumonia (CAP) prevention control children. Methods: Based on surveillance hospitalized acute respiratory infections cases conducted Soochow University Affiliated Children's Hospital (SCH), CAP aged <16 years SCH between 2018 2021 were screened. The pathogenic test results...