A5101672725- Bladder and Urothelial Cancer Treatments
- Urinary and Genital Oncology Studies
- Renal cell carcinoma treatment
- Adrenal and Paraganglionic Tumors
- Prostate Cancer Diagnosis and Treatment
- Urological Disorders and Treatments
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Cancer, Hypoxia, and Metabolism
- Urinary Bladder and Prostate Research
- Hormonal and reproductive studies
- Pituitary Gland Disorders and Treatments
- Lymphoma Diagnosis and Treatment
- Ferroptosis and cancer prognosis
- Epigenetics and DNA Methylation
- Prostate Cancer Treatment and Research
- Ureteral procedures and complications
- RNA Research and Splicing
- Genital Health and Disease
- Peptidase Inhibition and Analysis
- Sexual function and dysfunction studies
- Cancer-related gene regulation
- Renal and related cancers
- PI3K/AKT/mTOR signaling in cancer
- Urologic and reproductive health conditions
Ruijin Hospital
2013-2025
Shanghai Jiao Tong University
2012-2025
Shanghai Institute of Hematology
2023-2025
Tongji University
2018-2024
Shanghai Tenth People's Hospital
2018-2024
Fudan University
2019-2024
Guangxi Medical University
2024
University of Pittsburgh
2022
Renji Hospital
2022
Sun Yat-sen University
2019
Alterations in lipid metabolism have the potential to be markers as well drivers of pathobiology acute critical illness. Here, we took advantage temporal precision offered by trauma a common cause illness identify dynamic patterns circulating lipidome critically ill humans. The major findings include an early loss all classes lipids followed delayed and selective lipogenesis patients destined remain ill. previously reported survival benefit thawed plasma administration was associated with...
Objectives: To develop reliable nomograms to estimate individualized overall survival (OS) and cancer specific (CSS) for patients with primary small cell carcinoma of the bladder (SCCB) compare predictive value AJCC stages. Patients Methods: 582 eligible SCCB identified in Surveillance, Epidemiology, End Results (SEER) dataset were randomly divided into training (n=482) validation (n=100) cohorts. Akaike information criterion was used select clinically important variables multivariate Cox...
Accumulating evidence indicates that cryptochrome circadian regulatory (CRY) proteins have emerged as crucial regulators of osteogenic differentiation. However, the associated mechanisms are quite elusive. In this study, we show knockdown CRY2 downregulated expression runt-related transcription factor 2 (Runx2), alkaline phosphatase (ALP), osteocalcin (OCN), and osteopontin (OPN) to facilitate osteoblast Further study identified was directly targeted by microRNA (miR)-7-5p, which highly...
Background: We aimed to evaluate the prognostic value of site-specific metastases in patients with metastatic bladder cancer and analyze roles that surgeries play treatment this malignancy. Materials methods: A population-based retrospective study using Surveillance, Epidemiology End Results dataset was performed were classified according sites (bone, brain, liver, lung distant lymph nodes). Kaplan–Meier analysis log-rank test used for survival comparisons. Multivariate Cox regression model...
To investigate the accuracy of using Vesical Imaging-Reporting and Data System (VI-RADS) scoring system in prediction preoperative muscle invasion bladder cancer.The study retrospectively reviewed consecutive patients with cancer who received multiparametric magnetic resonance imaging (MRI) between January 2017 June 2019. Clinical pathological parameters were collected. Bladder tumors re-evaluated 5-point VI-RADS by two experienced radiologists independently. The score was compared...
// Tianyuan Xu 1, * , Liang Qin Zhaowei Zhu 2 Xianjin Wang 1 Yue Liu 3 Yong Fan Shan Zhong Xiaojing Xiaohua Zhang Leilei Xia Xiang Chen Zhoujun Shen Department of Urology, Ruijin Hospital, School Medicine, Shanghai Jiaotong University, Shanghai, China The First Affiliated Hospital Zhengzhou Zhengzhou, Key Laboratory Reproductive These authors contributed equally to this work Correspondence to: Shen, email: shenzj68@sina.cn Keywords: microRNA-31, integrin α5, bladder cancer, chemotherapy,...
The insulin‐like growth factor receptor I (IGF‐IR) is a proto‐oncogene with potent mitogenic and antiapoptotic activities. It has been reported that expression of IGF‐IR up‐regulated in bladder cancer. Here, we assessed whether microRNA‐145 (miR‐145) regulates In our study, miR‐145 was shown to directly target 3′‐untranslated region (UTR) human cancer cells. Small interfering RNA (siRNA)‐ miR‐145‐mediated knockdown experiments revealed promotes cell apoptosis, suppresses proliferation...
Mounting studies show that long noncoding RNAs (lncRNAs) could affect human cancer progression, including bladder (BCa). LncRNA DiGeorge syndrome critical region gene 5 (DGCR5) has been proven to be involved in lung cancer, pancreatic ductal adenocarcinoma, and hepatocellular carcinoma. However, the function of DGCR5 BCa remains largely unknown. Here, we found expression was significantly downregulated tissues compared with adjacent normal tissues. Higher predicted higher survival rate...
Abstract Inflammation is pivotal in the pathogenesis and progression of most challenging diseases even cancer. Nanomedicine‐based strategy can be referred as a distinct solution to this complicated clinical obstacle by proposing an elaborated combination effective therapeutic performances on inflammation Herein, 2,2,6,6‐tetramethylpiperidine‐1‐oxyl doped polydopamine nanoparticles, termed TPDA NPs, with significantly improved reactive oxygen/nitrogen species (RO/NSs) scavenging performance...
To compare operative outcomes of robot-assisted radical prostatectomy (RARP) in obese and nonobese patients with prostate cancer.A literature search MEDLINE, EMBASE, Google Scholar, the Cochrane Library was performed up to March 2014. All studies that have assessed RARP were included. Outcome measures perioperative functional results, including operating time, estimated blood loss (EBL), complications, length hospital stay (LOS), positive surgical margins (PSMs), recovery continence potency....
The treatment and prognosis for muscle-invasive bladder cancer (MIBC) non-muscle-invasive (NMIBC) are different. We aimed to construct a nomogram based on the multiparametric MRI (mpMRI) radiomics signature Vesical Imaging-Reporting Data System (VI-RADS) score preoperative differentiation of MIBC from NMIBC.The retrospective study involved 185 pathologically confirmed (BCa) patients (training set: 129 patients, validation 56 patients) who received mpMRI before surgery between August 2014...
Abstract Immunomodulatory agent lenalidomide is effective in treating follicular lymphoma (FL). We conducted the first trial of immunotherapy rituximab plus newly diagnosed FL China (NCT03715309). One-hundred and fifteen patients were enrolled treated with 375 mg/m 2 intravenously on day 0 25 mg orally 1–10 for 6 cycles induction treatment, as well 8 maintenance treatment. found that inferior progression-free survival was significantly associated elevated serum β2m lymph node >6 cm,...
<b><i>Objective:</i></b> The purpose of this study was to evaluate the impact hypokalemia on hypertension outcomes in patients with aldosterone-producing adenoma (APA) after adrenalectomy and determine factors affecting complete cure a large series. <b><i>Methods:</i></b> Characteristics from 376 APA treated between 2005 2011 were collected our center. Factors assessed using logistic regression. <b><i>Results:</i></b> At...