A5020759583- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Flavonoids in Medical Research
- RNA Research and Splicing
- Cancer, Hypoxia, and Metabolism
- Epigenetics and DNA Methylation
- Mitochondrial Function and Pathology
- MicroRNA in disease regulation
- RNA and protein synthesis mechanisms
- Traditional Chinese Medicine Analysis
- Neuroscience and Neuropharmacology Research
- Birth, Development, and Health
- Testicular diseases and treatments
- Neurogenetic and Muscular Disorders Research
- Caveolin-1 and cellular processes
- RNA regulation and disease
- DNA Repair Mechanisms
- Metabolomics and Mass Spectrometry Studies
- Peptidase Inhibition and Analysis
- Circular RNAs in diseases
- Wnt/β-catenin signaling in development and cancer
- Water Resources and Sustainability
- Burn Injury Management and Outcomes
- Biosimilars and Bioanalytical Methods
- Macrophage Migration Inhibitory Factor
The University of Texas Southwestern Medical Center
2020-2025
Sichuan University
2025
The First People's Hospital of Changde
2025
Central South University
2025
Shanghai Jiao Tong University
2009-2024
Renji Hospital
2024
Zhejiang Chinese Medical University
2024
XinHua Hospital
2023
Southwestern Medical Center
2020-2022
Yueyang Hospital
2021
Hypoxia induces a vast array of long noncoding RNAs (lncRNA) in breast cancer cells, but their biological functions remain largely unknown. Here, we identified hitherto uncharacterized hypoxia-induced lncRNA RAB11B-AS1 cells. is natural upregulated human and its expression induced by hypoxia-inducible factor 2 (HIF2), not HIF1, response to hypoxia. enhanced the angiogenic factors including VEGFA ANGPTL4 hypoxic cells increasing recruitment RNA polymerase II. In line with increased factors,...
Abstract Since most variants that impact polygenic disease phenotypes localize to non-coding genomic regions, understanding the consequences of regulatory element will advance human mechanisms. Here, we report systemic lupus erythematosus (SLE) risk variant rs2431697 as likely causal for SLE through disruption a element, modulating miR-146a expression. Using epigenomic analysis, genome-editing and 3D chromatin structure show tags cell-type dependent distal enhancer specific physically...
Myocardial infarction (MI) elicits cardiac fibroblast activation and extracellular matrix (ECM) deposition to maintain the structural integrity of heart. Recent studies demonstrate that Fap (fibroblast protein)-a prolyl-specific serine protease-is an important marker activated fibroblasts after MI.Left ventricle plasma samples from patients healthy donors were used analyze expression level FAP its prognostic value. Echocardiography histological analysis heart sections functions, scar...
Abstract Branched-chain amino acid transaminase 1 (BCAT1) is upregulated selectively in human isocitrate dehydrogenase (IDH) wildtype (WT) but not mutant glioblastoma multiforme (GBM) and promotes IDHWT GBM growth. Through a metabolic synthetic lethal screen, we report here that α-ketoglutarate (AKG) kills cells when BCAT1 protein lost, which reversed by reexpression of or supplementation with branched-chain α-ketoacids (BCKA), downstream products BCAT1. In patient-derived tumors vitro vivo,...
Despite strong evidence that human genetic variants affect the expression of many key transcription factors involved in autoimmune diseases, establishing biological links between non-coding risk and gene targets they regulate remains a considerable challenge. Here, we combine genetic, epigenomic, CRISPR activation approaches to screen for functional IRF8 expression. We demonstrate locus containing rs2280381 is cell-type-specific enhancer spatially interacts with promoter. Further, mediates...
There are two known mRNA degradation pathways, 3′ to 5′ and 3′. We identified likely pathogenic variants in genes involved these pathways individuals with intellectual disability. In a large family multiple branches, we biallelic DCPS three affected individuals; splice site variant (c.636+1G>A) that results an in-frame insertion of 45 nucleotides missense (c.947C>T; p.Thr316Met). decaps the cap structure generated by exonucleolytic mRNA. vitro decapping assays showed ablation function for...
Abstract Diabetic periodontitis presents a unique therapeutic challenge, primarily due to its chronic inflammatory profile and the associated bone loss driven by immune dysregulation. Metformin (Met) is recognized for potent anti‐inflammatory properties, yet limited cellular uptake has hindered clinical effectiveness in diabetic periodontitis. A tetrahedral framework nucleic acid (tFNA)‐based delivery system developed enhance Met investigate effects on this study. The tFNA‐loaded complex...
Genetic mutations in apoptosis-inducing factor (AIF) have a strong association with mitochondrial disorders; however, little is known about the aberrant splicing variants affected patients and how these contribute to dysfunction brain development defects. We identified pathologic AIF3/AIF3-like postmortem tissues of pediatric individuals disorders. Mutations AIFM1 exon-2/3 increase risks. AIF3-splicing disrupts complexes, membrane potential, respiration, causing Mechanistically, AIF...
The scavenger decapping enzyme DcpS is a multifunctional protein initially identified by its property to hydrolyze the resulting cap structure following 3′ end mRNA decay. In Saccharomyces cerevisiae , homolog Dcs1 an obligate cofactor for 5′-3′ exoribonuclease Xrn1 while Caenorhabditis elegans Dcs-1, facilitates mediated microRNA turnover. both cases, this function independent of activity. Whether and activity can affect steady state or stability in mammalian cells remains unknown. We...
Abstract: Myogenic fate determination is important in skeletal muscle development, growth and repair. A variety of factors regulate myogenic cell via transcriptional non-transcriptional mechanisms. Amongst these factors, long noncoding RNAs (lncRNAs) have gained considerable attention for their roles regulating differentiation function. Many classes lncRNAs been discovered; various implicated the regulation are subject this brief review.
Antifreeze peptides regulate the physiological functions of frozen cells and even their apoptosis; however, mechanisms by which antifreeze these processes remain unclear, although interactions between cell membranes ice are well known to be important in this process.
Abstract Poly(ADP-ribose) polymerase-1 (PARP-1) is a DNA damage sensor and contributes to both repair cell death processes. However, how PARP-1 signaling regulated switch its function from remains largely unknown. Here, we found that plays central role in alkylating agent-induced PARthanatic cancer death. Lysine demethylase 6B (KDM6B) was identified as key regulator of PARthanatos. Loss KDM6B protein or activity conferred resistance response agents. Mechanistically, knockout suppressed...
Transmembrane proteins (TMEMs), spanning the entire width of lipid bilayers and anchored to them permanently, exist in diverse cell types implement a series essential physiological functions. Recently, TMEM48, member TMEM family, has been demonstrated be closely associated with tumorigenesis. However, little is known about specific role TMEM48 cervical cancer (CC). This study aimed investigate biological functions CC. The CCK-8 assay was performed detect CC proliferation. wound healing...