A5057158876- Alzheimer's disease research and treatments
- Frailty in Older Adults
- Nicotinic Acetylcholine Receptors Study
- Dementia and Cognitive Impairment Research
- Redox biology and oxidative stress
- Neuroinflammation and Neurodegeneration Mechanisms
- Intensive Care Unit Cognitive Disorders
- Mycotoxins in Agriculture and Food
- Sirtuins and Resveratrol in Medicine
- Tryptophan and brain disorders
- MicroRNA in disease regulation
- Biochemical effects in animals
- Cognitive Functions and Memory
- Long-Term Effects of COVID-19
- Geriatric Care and Nursing Homes
- COVID-19 and Mental Health
- Studies on Chitinases and Chitosanases
The Affiliated Yongchuan Hospital of Chongqing Medical University
2022-2025
Chongqing Medical University
2022-2025
Chongqing University of Science and Technology
2025
Chongqing Three Gorges University
2024
Chongqing University
2023-2024
Alzheimer's disease (AD) is the leading cause of dementia and presents a considerable burden. Its pathology involves substantial neuronal loss, primarily attributed to apoptosis. Although sirtuin 4 (SIRT4) has been implicated in regulating apoptosis various diseases, role SIRT4 AD remains unclear. The study used APP/PS1 mice as an animal model amyloid-β (Aβ)1-42-treated HT-22 cells cell model. expression was determined by quantitative real-time polymerase chain reaction, Western blot,...
Abstract Chitinase 1 (CHIT1), as a chitin‐specific hydrolase, significantly influences the progression of Alzheimer's disease (AD) through microglia‐associated inflammation and amyloid beta (Aβ) plaque accumulation. However, precise mechanism CHIT1 action in AD remains uncertain. The effects on cerebral blood flow (CBF), hippocampal volume, cognitive function were investigated APP/PS1 mice. Protein alterations resulting from overexpression analyzed using four‐dimensional (4D) label‐free...
The follow-up study on neuropsychiatric changes after the lifting of coronavirus disease 2019 (COVID-19) quarantine in patients with cognitive impairment and their caregivers is still lacking, relative information needed to formulate more comprehensive healthcare prevention measures worldwide.To provide data performance COVID-19 disorders caregivers.Two surveys Chongqing, China were conducted via telephonic interview 531 caregivers. baseline survey was performed from February 11 23, 2020,...
Based on readily available demographic data, neuropsychological assessment results, and comorbidity we aimed to develop validate a 3-year survival prediction model for patients with cognitive impairment.In this prospective cohort study, 616 impairment were included. Demographic information, data comorbidities, scores of the Mini-Mental State Examination (MMSE), Instrumental Activities Daily Living (IADL) scale, Neuropsychiatric Inventory Questionnaire collected. Survival status was...
Abstract Background To develop and validate a prediction model for the 3‐year survival of patientwith cognitive impairment based on demographics, neuropsychological assessment data, comorbidities. Method Five‐hundred‐and‐eighty‐seven patients with were included from our memory clinic. Demographic information, comorbidities, Mini‐Mental State Examination (MMSE), Instrumental Activity Daily Living (IADL) score, Neuropsychiatric Inventory Questionnaire sub‐item scores collected. Survival...