A5100398443- Dementia and Cognitive Impairment Research
- Functional Brain Connectivity Studies
- Advanced MRI Techniques and Applications
- Epilepsy research and treatment
- Nutrition and Health in Aging
- Retinal and Optic Conditions
- Atomic and Subatomic Physics Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Neural dynamics and brain function
- Frailty in Older Adults
- EEG and Brain-Computer Interfaces
- Blood Pressure and Hypertension Studies
- Geriatric Care and Nursing Homes
- Neurobiology of Language and Bilingualism
- Radiomics and Machine Learning in Medical Imaging
- Plasma Applications and Diagnostics
- Nitric Oxide and Endothelin Effects
- Alzheimer's disease research and treatments
- Gut microbiota and health
- Catalytic Processes in Materials Science
- Plasma Diagnostics and Applications
- Head and Neck Surgical Oncology
- Retinal Imaging and Analysis
- Venous Thromboembolism Diagnosis and Management
- Optical Imaging and Spectroscopy Techniques
The Affiliated Yongchuan Hospital of Chongqing Medical University
2019-2025
Chongqing Medical University
2017-2025
Peking University
2019-2025
Jiangsu University
2024
Affiliated Hospital of Jiangsu University
2024
University of California, Irvine
2024
United Hospital
2011-2023
Peking University People's Hospital
2019-2023
Minnesota Epilepsy Group
2005-2023
University of Science and Technology Beijing
2023
Network hyperexcitability may contribute to cognitive dysfunction in patients with Alzheimer disease (AD).To determine the ability of antiseizure drug levetiracetam improve cognition persons AD.The Levetiracetam for Alzheimer's Disease-Associated Hyperexcitability (LEV-AD) study was a phase 2a randomized double-blinded placebo-controlled crossover clinical trial 34 adults AD that conducted at University California, San Francisco, and Minnesota, Twin Cities, between October 16, 2014, July 21,...
Glioma is the most common primary central nervous system tumor, accounting for about half of all intracranial tumors. As a non-invasive examination method, MRI has an extremely important guiding role in clinical intervention However, manually segmenting brain tumors from requires lot time and energy doctors, which affects implementation follow-up diagnosis treatment plans. With development deep learning, medical image segmentation gradually automated. are easily confused with strokes serious...
The complex pathophysiology of epilepsy hampers the development effective treatments. Although more than ten kinds anti-seizures drugs (ASDs) have good effects on seizure control worldwide, about 30% patients still display pharmacoresistance against ASDs. Neuroinflammation seems to play a crucial role in disease progression. G protein-coupled receptor 120 (GPR120) has been shown negatively regulate inflammation and apoptosis. However, GPR120 remains unclear. In this study, we aimed explore...
Hypoxia preconditioning has been confirmed as an effective strategy to enhance the therapeutic potentials of mesenchymal stem cells (MSCs), such for myocardial ischemia. However, whether hypoxia would produce beneficial effects on MSC-based renal repair not demonstrated. In study, we aimed determine feasibility and efficacy therapy acute kidney injury (AKI). MSCs were isolated from human adipose tissues. The paracrine under normoxia determined in vitro . Rats AKI induced by I/R surgery...
Context: Ligustrazine (Lig) is a compound isolated from the rhizome of Ligusticum chuanxiong Hort. (Umbelliferae) and has been reported to be effective for treatment variety vascular diseases.Objective: The anti-atherosclerotic activities Lig are evaluated in vivo first time present study.Materials methods: We gave rats single injection vitamin D3 then fed them with an atherogenic diet 6 weeks induce atherosclerosis. was simultaneously given by gavage at dose 20 or 80 mg/kg therapy groups....
Combined source-imaging techniques and directional connectivity analysis can provide useful information about the underlying brain networks in a noninvasive fashion. Source-imaging have been used successfully to either determine source of activity or extract time-courses for Granger causality analysis, previously. In this work, we utilize algorithms both find network nodes [regions interest (ROI)] then activation time series further analysis. The aim work is objectively from electromagnetic...
Acute pancreatitis (AP) is a type of digestive system disease with high mortality. Previous studies have shown that gut microbiota can participate in developing and treating acute by affecting the host's metabolism. In this study, we followed 20 AP patients to generate longitudinal profiles activity during (before treatment, on third day 1 month after discharge). We analyzed species composition metabolic pathways' changes across treatment phase, severity, etiology. The diversity microbiome...
Abstract Chitinase 1 (CHIT1), as a chitin‐specific hydrolase, significantly influences the progression of Alzheimer's disease (AD) through microglia‐associated inflammation and amyloid beta (Aβ) plaque accumulation. However, precise mechanism CHIT1 action in AD remains uncertain. The effects on cerebral blood flow (CBF), hippocampal volume, cognitive function were investigated APP/PS1 mice. Protein alterations resulting from overexpression analyzed using four‐dimensional (4D) label‐free...
Magnetoencephalography (MEG)/magnetic source imaging (MSI) is a noninvasive functional neuroimaging procedure used to localize language-specific regions in the brain. The Wada test, or intracarotid amobarbital (IAP), gold standard determining speech/language lateralization for presurgical planning, although it invasive and associated with morbidity. purpose of this study provide further validation on use MSI language by comparing results against IAP.The sample consisted 35 patients epilepsy...
Abstract Aim This study aimed to elucidate whether malnutrition is associated with cognitive impairment in an older Chinese population. Methods A cross‐sectional was conducted 2365 participants aged 60 years or from January 2013 September 2019. Nutritional status measured by using the Mini Assessment Short Form (MNA‐SF). Cognitive function assessed Mini‐Mental State Examination (MMSE). The relationship between each domain and examined univariate multivariate logistic regression analysis....
As a highly malignant tumor, the incidence and mortality of glioma are not optimistic. Predicting survival time patients with by extracting feature information from gliomas is beneficial for doctors to develop more targeted treatments. Magnetic resonance imaging (MRI) way quickly clearly capture details brain tissue. However, manually segmenting tumors MRI will cost lot energy, can only vaguely estimate patients, which conducive formulation treatment plans. Therefore, automatically...
Event-related magnetic fields were recorded using magnetoencephalography in children with (n=12) and without (n=11) dyslexia while they discriminated between pairs of syllables from a voice onset time series (/ga/-/ka/). Nonimpaired readers exhibited left-hemisphere predominance activity after the resolution N1m, whereas experienced sharp peak relative activation right temporoparietal areas 300 700 ms post-stimulus onset. Increased was correlated reduced performance on phonological...
Preterm birth is a global health issue. The association between fertility treatment and preterm singleton births has not been clarified.To examine the birth.This population-based cohort study used data that were submitted by 50 states District of Columbia to National Vital Statistics System database. All mothers in database who had live from January 1, 2016, December 31, 2019, included. Those preexisting hypertension or diabetes excluded.Fertility categorized as assisted reproductive...
COVID-19 is erupting globally. Mass quarantine had been implemented all around China which could influence the psychological status of patients with memory disorders and their caregivers. To investigate impact mass on caregivers in China. We completed a cross-sectional study 787 registered from 2010 to 2019 Memory Clinic, The First Affiliated Hospital Chongqing Medical University, by telephone interviews. performance neuropsychiatric symptoms (NPSs), sleep, nutrition, chronic diseases...
Abstract Background Cognitive decline and neuropsychiatric symptoms (NPS) are main clinical manifestations in Alzheimer disease (AD). It is unclear whether the link between specific NPS cognitive domains exists AD or mild impairment (MCI). Our study aimed to examine association domain MCI, evaluate this showed variety different stages of impairment. Methods A total 458 patients diagnosed as MCI were included study. Neuropsychological batteries applied The function evaluated by multiple...
To investigate the effects of sport stacking on overall cognition and brain function in patients with mild Alzheimer's disease (AD) cognitive impairment (MCI).A single-blind randomized controlled design was performed using for 30 min, 5 days/week 12 weeks. Forty-eight subjects AD or MCI were randomly divided into group (T-mAD = 12, T-MCI 12) active control (C-mAD 11, C-MCI 13). Auditory Verbal Learning Test (AVLT), Disease Cooperative Study-Activities Daily Living scale (ADCS-ADL), Geriatric...
Epilepsy is a common neurological disease, and excessive mitophagy considered as one of the major triggers epilepsy. Mitophagy crucial pathway affecting reactive oxygen species. Phosphoglycerate mutase 5 (PGAM5) protein phosphatase present in mitochondria that regulates many biological processes including cell death. However, mechanism PGAM5 epilepsy remains unclear. The purpose study was to examine whether affects through PTEN-induced putative kinase 1 (PINK1)-mediated mitophagy. After...
Background: Rapidly growing healthcare demand associated with global population aging has spurred the development of new digital tools for assessment cognitive performance in older adults. Objective: To develop a fully automated Mini-Mental State Examination (MMSE) model and validate model’s rating consistency. Methods: The Automated Assessment Model MMSE (AAM-MMSE) was an about 10-min computerized screening tool containing same questions as traditional paper-based Chinese MMSE. validity...
Object. Magnetoencephalography (MEG) is a novel noninvasive diagnostic tool used to determine preoperatively the location of epileptogenic zone in patients with epilepsy. The presence focal slowing activity recorded by electroencephalography (EEG) an additional indicator underlying pathological condition cases intractable mesial temporal lobe epilepsy (MTLE). In present study authors examined significance focal, slow-wave and interictal spike detected using MEG 29 who suffered from MTLE that...