A5028218242- Gut microbiota and health
- Clostridium difficile and Clostridium perfringens research
- Gastrointestinal motility and disorders
- Helicobacter pylori-related gastroenterology studies
- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Pancreatitis Pathology and Treatment
- Gastric Cancer Management and Outcomes
- Diet, Metabolism, and Disease
- Pancreatic and Hepatic Oncology Research
- Infant Health and Development
- Diet and metabolism studies
- Gastroesophageal reflux and treatments
- Colorectal Cancer Screening and Detection
- Immune Cell Function and Interaction
- Dermatology and Skin Diseases
- Child Nutrition and Feeding Issues
- Gastrointestinal disorders and treatments
- Dietary Effects on Health
- Autism Spectrum Disorder Research
- Macrophage Migration Inhibitory Factor
- IL-33, ST2, and ILC Pathways
- Eosinophilic Esophagitis
- Diabetes and associated disorders
- Hepatitis B Virus Studies
First Affiliated Hospital of Guangdong Pharmaceutical University
2013-2025
Guangdong Pharmaceutical University
2009-2025
First Affiliated Hospital of Jinan University
2021-2024
People's Liberation Army No. 150 Hospital
2024
Key Laboratory of Guangdong Province
2023
Central South University
2020
Xiangya Hospital Central South University
2020
First Affiliated Hospital of Soochow University
2011-2016
Soochow University
2011-2016
Second Affiliated Hospital of Guangzhou Medical University
2004-2015
The clinical efficacy of fecal microbiota transplantation (FMT) in patients with non-alcoholic fatty liver disease (NAFLD) and the variant effects FMT on lean obese NAFLD remain elusive. Our study aimed to determine safety for NAFLD, elucidating its different influences NAFLD.
Inflammatory phenotypes are recognised in stable adult asthma, but less well established childhood and acute asthma. Additionally, Chlamydophila pneumoniae infection as a cause of noneosinophilic asthma is controversial. This study examined the prevalence inflammatory presence current C. adults children with Adults (n=29) or (n=22) healthy (n=11), (n=49) (n=28) (n=9) underwent clinical assessment sputum induction. Sputum was assessed for cells, DNA extracted from cell suspensions...
While fecal microbiota transplantation is demonstrated to improve symptoms of autism spectrum disorder (ASD), it remains unclear whether additional treatment courses yield better results. This study sought evaluate the efficacy repeated washed (WMT) in children with ASD.Retrospective data from who were serially treated WMT, including ASD symptoms, sleep disorders, gastrointestinal (GI) and white blood cell (WBC) globulin levels obtained. The effect WMT on led a further improvement...
A growing body of evidence implicates macrophage migration inhibitory factor (MIF) in tumorigenesis and metastasis. In this study, we investigated whether MIF expression was associated with clinicopathologic features colorectal carcinoma (CRC), especially tumors hepatic metastasis, neutralization endogenous using anti-MIF therapeutics would inhibit tumor growth and/or decrease the frequency metastases a mouse colon model. The concentration serum positively correlated an increased risk...
BACKGROUNDAlopecia areata is a hair loss disease associated with genetics, autoimmunity, and other factors.There an intriguing link between alopecia gut dysbiosis.Fecal microbiota transplantation (FMT) has been recommended to treat Clostridium difficile (previously known as Clostridioides difficile) infection, also shown potentials in the treatment of inflammatory bowel disease, irritable syndrome, non-alcohol fatty liver disease. CASE SUMMARYAn 86-year-old man, history sigmoid colon...
Although transplantation of the fecal microbiota from normotensive donors has been shown to have an antihypertensive effect in hypertensive animal models, its on blood pressure patients with hypertension is unclear. This study aimed assess washed (WMT) regulation patients.The clinical data consecutive treated were collected retrospectively. The pressures before and after WMT compared. factors influencing microbial composition also analyzed.WMT exhibited pressure: at hospital discharge was...
The Nod-like receptor protein 3 (NLRP3) inflammasome activation not only serves as an intracellular machinery triggering inflammation but also produces uncanonical effects beyond such changing cell metabolism and increasing membrane permeability. present study was designed to test whether this NLRP3 contributes the "two-hit" injury during nonalcoholic steatohepatitis (NASH) it can be a therapeutic target for action of Fufang Zhenzhu Tiaozhi (FTZ), widely used herbal remedy hyperlipidemia...
The γ-aminobutyric acid (GABA) hypothesis posits a role of GABA deficiency in the central nervous system pathogenesis and progression essential tremor (ET). However, specific causative factor for is not clear. gut microbiota mammals has recently been considered as significant source GABA. Furthermore, GABA-based signals originating from intestine can be transmitted to brain through "enteric system-vagus nerve-brain" axis. plausible contribution ET seems inspiring but remains obscure.
Acute pancreatitis (AP) is a type of digestive system disease with high mortality. Previous studies have shown that gut microbiota can participate in developing and treating acute by affecting the host's metabolism. In this study, we followed 20 AP patients to generate longitudinal profiles activity during (before treatment, on third day 1 month after discharge). We analyzed species composition metabolic pathways' changes across treatment phase, severity, etiology. The diversity microbiome...
Abstract Background Faecal microbiota transplantation holds promise in mitigating fat accumulation and improving obesity. This study aimed to evaluate the long‐term efficacy of washed (WMT) among overweight patients. Methods The clinical data pertaining treatment patients with WMT were collected retrospectively. Compared alterations body mass index (BMI), blood glucose, lipids pressure prior following treatment. Comprehensive evaluation atherosclerosis cardiovascular disease (ASCVD) grading...
Background and aims Metabolic Syndrome (MS) is a cluster of metabolic abnormalities closely associated with hypertension, diabetes, hyperlipidemia, obesity, etc. Our previous research indicated that fecal microbiota transplantation (FMT) could improve MS, but the factors influencing efficacy washed (WMT) in treating MS patients remain unclear. The objective this study to analyze WMT patients. Methods clinical data related were collected retrospectively. Not only changes body mass index [BMI...
Objective Washed microbiota transplantation (WMT) has emerged as a promising therapeutic strategy for autism spectrum disorder (ASD), though the factors that influence its efficacy remain poorly understood. This study explores impact of gastrointestinal (GI) symptoms on effectiveness WMT in ASD. Methods Clinical data encompassing ASD symptoms, GI disturbances, and sleep disorders were collected from patients with undergoing WMT. The contributing to assessed. Results significantly reduced...
Background Clinical and experimental research has revealed that diabetes mellitus (DM) is characterized by intestinal hypomotility, gut microbial dysbiosis, increased permeability, microcirculation disorders, circulatory changes, dysfunction of stem cells, which may be linked to inflammation mucosa. However, the relationship between type 2 DM (T2DM) macroscopic small mucosal injuries still unclear. Therefore, we retrospectively studied capsule endoscopy data determine T2DM injuries....
Metabolic syndrome (MS) is a growing public health problem worldwide. The clinical impact of fecal microbiota transplantation (FMT) from healthy donors in MS patients unclear, especially southern Chinese populations. This study aimed to investigate the effect washed (WMT) China.
Overweight (OW) and obesity have become increasingly serious public health problems worldwide. The clinical impact of washed microbiota transplantation (WMT) from healthy donors in OW patients is unclear. This study aimed to investigate the effect WMT patients.The changes body mass index (BMI = weight (kg)/height (m)2), blood glucose, lipids other indicators before after were compared. At same time, 16S rRNA gene amplicon sequencing was performed on fecal samples transplantation. Finally,...
Gut dysbiosis has been reported to be closely associated with gout. Washed microbiota transplantation (WMT) is considered as an effective way restore a healthy gut less adverse events than the conventional fecal transplantation. In this study, we aimed evaluate effects of WMT on serum uric acid levels, symptoms, and intestinal barrier function in patients acute recurrent gout.We performed pilot study for The primary outcome was changes level gout symptoms. secondary outcomes included levels...
Abstract Background Faecal microbiota transplantation (FMT) is an effective therapy for recurrent Clostridium difficile infections and chronic gastrointestional infections. However, the risks of FMT selection process suitable donors remain insufficiently characterized. The eligibility rate screening, underlying microbial basis, core ethical issues stool are yet to be elucidated in China. Results potential were screened from December 2017 2019 with help online survey, clinical assessments,...
Background and Aims Although fecal microbiota transplantation (FMT) from healthy donors has been shown to have hypoglycemic effects in animal models of diabetes, its clinical impact patients with abnormal blood glucose metabolism is unclear, especially southern Chinese populations. The aim this study was investigate the feasibility efficacy washed (WMT) treatment a population China. Methods data different indications who received 1-3 treatments WMT were retrospectively collected. changes...
Changes in the gut microbiota composition is a hallmark of chronic kidney disease (CKD), and interventions targeting present potent approach for CKD treatment. This study aimed to evaluate efficacy safety washed transplantation (WMT), modified faecal method, on renal activity patients with dysfunction.A comparative analysis profiles was conducted dysfunction healthy controls. Furthermore, WMT parameters evaluated, changes urinary metabolites after treatment were analysed.Principal coordinate...
Background: Previous studies have indicated an association between hypertension and intestinal barrier dysfunction in mice models. The present study aims to investigate the impairment humans identify novel potential risk factors for hypertension. Methods: Medical data from consecutive inpatients were retrospectively pooled patient records. We compared serum markers [diamine oxidase (DAO), lipopolysaccharide (LPS), D -lactate] those patients with without Moreover, associations cardiovascular...
Background and Aims Although the manual crude fecal microbiota transplantation (FMT) reduces blood lipids in animal models of hyperlipidemia, its clinical effect on lipid metabolism patients with hyperlipidemia hypolipidemia remains unclear, especially Chinese population. It was reported that washed (WMT) safer, more precise, quality-controllable than FMT by manual. This study aimed to investigate feasibility effectiveness WMT Methods Clinical data various indications who received for 1–3...