A5052819986- Helicobacter pylori-related gastroenterology studies
- Gastroesophageal reflux and treatments
- Eosinophilic Esophagitis
- Gastric Cancer Management and Outcomes
- Veterinary medicine and infectious diseases
- Liver Disease Diagnosis and Treatment
- Clostridium difficile and Clostridium perfringens research
- Galectins and Cancer Biology
- Gastrointestinal disorders and treatments
- Macrophage Migration Inhibitory Factor
- Gut microbiota and health
- Gastrointestinal motility and disorders
- Inflammatory mediators and NSAID effects
- Hepatitis B Virus Studies
- Hepatitis C virus research
- NF-κB Signaling Pathways
- interferon and immune responses
- Cytokine Signaling Pathways and Interactions
- IL-33, ST2, and ILC Pathways
- Hepatocellular Carcinoma Treatment and Prognosis
- Pediatric Hepatobiliary Diseases and Treatments
- Liver Diseases and Immunity
- Hypothalamic control of reproductive hormones
- scientometrics and bibliometrics research
- Alcohol Consumption and Health Effects
Nanchang University
2025
First Affiliated Hospital of Jiangxi Medical College
2025
Shenzhen Second People's Hospital
2025
First Affiliated Hospital of Guangdong Pharmaceutical University
2016-2024
Guangdong Pharmaceutical University
2016-2022
Sichuan University
2019
Qingdao University
2015
Qingdao Municipal Hospital
2015
Novartis (United States)
2008-2014
Novartis (Switzerland)
2008-2014
Summary Background : Population‐based data on gastro‐oesophageal reflux disease in Chinese are lacking. The prevalence, clinical spectrum and health care‐seeking behaviour of subjects with were studied. Methods Ethnic (3605) invited to participate a telephone survey using validated questionnaire the Hospital Anxiety Depression Scale. Results A total 2209 (58% female; mean age, 40.3 years) completed interview. annual, monthly weekly prevalence rates 29.8%, 8.9% 2.5%, respectively....
OBJECTIVES: %Helicobacter pylori is an identified carcinogen for gastric cancer, however, the underlying mechanisms remain to be defined. In this review, we sought elucidate role of apoptosis in carcinogenesis, determine influence H. infection on apoptosis, and finally provide insights into by which may lead carcinogenesis. METHODS: A broad-based MEDLINE Current Contents literature search was performed identify relevant publications between 1966 March 2000 addressing infection, cell...
BACKGROUNDAlopecia areata is a hair loss disease associated with genetics, autoimmunity, and other factors.There an intriguing link between alopecia gut dysbiosis.Fecal microbiota transplantation (FMT) has been recommended to treat Clostridium difficile (previously known as Clostridioides difficile) infection, also shown potentials in the treatment of inflammatory bowel disease, irritable syndrome, non-alcohol fatty liver disease. CASE SUMMARYAn 86-year-old man, history sigmoid colon...
Summary Aim : To test the efficacy of rabeprazole, levofloxacin and rifabutin triple therapy vs. quadruple for second‐line treatment Helicobacter pylori infection. Methods One hundred nine patients who had failed previous H. eradication were randomized to receive: (i) 20 mg b.d., rifabutin, 300 once daily, levofloxacin, 500 7 days (triple therapy); or (ii) metronidazole, 400 t.d.s., bismuth subcitrate, 120 q.d.s., tetracycline, (quadruple therapy). Endoscopy culture performed before...
Aspirin-induced apoptosis is one of the important mechanisms for its antitumour effect against gastric cancer. We aimed at investigating involvement bcl-2 family members in apoptotic pathway Gastric cancer cell line AGS and MKN-45 were observed as to growth inhibition induction response treatment with aspirin. Cell proliferation was measured by MTT assay. Apoptosis determined 4'-6-diamidino-2-phenylindole staining. Protein expression western blotting. showed that aspirin activated caspase-8,...
Summary Aims : To study the prevalence, clinical characteristics and long‐term outcome of oesophagitis in Chinese patients. Methods Clinical endoscopic data were collected prospectively from consecutive patients who underwent upper endoscopy between 1997 2001. Patients with graded according to Los Angeles system analysed their presentation, details, Helicobacter pylori status, non‐steroidal anti‐inflammatory drug history, co‐morbidity mortality. Results A total 22 628 endoscopies performed...
Previous studies have shown that an elevated triglyceride-glucose (TyG) index is associated with all-cause mortality in patients. However, the potential mediating effect of blood urea nitrogen (BUN) within these associations has not been reported. The focus this study was to investigate BUN associations. This a retrospective cohort patients eICU Collaborative Research Database (eICU-CRD) from 208 different ICUs United States between 2014 and 2015 explored. primary endpoint 28 days ICU...
Summary Background and aims: To develop a validated gastro‐oesophageal disease (GERD) symptom questionnaire for the Chinese population. Methods: One hundred patients with GERD 101 healthy controls were presented 20‐item in language (Chinese GERDQ). Quality of life was assessed by SF‐36. A standard dose proton pump inhibitors 4 weeks prescribed to 35 newly diagnosed GERD. The GERDQ performed before, 8 after treatment. Concept, content, construct, discriminant validity reliability assessed....
The relationship between Helicobacter pylori infection and symptoms remains controversial. We aimed to determine if an association exists unexplained dyspepsia (pain or discomfort centered in the upper part of abdomen) H pylori.A validated questionnaire was completed by 592 healthy blood donors. serologic values (via enzyme-linked immunosorbent assay), group status, Rh status were measured; 4.9% subjects who had a history peptic ulcer disease excluded from analyses.The prevalence no 11% (95%...
Summary Background: Peptic ulcer disease is mainly caused by Helicobacter pylori infection and the use of non‐steroidal anti‐inflammatory drugs. Aim: To investigate trends in prevalence peptic disease, H. drug uninvestigated dyspeptic patients over recent years Hong Kong. Methods: Data from consecutive with symptoms referred family physicians for open access upper endoscopy during 1997 2003 were analysed relation to use. Results: Among 2700 included, 405 (15%) had 14 (0.5%) gastric cancer....
Summary Aim : To determine whether symptomatic response to lansoprazole predicts abnormal acid reflux in endoscopy‐negative patients with non‐cardiac chest pain. Methods Patients who complained of pain, but had normal coronary angiography, were asked undergo upper endoscopy. Those without gastric and oesophageal lesions recruited for 24‐h ambulatory pH monitoring, randomly given 30 mg or placebo, both daily 4 weeks. Chest pain symptoms recorded before 1 month after treatment on a locally...
Abstract BACKGROUND: This study aimed to determine the potential diagnostic value of migration‐inhibitory factor (MIF) for gastric cancer in patients presenting with dyspepsia and its prognostic cancer. METHODS: A cohort 97 histologically confirmed adenocarcinoma 222 were recruited. Enzyme‐linked immunosorbent assay was used measure serum MIF carcinoembryonic antigen (CEA). RESULTS: The concentrations 6554.0 ± 204.1 pg/mL 1453.7 79.9 pg/mL, respectively, dyspeptic ( P < .001). Serum...
SUMMARY Background : Helicobacter pylori infection has been associated with growth restriction in young children. Aim To determine whether there is an association between H. and intrauterine restriction. Methods Four hundred forty‐eight consecutive pregnant women (aged 15–44 years), attending for routine examinations the third trimester, were enrolled. Clinical, demographic previous obstetric data, as well smoking history, collected. At delivery, weight, height, gender status of neonate...
Aims: To test the usefulness of upper gastrointestinal investigations and quality life assessment in Chinese patients with non‐cardiac chest pain. Methods: Seventy‐eight consecutive pain underwent endoscopy. Eight had pathology (10%). The remaining 70 received acid perfusion test, oesophageal manometry 24‐h ambulatory pH ( n =65)/manometry =61), results were compared those healthy controls =20). Symptoms (SF‐36) assessed by standard validated questionnaire. Results: Significant reflux...