A5101890247- Cardiovascular Function and Risk Factors
- Heart Failure Treatment and Management
- Cardiac pacing and defibrillation studies
- Cardiac Arrhythmias and Treatments
- Atrial Fibrillation Management and Outcomes
- Adipokines, Inflammation, and Metabolic Diseases
- Long-Term Effects of COVID-19
- Acute Myocardial Infarction Research
- Venous Thromboembolism Diagnosis and Management
- SARS-CoV-2 and COVID-19 Research
- Cardiac electrophysiology and arrhythmias
- MicroRNA in disease regulation
- Blood Coagulation and Thrombosis Mechanisms
- COVID-19 Clinical Research Studies
- Cancer-related molecular mechanisms research
- PARP inhibition in cancer therapy
- Ferroptosis and cancer prognosis
- Coronary Interventions and Diagnostics
- Heart rate and cardiovascular health
- Neurological Disease Mechanisms and Treatments
- Kruppel-like factors research
- Potassium and Related Disorders
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Autophagy in Disease and Therapy
- Signaling Pathways in Disease
Tongji University
2013-2025
Third Affiliated Hospital of Guangzhou Medical University
2025
Guangzhou Medical University
2025
Shanghai Tenth People's Hospital
2013-2024
Sichuan Agricultural University
2024
Rice Research Institute
2024
Sun Yat-sen University
2024
Sun Yat-sen Memorial Hospital
2024
Tongji Hospital
2022
Shanghai East Hospital
2022
Abstract Background Recent studies highlighted that stress hyperglycemia ratio (SHR) is a potential predictor for future risk in heart failure (HF) patients. However, its implications specifically HF with preserved ejection fraction (HFpEF) are not yet fully elucidated. We aimed to investigate the association between SHR and long-term clinical outcomes HFpEF Methods patients enrolled 2015 2023, were followed (mean 41 months) composite outcome of all-cause, cardiovascular mortality,...
Myocardial infarction (MI) elicits cardiac fibroblast activation and extracellular matrix (ECM) deposition to maintain the structural integrity of heart. Recent studies demonstrate that Fap (fibroblast protein)-a prolyl-specific serine protease-is an important marker activated fibroblasts after MI.Left ventricle plasma samples from patients healthy donors were used analyze expression level FAP its prognostic value. Echocardiography histological analysis heart sections functions, scar...
This study aimed to investigate the clinical utility of different soluble suppression tumorigenicity 2 (sST2) levels in assessing severity and prognosis patients with acute heart failure (AHF).This was a prospective cohort study. Three hundred thirty-one consecutively enrolled AHF from March 2018 November 2019 were divided into 3 subgroups according sST2 levels: T1 (1.15-7.70 ng/ml; N = 110), T2 (7.71-17.24 111), T3 (17.26-47.42 110). The followed up for median period 21.0 months development...
Mahuang Fuzi Xixin Decoction (MFX), a traditional Chinese medicine containing 44 volatile components (97.36% total oil), includes key compounds like α-terpenol (13.34%) and 1,2,3-trimethoxy-5-methyl-benzene (22.64%). Using network pharmacology Mendelian randomization, 24 active were identified targeting MS-related pathways (NF-κB, NLRP3, Toll-like receptor). Genetic variants in CYP450, GSK3B, CYBB, PON1 correlated with reduced MS risk. In EAE mice, MFX decreased spinal GSK-3B expression...
Background Circulating microRNAs are emerging biomarkers for heart failure (HF). Our study aimed to assess the prognostic value of microRNA signature that is differentially expressed in patients with acute HF. Methods and Results comprised a screening cohort 15 AHF 5 controls, PCR-discovery 50 26 controls validation 564 from registered DRAGON-HF (Diagnostic, Risk Stratification Prognostic Value Novel Biomarkers Patients With Heart Failure). Through by RNA-sequencing verification...
Aims: COVID-19 patients with comorbidities such as hypertension or heart failure (HF) are associated poor clinical outcomes. The cellular distribution of Angiotensin-converting enzyme 2 (ACE2), the critical for SARS-CoV-2 infection, in human is unknown. We explore underlying mechanism that leads to increased susceptibility cardiovascular diseases and cardiac dysfunction have risk multi-organ injury compared normal function. Methods Results: analyzed single-cell RNA sequencing (scRNA-seq)...
Abstract Background The combined procedure of left atrial appendage closure (LAAC) with concomitant pulmonary vein isolation (PVI) has demonstrated its efficacy and safety. However, there is still a lack comparative investigations regarding the long-term benefits when compared to LAAC alone. Our study aims assess outcomes PVI in comparison propensity matched alone group. Methods Propensity score matching (PSM) was employed rectify covariate imbalances, resulting inclusion 153 comparable...
Left atrial appendage morphology has been proved to be an important predictor of left thrombus (LAT) and spontaneous echo contrast (LASEC) stroke in patients with non-valvular fibrillation (NVAF). However, the relation between (LAA) lobes LAT or LASEC is still unknown. The aim this study investigate correlation number LAT/LASEC NVAF.This monocentric cross-sectional enrolled 472 consecutive fibrillation, who had transthoracic echocardiography (TTE) transesophageal (TEE) prior cardioversion...
Clear cell renal carcinoma (ccRCC) is a common malignancy with high distant metastasis rate. Long non-coding RNAs (LncRNAs) are reported to be upregulated or downregulated in multiple cancers and play crucial role the of tumors prognosis. Therefore, purpose our study construct prognostic signature for ccRCC based on metastasis-related lncRNAs explore involved potential competitive endogenous RNA (ceRNA) network. The differentially expressed genes (DEGs) screened from database cancer genome...
Abstract Background Growth arrest-specific 6 (GAS6) is a vitamin K-dependent protein related to inflammation, fibrosis, as well platelet function. Genetic ablation of GAS6 in mice protects against cardiac hypertrophy and dysfunction. Nonetheless, the association between plasma levels acute heart failure (AHF) patients still unknown. Methods We measured concentrations 1039 with AHF who were enrolled DRAGON-HF trial (NCT03727828). Mean follow-up study was 889 days. The primary endpoint...
Abstract The coronavirus disease 2019 (COVID-19) has resulted in high morbidity and mortality worldwide since December 2019. Recent studies showed that patients with previous heart disease, especially failure (HF), whose plasma Natriuretic Peptides (NPs) concentrations are higher, were more susceptible to SARS-CoV-2 infection. In this study, we retrospectively analyzed single-center case series of 91 COVID-19 China. 46 (50.5%) exhibited cardiac dysfunction as indicated by elevated B (BNP)...
Terfenadine is a second generation histamine receptor antagonist which widely used as non‑sedating antihistamine to relieve allergic responses. However, terfenadine has been associated with number of side effects on cardiac electrical activities through blocking multiple ion channels in the heart, particularly K+ channels. Previous studies have also implied that may potential antiarrhythmic effect; however, electrophysiological influence by exerts its action remains elusive. Based evidence...
Abstract Aims Elevated heart rate (HR) in failure (HF) is associated with worse outcomes, particularly acute HF (AHF). HR reduction ivabradine reduces cardiovascular events patients reduced ejection fraction. The present trial aimed to test the hypothesis that early using improves clinical outcomes AHF. Methods and results SHIFT‐AHF a prospective, multi‐centre, double‐blind, randomized, placebo‐controlled evaluate efficacy safety of when adding standard therapy AHF (SHIFT‐AHF). will include...
Abstract This study aimed to investigate the role of deubiquitinating enzyme 3 (DUB3) in regulation Krüppel-like factor 4 (KLF4) expression hepatocellular carcinoma (HCC). Gain- and loss-of-function assay, luciferase reporter co-immunoprecipitation, intracellular extracellular deubiquitination assays were conducted vitro. A tumor xenograft mouse model was established. The DUB3 KLF4 examined HCC patient specimens. results showed that upregulated by stabilizing protein cells through binding...
Introduction Selenium is an essential micronutrient the human body requires, which closely linked to health. Rice, a primary staple food globally, major source of selenium intake. To develop selenium-enriched rice varieties, it imperative understand mechanisms behind selenium’s absorption and transport within rice, alongside identifying key genes involved in uptake, transport, transformation plant. Methods This study conducted transcriptome sequencing on four types materials (two with...
Visceral adipose tissue-derived serine protease inhibitor (vaspin) is an adipocytokine with insulin-sensitizing effects. Accumulating data implied that vaspin represents a compensatory mechanism but it unknown how change during ageing. This study was designed to examine the correlation between plasma and age in group of normal Chinese people.A total 191 volunteers aged 19-80 years were enrolled into four groups based upon quartiles (19-35, 36-50, 51-65 66-80 years). Demographic,...
Hyponatremia is a risk factor associated with poor prognosis in patients heart failure (HF) reduced ejection fraction. However, whether hyponatremia has similar role HF preserved fraction (HFpEF) remained controversial. Therefore, the present study aimed to investigate clinical characteristics and 24‑month prognostic profile of cohort HFpEF China. From registered observational on 1,027 subjects HF, 496 were included. The association between baseline admission adverse outcomes (including...
Abstract To evaluate the association between circulating levels of inflammatory cytokines and occurrence post-percutaneous coronary intervention (PCI) slow flow (CSF) in patients with non-ST segment elevation acute syndrome (NSTE-ACS). CSF after PCI commonly occurs implies poor outcomes, while determinants post-PCI NSTE-ACS remain controversial. In this multicenter case control study, 176 diagnosed occurred composed group, 352 matched group. Corrected thrombolysis myocardial infarction frame...