A5014014218- Retinal Diseases and Treatments
- Glaucoma and retinal disorders
- Cardiac Imaging and Diagnostics
- Retinal Imaging and Analysis
- Antiplatelet Therapy and Cardiovascular Diseases
- Mechanical Circulatory Support Devices
- Cardiac Valve Diseases and Treatments
- Acute Myocardial Infarction Research
- Lipoproteins and Cardiovascular Health
- Neurological Disorders and Treatments
- Heme Oxygenase-1 and Carbon Monoxide
- Manufacturing Process and Optimization
- Acute Ischemic Stroke Management
- Circadian rhythm and melatonin
- Redox biology and oxidative stress
- Cerebrovascular and Carotid Artery Diseases
- Cardiac Structural Anomalies and Repair
- Coronary Interventions and Diagnostics
- Advanced machining processes and optimization
- Drug-Induced Ocular Toxicity
- Acupuncture Treatment Research Studies
- Pericarditis and Cardiac Tamponade
- Natural Products and Biological Research
- Cardiac Fibrosis and Remodeling
- Atherosclerosis and Cardiovascular Diseases
First Affiliated Hospital of Xi'an Jiaotong University
2015-2024
Ministry of Education of the People's Republic of China
2021-2024
Harbin Medical University
2024
Second Affiliated Hospital of Harbin Medical University
2024
Cleveland Clinic
2021
Yuncheng University
2019
Shandong University
2011
Pioglitazone (PIO), a thiazolidinediones drug, is well-known anti-diabetic medicine, but its anti-atherosclerotic effects remain controversial. Thus it important to investigate the of PIO on atherogenesis and relevant mechanisms. For in vitro studies, primary cultured or AMP-activated protein kinase (AMPK) inhibited splenocytes were treated with oxidized low density lipoprotein (ox-LDL) ox-LDL plus PIO. Percentage T helper 17 (Th17) regulatory (Treg) cells determined by flow cytometry....
Abstract Myocarditis has emerged as a rare but lethal immune checkpoint inhibitor (ICI)‐associated toxicity. However, the exact mechanism and specific therapeutic targets remain underexplored. In this study, we aim to characterise transcriptomic profiles based on single‐cell RNA sequencing from ICI‐related myocarditis. Peripheral blood mononuclear cell (PBMC) samples were collected four groups for sequencing: (1) patients with newly diagnosed lung squamous carcinoma before treatment (Control...
To quantify and evaluate macular superficial capillaries large vessels separately using an optical coherence tomographic angiography (OCTA)-based automatic segmentation algorithm.In this cross-sectional study, all eyes were scanned OCTA device with 3 × mm cube centered on the fovea. Retinal (arterioles/venules) automatically segmented from vasculature en-face images. All images normalized, binarized, skeletonized for quantification. Metrics of retinal calculated by subtracting measurements...
Aims: COVID-19 patients with comorbidities such as hypertension or heart failure (HF) are associated poor clinical outcomes. The cellular distribution of Angiotensin-converting enzyme 2 (ACE2), the critical for SARS-CoV-2 infection, in human is unknown. We explore underlying mechanism that leads to increased susceptibility cardiovascular diseases and cardiac dysfunction have risk multi-organ injury compared normal function. Methods Results: analyzed single-cell RNA sequencing (scRNA-seq)...
Sleep fragmentation (SF) has been reported to be associated with cardiovascular risk. The aim of this study was explore the relationship between SF and congestive heart failure (CHF).A total 4,887 participants (2,256 males 2,631 females; mean age 63.6 ± 11.0 years) from Heart Health Study were included in study. Incident CHF defined as first occurrence baseline in-home polysomnography (PSG) end follow-up. Objective assessments for SF, including sleep index (SFI), arousal (ArI), efficiency...
While acute myocardial infarction (AMI) is widely recognized as the primary cause of Cardiogenic Shock (CS), Non-AMI related CS has been excluded from majority studies. Information on its prognostic factors remains largely understudied, and it necessary to focus these patients identify specific risk factors. In this study, we aimed build validate a predictive nomogram classification system.
Objective This study aimed to investigate the inhibition of human important phase II metabolic enzyme sulfotransferases (SULTs) by phthalate monoesters, which are metabolites esters (PAEs). Method Recombinant SULT-catalyzed metabolism p-nitrophenol (PNP) was employed as probe reactions SULTs 8 kinds monoesters towards SULT isoforms. An in vitro incubation system utilized for preliminary screening, and 100 μM used. Inhibition kinetics were carried out determine monoesters. Result Multiple...
The inflammatory response after polymer-based drug-eluting stent (DES) placement has recently emerged as a major concern. biologic roles of peroxisome proliferator-activated receptor-γ (PPAR-γ) activators thiazolidinedione (TZD) remain controversial in cardiovascular disease. Herein, we investigated the antiinflammatory effects pioglitazone (PIO) on circulating peripheral blood mononuclear cells (MNCs) patients coronary DES implantation. Methods and Results. Twenty-eight with artery disease...
Abstract Purpose To investigate the semophorin 3A ( SEMA 3A) level in aqueous humor of patients with retinal vein occlusion RVO ) and explore correlation macular oedema ganglion cell degeneration . Methods This comparative study prospectively included 41 consecutive (41 eyes) who had intravitreal anti‐ VEGF injections from March 2014 to 2015 for cystoid CME or neovascular glaucoma NVG ). The were divided into three groups according fluorescein angiograghy FFA ): central CRVO group n = 15),...
There is no definite reperfusion time for inferior ST-elevation myocardial infarction (STEMI) patients presenting later than 12 hours after symptom onset and complicated by newly-developed atrioventricular block (AVB). It not clear whether the percutaneous coronary intervention (PCI) could facilitate recovery of AVB in this patient group. We conducted a retrospective study including 52 consecutive STEMI with >12 new second or third-degree on admission. All them underwent PCI. The clinical...
Background and Objective: To study the drainage pathway using a tracer after modified filtering surgery in rabbit eyes. Materials Methods: The authors performed trabeculectomy combined with deep sclerectomy on one eye (TS group) other (T of 20 rabbits. Cationic ferritin was injected intracamerally just before killing rabbits at postsurgical week 2, 4, 8, 12, or 24. opposite side surgical site used as control. Histologic conducted under light microscopy. Results: In both groups, significantly...
Purpose: Previous research findings on the association between serum total bilirubin (TB) and cardiovascular events varied with different study populations. Our objective was to clarify TB at admission long-term adverse outcomes in patients acute coronary syndrome (ACS) stable angina (SA) undergoing percutaneous intervention (PCI). Patients methods: This prospective cohort included 2,502 who underwent PCI. Information population obtained from Dryad Digital Repository. The were divided into...
The development of cardiogenic shock due to the coexistence Takotsubo cardiomyopathy and thyroid crisis in patients has been scarcely reported.A 46-year-old female presented with chest pain, palpitations, nausea, vomiting for 8 h. She was initially considered have acute myocardial infarction elevated cardiac markers abnormal electrocardiogram changes. Immediately after coronary angiography revealed a normal artery, patient developed refractory shock. Echocardiography demonstrated typical...
Purpose We aim to investigate the risk factors associated with prognosis of proliferative diabetic retinopathy (PDR) after a sequential treatment intravitreal injection bevacizumab (IVB) and pars plana vitrectomy (PPV). Methods In this cohort study, 63 eyes from 55 patients (21 females) diagnosed PDR, who needed PPV for non-clearing vitreous hemorrhage or fibrovascular membrane proliferation were enrolled. All underwent IVB followed by PPV. Anterior chamber tap was performed at beginning...
As one of the commonest diseases, respiratory tract infections (RTIs) are major causes high morbidity and mortality among children, especially recurrent (RRTIs). RRTIs can lead to prolong recovery period, increase cost induce complications. 15-lipoxygenases (15-LOXs) have two isoenzymes: type 1 2 (15-LOX-1, 15-LOX-2), which has been proved be key mediators in inflammatory diseases. In this study, we analyzed expression 15-lipoxygenase isoenzymes cytokines children with RRTIs, determine their...
The patient developed lumbar pain and discomfort 2 years ago due to housework. symptoms were improved after massage treatment at a local clinic, then the above recurred. came Department of Acupuncture Massage Rehabilitation First Affiliated Hospital Shaanxi University Chinese Medicine because "repeated back for years, accompanied by left lower limb aggravated days", was diagnosed as disc herniation. plan mainly electric acupuncture, supplemented traditional medicine hot compress powder....