A5100645486- Cardiac Fibrosis and Remodeling
- Hearing, Cochlea, Tinnitus, Genetics
- Neuroendocrine regulation and behavior
- Tryptophan and brain disorders
- Treatment of Major Depression
- Advanced biosensing and bioanalysis techniques
- Electrochemical sensors and biosensors
- Protease and Inhibitor Mechanisms
- Vestibular and auditory disorders
- Neuroscience and Neuropharmacology Research
- Regulation of Appetite and Obesity
- Gynecological conditions and treatments
- Molecular Sensors and Ion Detection
- Hearing Loss and Rehabilitation
- Ion Transport and Channel Regulation
- Neonatal Respiratory Health Research
- Healthcare Systems and Public Health
- Ocular Surface and Contact Lens
- Health and Wellbeing Research
- Gastrointestinal motility and disorders
- Bioactive natural compounds
- Adipokines, Inflammation, and Metabolic Diseases
- Stress Responses and Cortisol
- Memory and Neural Mechanisms
- Cardiac Imaging and Diagnostics
Nanjing University of Finance and Economics
2025
Henan Academy of Agricultural Sciences
2023-2024
Universidad del Noreste
2023
First Teaching Hospital of Tianjin University of Traditional Chinese Medicine
2021
Soochow University
2019
Leibniz Institute for Neurobiology
2019
University of Tübingen
2019
Otto-von-Guericke University Magdeburg
2018
Tianjin University of Traditional Chinese Medicine
2015-2017
Institute of Agro-Products Processing Science and Technology
2017
Objectives Synaptic plasticity and brain-derived neurotrophic factor (BDNF) signalling are proposed to play key roles in antidepressant drug action. Ketamine, an N-methyl-D-aspartate receptor antagonist putative antidepressant, may increase synaptic prefrontal cortex through higher expression of BDNF. Furthermore, ketamine was shown change resting-state functional connectivity (RSFC) dorsomedial (dmPFC).Methods In a randomised, placebo-controlled study, we investigated acutely (100 min) at...
Pyridaben, a broad-spectrum pyridazinone acaricide that is widely used in agricultural production, can induce neurotoxicity and reproductive abnormalities, highly toxic to aquatic organisms. In this study, pyridaben hapten was synthesized prepare monoclonal antibodies (mAbs), among which 6E3G8D7 showed the highest sensitivity indirect competitive enzyme-linked immunosorbent assay, with 50% inhibitory concentration (IC50) of 3.49 ng mL-1. The mAb, 6E3G8D7, further applied gold...
Abstract Functional dyspepsia is a common functional gastrointestinal disorder. Gastric hypersensitivity (GHS) hallmark of this disorder, but the cellular mechanisms remain largely unknown. Stressors during gestational period could have effects on offspring's tissue structure and function, which may predispose to diseases. The aim study was test whether prenatal maternal stress (PMS) induces GHS investigate role acid-sensing ion channel (ASIC)/nuclear factor-κB (NF-κB) signaling by examining...
This study investigated the effect of QiShenYiQi pill (QSYQ) on myocardial collagen metabolism in rats with partial abdominal aortic coarctation and explored its mechanism action. A series assays were used to detect QSYQ systolic blood pressure, heart mass index, left ventricle HYP, expression PICP, PIIINT, CTX-I serum, MMP-1, TIMP-1 myocardium. We observed that can reduce rate synthesis increase degradation. It also effectively improved degree fibrosis it had a tendency have greater longer...
Onset delay of current antidepressants is always the most significant limitation for treatment depression. More attention has been given to glutamate acid system developing fast-onset antidepressants. Xenon, acting as a well-known N-methyl-D-aspartate receptors antagonist, widely used clinically anesthetics and was reported exert antidepressant-like effects in rats under normal condition. The robust rapid-acting antidepressant- anxiolytic-like activities xenon through use depression rodent...
1. Akoh C.C., Min D.B., Food Lipids: Chemistry, Nutrition and Biotechnology. 2008. Lipid Oxidation of Muscle Food, Third edn. CRC Press, Taylor Francis Group, pp. 322-347. Google Scholar
To study the efficacy and safety of Jiang Tang Fang Long Jiao Nang (Hypoglycemic Anti–Deafness Capsule) in treating non–insulin dependent diabetes mellitus with hearing loss. Two hundred ninety six patients loss were randomly assigned to a treatment group(n=164, 208 ears) control group(n=132, 184 ears). Patients group treated supplement herbal preparations as indicated by traditional Chinese medicine dialectical assessment, while received glibenclamide conventional treatments for deafness....
Through experiment on animals and clinical trials to explore the safety efficacy of hypoglycemic anti-deafness capsules diabetic patients with deafness. Total 296 non-insulin dependent diabetes mellitus (NIDDM) were randomly divided into two groups. A treatment group 164 (208 ears) was treated based TCM syndrome differentiation. control 132 (184 glibenclamide conventional drug for The following observed: hearing, fasting plasma glucose (FPG), 2 h postprandial (2hPG), 24 urine (24hUG),...
For efficient intranasal transport of parathyroid hormone (1-34) [PTH(1-34)], there is a great medical need to investigate permeation enhancers for formulations. In this study, the development PTH(1-34) formulations was conducted. Based on conformation and chemical stability studies, most preferable aqueous environment determined be 0.008 M acetate buffer solution (ABS). Subsequently, citric acid Kolliphor® HS·15 were compared as enhancers. The mechanisms action investigated using an in...
Pressure-overloaded myocardial hypertrophy is an independent risk factor for various cardiovascular diseases (CVDs), such as heart failure (HF), arrhythmia, and even sudden death. It reported that QiShenYiQi pill (QSYQ) widely used in the treatment of CVDs can prevent pathological myocardium, but its specific mechanism still unclear. In this study, a rat model was established through pressure overload caused by abdominal aortic constriction Wistar rats. The rats were randomly divided into...
To study the influence of Jiang Tang Fang Long formula on insulin production and function in an animal model diabetic hearing loss. Wistar rats (n=60) were randomly divided into 6 groups (10 each) to receive no treatment (the normal control, Group A), or intra-peritoneal 55 mg/kg streptozotocin with (Groups C, D E) without (Group B) subsequent at various doses Yu Wan F). After 60 days, fasting blood glucose (FBG), body weight (BW) (FINS) recorded HOMA-IR HOMA-β calculated. Insulin expression...
Objective To investigate the clinical effect of active immunotherapy combined with endometrial local injury in women recurrent spontaneous abortion(RSA) caused by negative-blocking antibodies. Methods 112 patients diagnosed RSA antibodies were randomly divided into treatment group (62 patients)and control group(50 patients).The treated injury.The immunotherapy.The pregnancy outcomes observed. Results The rate was 93.54% group,and 80.00% group.The success significant higher than...
In this article, meso-scale simulations and modelling on the multi-layer spreading printing of tungsten (W) through electron beam powder bed fusion (EB-PBF) were conducted by three-dimensional discrete element method (DEM) coupled computational fluid dynamics (CFD) approach, in which recurring pore defects explored, cooperative effects parameters during (spreading velocity Vs, direction) (melting power Pm, melting Vm) formation end melted area analyzed. Based simulation repetitive...
To study effects of Jiangtang Fanglong Wan (glucose–lowering and deafness–preventing capsule) on hearing in an animal model diabetes. Wistar rats were used to create a diabetes by intraperitoneal injection streptozotocin (STZ, 55 mg/kg). Forty randomly selected receive (10 g/kg/day) through intragastric gavage (treatment group) or normal saline (control group). Auditory brainstem responses (ABRs) recorded at Months 1, 2 3. ABR latencies wave intervals similar between the two groups Month 1...