A5026964915- Functional Brain Connectivity Studies
- Treatment of Major Depression
- Neural dynamics and brain function
- Tryptophan and brain disorders
- Neuroscience and Neuropharmacology Research
- Advanced MRI Techniques and Applications
- EEG and Brain-Computer Interfaces
- melanin and skin pigmentation
- Stress Responses and Cortisol
- Advanced Neuroimaging Techniques and Applications
- Saffron Plant Research Studies
- Electrochemical Analysis and Applications
- Computational Drug Discovery Methods
- Neural and Behavioral Psychology Studies
- Nicotinic Acetylcholine Receptors Study
- Mental Health Research Topics
- Neurotransmitter Receptor Influence on Behavior
- Diet and metabolism studies
- Barrier Structure and Function Studies
Jena University Hospital
2020-2025
University Hospital Magdeburg
2017-2024
Medical University of Vienna
2022
Friedrich Schiller University Jena
2022
Leibniz Institute for Neurobiology
2017-2022
Otto-von-Guericke University Magdeburg
2018-2020
University Children's Hospital Tübingen
2017-2018
Schott (Germany)
2017
University of Tübingen
2017
QIMR Berghofer Medical Research Institute
2017
Objectives Synaptic plasticity and brain-derived neurotrophic factor (BDNF) signalling are proposed to play key roles in antidepressant drug action. Ketamine, an N-methyl-D-aspartate receptor antagonist putative antidepressant, may increase synaptic prefrontal cortex through higher expression of BDNF. Furthermore, ketamine was shown change resting-state functional connectivity (RSFC) dorsomedial (dmPFC).Methods In a randomised, placebo-controlled study, we investigated acutely (100 min) at...
The increasing use of ketamine as a potential rapid-onset antidepressant necessitates better understanding its effects on blood pressure and heart rate, well-known side at higher doses. For the subanesthetic dose used for depression, predictors these cardiovascular are important factors influencing clinical decisions. Since influences sympathetic nervous system, we investigated impact autonomic system-related response: genetic polymorphism in norepinephrine transporter gender effects.Blood...
Abstract The locus coeruleus (LC) is involved in numerous crucial brain functions and several disorders like depression Alzheimer's disease. Recently, the LC resting‐state functional connectivity (rs‐fc) has been investigated MRI by calculating blood oxygen level–dependent (BOLD) response extracted using Montreal Neurological Institute (MNI) space masks. To corroborate these results, we aimed to investigate rs‐fc at native improving identification of location a neuromelanin sensitive...
Abstract Dysfunctions in bottom‐up emotion processing (EP), as well top‐down regulation (ER) are prominent features pathophysiology of major depressive disorder (MDD). Nonetheless, it is not clear whether EP‐ and ER‐related areas regionally and/or connectively disturbed MDD. In addition, yet to be known how interactively linked regulatory behavior, this interaction disrupted our study, regional amplitude low frequency fluctuations (ALFF) whole‐brain functional connectivity (FC)...
Abstract The locus coeruleus (LC) in the brainstem as main regulator of brain noradrenaline gains increasing attention because its involvement neurologic and psychiatric diseases relevance general to function. In this study, we created a structural connectome LC nerve fibers based on vivo MRI tractography gain an understanding into connectivity impact LC-related psychological measures. We combined our results with ultra-high field resting-state functional learn about relationship between...
Abstract Sleep onset is characterized by a departure from arousal, and can be separated into well-differentiated stages: NREM (which encompasses three substages: N1, N2 N3) REM (Rapid Eye Movement). Awake brain dynamics are maintained various wake-promoting mechanisms, particularly the neuromodulators Acetylcholine (ACh) Noradrenaline (NA), whose levels naturally decrease during transition to sleep. The combined influence of these neurotransmitters on connectivity sleep remains unclear, as...
Ketamine is receiving increasing attention as a rapid-onset antidepressant in patients suffering from major depressive disorder (MDD) with treatment resistance or severe suicidal ideation. modulates several neurotransmitter systems, including norepinephrine via the transporter (NET), both peripherally and centrally. The locus coeruleus (LC), which has high NET concentration, been attributed to brain networks involved depression. Thus we investigated effects of single-dose racemic ketamine on...
Dementia as one of the most prevalent diseases urges for a better understanding central mechanisms responsible clinical symptoms, and necessitates improvement actual diagnostic capabilities. The brainstem nucleus locus coeruleus (LC) is promising target early diagnosis because its structural alterations relationship to functional disturbances in patients. In this study, we applied our improved method localisation-based LC resting-state fMRI investigate differences sensory signal processing...
Abstract Ketamine shows rapid antidepressant effects peaking 24 h after administration. The may occur through changes in glutamatergic metabolite levels and resting-state functional connectivity (rsFC) within the default mode network (DMN). A multistage drug effect of ketamine has been suggested, inducing acute on dysfunctional configuration delayed homeostatic synaptic plasticity. Whether DMN-centered antidepressant-related are associated with immediate remains unknown. Thirty-five healthy...
Brain investigations identified salience network (SN) comprising the dorsal Anterior Cingulate Cortex (dACC) and Insula (AI). Magnetic resonance spectroscopy (MRS) studies revealed link between glutamate concentration in ACC alterations attentional scope. Hence, we investigated whether dACC modulates brain response during processing.Twenty-seven healthy subjects (12♀, 15♁) provided both STEAM MRS at 7T measuring concentrations as well a functional magnetic imaging (fMRI) task to study...
We describe a collection of T1-, diffusion- and functional T2*-weighted magnetic resonance imaging data from human individuals with albinism achiasma. This repository can be used as test-bed to develop validate tractography methods like diffusion-signal modeling fiber tracking well investigate the properties visual system in congenital abnormalities. The MRI is provided together tools files allowing for its preprocessing analysis, along derivatives such manually curated masks regions...
Dysfunctions in bottom-up emotion processing (EP), as well top-down regulation (ER) are prominent features pathophysiology of major depressive disorder (MDD). Nonetheless, it is not clear whether EP- and ER-related areas regionally and/or connectively disturbed, how they interactively linked to abnormal affective symptoms MDD. In this study, regional amplitude low frequency fluctuations (ALFF) whole-brain functional connectivity (FC) meta-analytic-driven seeds were compared between 20 MDD...
The NMDA antagonist S-ketamine is gaining increasing use as a rapid-acting antidepressant, although its exact mechanisms of action are still unknown. In this study, we investigated ketamine in respect to properties toward central noradrenergic and how they influence alertness behavior.
The human optic chiasm is formed normally by almost equal populations of crossing and non-crossing nerve fibers. This proportion can be affected rare disorders, such as albinism or achiasma (Hoffmann Dumoulin, 2015), causing, respectively, over- under-representation In the light recent studies revealing those differences from anatomical measures (Puzniak et al., 2019), appears a valuable model for researchers interested in impacts deficits vision on brain white matter tractography methods...