A5068649838- Treatment of Major Depression
- Functional Brain Connectivity Studies
- Tryptophan and brain disorders
- Neural dynamics and brain function
- Stress Responses and Cortisol
- Mental Health Research Topics
- Heart Rate Variability and Autonomic Control
- Diet and metabolism studies
- Psychedelics and Drug Studies
- Neural and Behavioral Psychology Studies
- EEG and Brain-Computer Interfaces
- Advanced MRI Techniques and Applications
- Gut microbiota and health
- Pain Management and Placebo Effect
- Neuroinflammation and Neurodegeneration Mechanisms
- Nicotinic Acetylcholine Receptors Study
- Spaceflight effects on biology
- Pain Mechanisms and Treatments
- Neuroscience and Neuropharmacology Research
- Anesthesia and Neurotoxicity Research
- Pharmacological Effects of Natural Compounds
- Analytical Chemistry and Chromatography
- Circadian rhythm and melatonin
- Traumatic Brain Injury and Neurovascular Disturbances
- Medicinal Plants and Bioactive Compounds
University of Tübingen
2020-2024
Leibniz Institute for Neurobiology
2019-2024
Jena University Hospital
2020-2024
Friedrich Schiller University Jena
2024
Trinity College Dublin
2024
Klinik und Poliklinik für Psychiatrie und Psychotherapie
2022
University Hospital Magdeburg
2019
Electroencephalogram (EEG) microstates that represent quasi-stable, global neuronal activity are considered as the building blocks of brain dynamics. Therefore, analysis microstate sequences is a promising approach to understand fast dynamics underlie various mental processes. Recent studies suggest EEG non-Markovian and nonstationary, highlighting importance sequential flow information between different states. These findings inspired us model these using Recurrent Neural Networks (RNNs)...
The brain continuously receives input from the internal and external environment. Using this information, exerts its influence on both itself body to facilitate an appropriate response. dynamic interplay between heart how conditions modulate relationship deserves attention. Presumably, in high-stress situations synchrony various regions such as prefrontal cortex may alter. This flexibility is believed transitions functional states related cognitive, emotional and, especially, autonomic...
Social stress contributes to major societal health burdens, such as anxiety disorders and nervousness. Nx4 has been found modulate responses. We investigated whether dampening of responses is associated with neuronal correlates in brain regions involved anxiety. In a randomized, placebo-controlled, double-blind, cross-over trial, 39 healthy males took single dose (three tablets) either placebo or Nx4, 40 60 minutes before an fMRI scan session. here report on drug effects amygdala during...
Abstract Ketamine is a dissociative anesthetic that induces shift in global consciousness states and related brain dynamics. Portable low-density EEG systems could be used to monitor these effects. However, previous evidence almost null lacks adequate methods address dynamics with small number of electrodes. This study delves into high-order interactions (HOI) explore the effects ketamine using portable EEG. In double-blinded cross-over design, 30 male adults (mean age = 25.57, SD 3.74) were...
Recent advances have enabled the creation of wireless, "dry" electroencephalography (EEG) recording systems, and easy-to-use engaging tasks, that can be operated repeatedly by naïve users, unsupervised in home. Here, we evaluated validity dry-EEG, cognitive task gamification, home-based recordings used combination. Two separate cohorts participants-older younger adults-collected data at home over several weeks using a wireless dry EEG system interfaced with tablet for presentation. Older...
Abstract Reproducible resting‐state functional connectivity (rsFC) patterns and their alterations play an increasing role in neuropsychiatric research. Studies that limit the analysis of metabolites rsFC strengths to a predefined canonical network suggest strength positively correlates with local glutamate (Glu) levels negatively gamma‐aminobutyric acid (GABA) levels. The contribution regional neurotransmitter activity from given seed whole‐brain remains unclear. In this study, 121 healthy...
Subanesthetic doses of ketamine induce an antidepressant effect within hours in individuals with treatment-resistant depression while it furthermore induces immediate but transient psychotomimetic effects. Among these effects, altered sense self has specifically been associated the response to as well psychedelics. However, there is plenty variation extent drug-induced experience that might be explained by differences basal morphological characteristics, such cortical thickness. Regions have...
Abstract Ketamine shows rapid antidepressant effects peaking 24 h after administration. The may occur through changes in glutamatergic metabolite levels and resting-state functional connectivity (rsFC) within the default mode network (DMN). A multistage drug effect of ketamine has been suggested, inducing acute on dysfunctional configuration delayed homeostatic synaptic plasticity. Whether DMN-centered antidepressant-related are associated with immediate remains unknown. Thirty-five healthy...
Background: The basic functional organization of the resting brain, assessed as resting-state connectivity (rsFC), can be affected by previous stress experience and it represents basis on which subsequent develops. Notably, rsFC between amygdala cortical regions associated with emotion regulation anxiety are during stress. multicomponent drug Neurexan® (Nx4) has previously demonstrated a reduction in activation an emotional face matching task ameliorated stress-related symptoms. We, thus,...
Along with its rapid therapeutic benefits, ketamine induces transient experience of dissociation during administration. Given the suggested association between ketamine-induced and treatment response, understanding neural correlates would help to elucidate mechanism. The posteromedial cortex (PMC) has been reported play a vital role in induced by psychedelics. In this study, we investigated whether pleasant unpleasant dissociations can be predicted PMC functional connectivity (FC) profile...
<title>Abstract</title> Methods In a double-blinded cross-over design, 30 adults (mean age = 25.57, SD 3.74; all male) were administered racemic ketamine and compared against saline infusion as control. Both task-driven (auditory oddball paradigm) resting-state EEG recorded. HOI computed using advanced multivariate information theory tools, allowing us to quantify nonlinear statistical dependencies between possible electrode combinations. Results: Ketamine increased redundancy in brain...
The NMDA antagonist S-ketamine is gaining increasing use as a rapid-acting antidepressant, although its exact mechanisms of action are still unknown. In this study, we investigated ketamine in respect to properties toward central noradrenergic and how they influence alertness behavior.
Subanesthetic doses of ketamine induce an antidepressant effect within hours in individuals with treatment-resistant depression while it furthermore induces immediate but transient psychotomimetic effects. Among these effects, altered sense self has specifically been associated the response to as well psychedelics. However, there is plenty variation extent drug-induced experience that might be explained by differences basal morphological characteristics, such cortical thickness. Regions have...
Ketamine is a rapid-acting antidepressant that also influences neural reactivity to affective stimuli. However, the effect of ketamine on behavioral yet be elucidated. The affect-modulated startle reflex paradigm (AMSR) allows examining valence-specific aspects reactivity. We hypothesized alters modulation during processing unpleasant and pleasant stimuli weakens resting-state functional connectivity (rsFC) within modulatory pathway, namely between centromedial nucleus amygdala reticularis...
Event Abstract Back to Effects of Neurexan® on emotional brain response Lena Danyeli1, 2, 3*, Luisa Fensky2, 3, Vanessa Teckentrup2, Anne Kühnel2, Myron Schultz4, Yan Fan2, 5 and Martin Walter2, 3 1 Otto-von-Guericke University Magdeburg, Department for Psychiatry Psychotherapy, Germany 2 Clinical Affective Neuroimaging Laboratory, Eberhard Karls Tübingen, 4 Biologische Heilmittel Heel GmbH, Psychiatry, CBF, Charité, Introduction: Neurexan®, a natural pharmaceutical product sold over the...
Event Abstract Back to Effects of Neurexan® on brain responses deviant stimuli during an auditory oddball task Lena Danyeli1, 2, 3*, Sarah Alizadeh3, Galina Surova2, Hamidreza Jamalabadi3, Myron Schultz4 and Martin Walter2, 3 1 Otto-von-Guericke University Magdeburg, Department Psychiatry Psychotherapy, Germany 2 Clinical Affective Neuroimaging Laboratory, Eberhard Karls Tübingen, for 4 Biologische Heilmittel Heel GmbH, Introduction: Neurexan®, a medicinal product sold over the counter...