A5021135343- Neuroscience and Neuropharmacology Research
- Neurotransmitter Receptor Influence on Behavior
- Neural dynamics and brain function
- Memory and Neural Mechanisms
- Receptor Mechanisms and Signaling
- Functional Brain Connectivity Studies
- Tryptophan and brain disorders
- Neuroendocrine regulation and behavior
- Stress Responses and Cortisol
- Ion channel regulation and function
- Neurological disorders and treatments
- Treatment of Major Depression
- Neuroinflammation and Neurodegeneration Mechanisms
- Neural and Behavioral Psychology Studies
- Genetics and Neurodevelopmental Disorders
- Schizophrenia research and treatment
- Diet and metabolism studies
- Advanced Neuroimaging Techniques and Applications
- Animal testing and alternatives
- Neuroscience and Neural Engineering
- Genetic Associations and Epidemiology
- EEG and Brain-Computer Interfaces
- Autism Spectrum Disorder Research
- Phosphodiesterase function and regulation
- Neuroscience and Music Perception
Takeda (United States)
2017-2024
McLean Hospital
2024
Harvard University
2021-2024
Sage Therapeutics (United States)
2023-2024
Jena University Hospital
2024
Alto Neuroscience (United States)
2024
Trinity College Dublin
2024
Takeda (Japan)
2022-2023
University of Maryland, Baltimore
2009-2021
Pfizer (United States)
2013-2020
The interactions among excitatory inputs arising from the prefrontal cortex, amygdala, and hippocampus, innervating nucleus accumbens neurons were studied using in vivo intracellular recording techniques. Neurons recorded displayed one of three activity states: (1) silent, (2) spontaneously firing at low, constant rates, or (3) a bistable membrane potential, characterized by alternating periods silence occurring concert with spontaneous transitions between two steady-state potentials...
The regional distribution of white matter (WM) abnormalities in schizophrenia remains poorly understood, and reported disease effects on the brain vary widely between studies. In an effort to identify commonalities across studies, we perform what believe is first ever large-scale coordinated study WM microstructural differences schizophrenia. Our analysis consisted 2359 healthy controls 1963 patients from 29 independent international studies; harmonized processing statistical analyses...
Although the importance of dopamine (DA) for prefrontal cortical (PFC) cognitive functions is widely recognized, nature DA actions in PFC remains controversial. A critical component its modulation glutamate transmission, which can be different when specific receptors are activated. To obtain a clear picture cellular mechanisms involved these interactions, we studied effects DA–glutamate coactivation on pyramidal cell excitability brain slices obtained from developmentally mature rats using...
Adolescence is marked by profound psychological and neuroendocrine changes. Cognitive functions that depend on the prefrontal cortex dopamine (DA), such as decision making, are acquired or refined during adolescence; yet, little known about how neural circuits mature in transition to adulthood. Here, we conducted electrophysiological recordings rat brain slices, unveiling an enhancement of excitability interneurons, which important for cortical network activity, D(1) D(2) DA receptors. The...
Parvalbumin inhibitory interneurons (PVIs) are crucial for maintaining proper excitatory/inhibitory balance and high-frequency neuronal synchronization. Their activity supports critical developmental trajectories, sensory cognitive processing, social behavior. Despite heterogeneity in the etiology across schizophrenia autism spectrum disorder, PVI circuits altered these psychiatric disorders. Identifying mechanism(s) underlying deficits is essential to establish treatments targeting...
Several psychiatric disorders are associated with white matter defects, suggesting that oligodendrocyte (OL) abnormalities underlie some aspects of these diseases. Neuregulin 1 (NRG1) and its receptor, erbB4, genetically linked susceptibility to schizophrenia bipolar disorder. In vitro studies suggest NRG1-erbB signaling is important for OL development. To test whether erbB contributes by regulating the structure or function OLs, we analyzed transgenic mice in which blocked OLs vivo. Here...
Abstract Digital health technologies can provide continuous monitoring and objective, real-world measures of Parkinson’s disease (PD), but have primarily been evaluated in small, single-site studies. In this 12-month, multicenter observational study, we whether a smartwatch smartphone application could measure features early PD. 82 individuals with early, untreated PD 50 age-matched controls wore research-grade sensors, smartwatch, while performing standardized assessments the clinic. At...
In vivo, cortical neurons and striatal medium spiny (MSN) display robust subthreshold depolarizations (Up states) during which they are enabled to fire action potentials. the cortex, Up states believed occur simultaneously in a neuronal ensemble be sustained by local network interactions. It is known that MSN impelled into state extra-striatal (primarily cortical) inputs, but mechanisms sustain determine end of still debated. Furthermore, it has not been established if brisk perturbations...
We describe a computational model of the principal cell in nucleus accumbens (NAcb), medium spiny projection (MSP) neuron. The neuron, constructed NEURON, includes all known ionic currents these cells and receives synaptic input from simulated spike trains via NMDA, AMPA, GABA A receptors. After tuning by adjusting maximal current conductances each compartment, closely matched whole-cell recordings an adult rat NAcb slice preparation. Synaptic inputs range 1000-1300 Hz are required to...
The prefrontal cortex (PFC) is critical for decision making, and it becomes dysfunctional in many neuropsychiatric disorders. Studies schizophrenia patients relevant animal models suggest loss of PFC inhibitory interneuron function. For instance, rats with a neonatal ventral hippocampal lesion (NVHL) show deficient modulation interneurons by dopamine (DA). Whether the disinhibited this model alters making remains to be determined. Here, we recorded neural activity medial NVHL during...
Animals with a neonatal ventral hippocampal lesion (NVHL) develop abnormal behaviors during or after adolescence, suggesting that early insults can have delayed consequences. Many of these depend on the prefrontal cortex (PFC), and we reported PFC pyramidal neurons adult rats an NVHL respond to stimulation tegmental area increase in firing instead characteristic decrease. As dopamine modulation cortical interneurons matures findings raise possibility maturation local inhibitory circuits...