A5012893465- Functional Brain Connectivity Studies
- Neurotransmitter Receptor Influence on Behavior
- Neuroscience and Neuropharmacology Research
- Neural dynamics and brain function
- Psychedelics and Drug Studies
- Treatment of Major Depression
- Tryptophan and brain disorders
- Transcranial Magnetic Stimulation Studies
- Neural and Behavioral Psychology Studies
- Obsessive-Compulsive Spectrum Disorders
- Advanced Neuroimaging Techniques and Applications
- Cleft Lip and Palate Research
- EEG and Brain-Computer Interfaces
- Schizophrenia research and treatment
- Mental Health Research Topics
- Cytomegalovirus and herpesvirus research
- Stress Responses and Cortisol
- Toxoplasma gondii Research Studies
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Atomic and Molecular Physics
- Neuroendocrine regulation and behavior
- Receptor Mechanisms and Signaling
- Congenital Anomalies and Fetal Surgery
- Prenatal Screening and Diagnostics
- Bipolar Disorder and Treatment
Charles University
2016-2025
National Institute of Mental Health
2016-2025
National Institute of Mental Health
2019-2024
National Institute of Public Health
2021
Národní Ústav pro Vzdělávání
2021
Czech Academy of Sciences, Institute of Psychology
2020
University Hospital in Motol
2020
Gennet
2012-2019
Czech Academy of Sciences, J. Heyrovský Institute of Physical Chemistry
2018
Thomayer University Hospital
2008-2015
The regional distribution of white matter (WM) abnormalities in schizophrenia remains poorly understood, and reported disease effects on the brain vary widely between studies. In an effort to identify commonalities across studies, we perform what believe is first ever large-scale coordinated study WM microstructural differences schizophrenia. Our analysis consisted 2359 healthy controls 1963 patients from 29 independent international studies; harmonized processing statistical analyses...
Schizophrenia is a complex neuropsychiatric disorder with variable symptomatology, traditionally divided into positive and negative symptoms, cognitive deficits. However, the etiology of this has yet to be fully understood. Recent findings suggest that alteration basic sense self-awareness may an essential distortion schizophrenia spectrum disorders. In addition, extensive research social mentalizing abilities stressed role skills in schizophrenia.This article aims propose support concept...
Addressing global mental health is a major 21st-century challenge. Current treatments have recognized limitations; in this context, new ones that are prophylactic and effective across diagnostic boundaries would represent advance. The view there exists core of transdiagnostic overlap between psychiatric disorders has re-emerged recent years, evidence psychedelic therapy holds promise for range supports the position it may be transdiagnostically effective. Here, we propose therapy's core,...
<i>Background:</i> Auditory hallucinations are characteristic symptoms of schizophrenia with high clinical importance. It was repeatedly reported that low frequency (≤1Hz) repetitive transcranial magnetic stimulation (rTMS) diminishes treatment-resistant auditory hallucinations. A neuroimaging study elucidating the effect rTMS in has yet to be published. <i>Objective:</i> To evaluate distribution neuronal electrical activity and brain metabolism changes after...
Objectives. To address the role of latent T. gondii infection in schizophrenia we studied influence toxoplasmosis on brain morphology. Methods. An optimized voxel-based morphometry magnetic resonance imaging was analyzed by analysis variance with diagnosis and seropositivity as factors 44 schizophrenic patients (12 positive) 56 controls (13 positive). Results. Grey matter (GM) volume reduced compared cortical regions, hippocampus caudate. In sample found a significant reduction GM positive...
<i>Aims:</i> This study was designed to evaluate the changes in EEG power spectra and coherence a ketamine model of psychosis rats. Analyses behavioral measurements – locomotion sensorimotor gating pharmacokinetics norketamine were also conducted. <i>Methods:</i> Ketamine levels rat sera brains analyzed by gas chromatography-mass spectrometry after 30 mg/kg (i.p.). 9 (i.p.) used experiments. Locomotor effects an open field test deficits prepulse inhibition acoustic...
Objective Toxoplasmosis is a lifelong parasitic disease that appears to be associated schizophrenia. However, no distinguishing attributes in T oxoplasma‐ infected schizophrenia patients have been described as yet. Method We searched for differences symptom profile, cognitive performance and treatment response between 194 oxoplasma ‐free 57 (22.7%) ‐infected treated P rague sychiatric C entre 2000 2010. Results Infected non‐infected differed severity of symptoms ( = 0.032) measured with the...
Latent toxoplasmosis, the life-long presence of dormant stages Toxoplasma in immunoprivileged organs and anamnestic IgG antibodies blood, affects about 30% humans. Infected subjects have an increased incidence various disorders, including schizophrenia. Several studies, as well character toxoplasmosis-associated disturbance neurotransmitters, suggest that toxoplasmosis could also play etiological role Obsessive-Compulsive Disorder (OCD).The aim present cross-sectional study performed on a...
Infection by the parasite Toxoplasma, which affects about 33% of world population, is associated with an increased risk several mental health disorders, most strongly schizophrenia. It unknown whether schizophrenia this infection strongly, or association has just been intensively studied for historical reasons. We used data from 6,367 subjects tested toxoplasmosis who took part in internet survey to search associations these infections 24 disorders and evidence otherwise impaired health. The...
Abstract The human brain represents a complex computational system, the function and structure of which may be measured using various neuroimaging techniques focusing on separate properties tissue activity. We capture organization white matter fibers acquired by diffusion-weighted imaging probabilistic diffusion tractography. By segmenting results tractography into larger anatomical units, it is possible to draw inferences about structural relationships between these parts system. This...
The open field test (OFT) is a basic and most widely used for investigation in animal studies of the neurobiological basis anxiety screening novel drug targets. Here, we present results an OFT weakly electric fish Gnathonemus petersii. This study aimed to describe behavioral response G. petersii exposed OFT, simultaneously with evaluation electrical organ discharges (EOD), determine whether any association between EOD patterns motor behavior exists. Treatment activity its temporal patterning...
Psilocybin has recently attracted a great deal of attention as clinical research and therapeutic tool. The aim this paper is to bridge two major knowledge gaps regarding its behavioural pharmacology - sex differences the underlying receptor mechanisms. We used psilocin (0.25, 1 4 mg/kg), an active metabolite psilocybin, in paradigms open-field test prepulse inhibition (PPI) acoustic startle reaction. Sex were evaluated with respect phase female cycle. contribution serotonin receptors action...