A5003473401- Memory and Neural Mechanisms
- Neuroscience and Neuropharmacology Research
- Olfactory and Sensory Function Studies
- Zebrafish Biomedical Research Applications
- Spatial Cognition and Navigation
- Child and Animal Learning Development
- Psychological and Temporal Perspectives Research
- Lipoproteins and Cardiovascular Health
- Visual perception and processing mechanisms
- Neural dynamics and brain function
- Face Recognition and Perception
- Cognitive Abilities and Testing
- Neuroscience and Music Perception
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cognitive and developmental aspects of mathematical skills
- Tryptophan and brain disorders
- Stress Responses and Cortisol
- Action Observation and Synchronization
- Multisensory perception and integration
- Neural and Behavioral Psychology Studies
- Functional Brain Connectivity Studies
- Blood Pressure and Hypertension Studies
- Pharmacological Receptor Mechanisms and Effects
- Creativity in Education and Neuroscience
- Psychology of Moral and Emotional Judgment
National Institute of Mental Health
2016-2022
Charles University
2008-2022
Czech University of Life Sciences Prague
2019-2022
Czech Academy of Sciences
2006-2021
Czech Academy of Sciences, Institute of Physiology
2008-2021
National Institute of Public Health
2020
General University Hospital in Prague
2016
Schizophrenia is a complex neuropsychiatric disorder with variable symptomatology, traditionally divided into positive and negative symptoms, cognitive deficits. However, the etiology of this has yet to be fully understood. Recent findings suggest that alteration basic sense self-awareness may an essential distortion schizophrenia spectrum disorders. In addition, extensive research social mentalizing abilities stressed role skills in schizophrenia.This article aims propose support concept...
Neither pain, nor depression exist as independent phenomena per se, they are highly subjective inner states, formed by our brain and built on the bases of experiences, cognition emotions. Chronic pain is associated with changes in physiology anatomy. It has been suggested that neuronal activity underlying perception chronic may be divergent from acute pain. We will discuss possible common pathophysiological mechanism respect to default mode network brain, neuroplasticity effect...
Abstract Stable inter-individual differences in behaviour and personality have been studied for several decades now. The aim of this study was to test the repeatability Long Evans strain laboratory rats order assess their differences. Male (n = 36) were tested a series tasks (Open field test, Elevated plus maze modified T-maze test) repeated over time traits. To evaluate temporal stability behaviour, we calculated estimates examined We also checked link behavioural traits across these...
A number of studies demonstrated a rapid onset an antidepressant effect non-competitive N-methyl-d-aspartic acid receptor (NMDAR) antagonists. Nonetheless, its therapeutic potential is rather limited, due to high coincidence negative side-effects. Therefore, the challenge seems be in development NMDAR antagonists displaying properties, and at same time maintaining regular physiological function NMDAR. Previous results that naturally occurring neurosteroid 3α5β-pregnanolone sulfate shows...
3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors (statins) are widely used drugs for lowering blood lipid levels and preventing cardiovascular diseases. However, statins can have serious adverse effects, which may be related to development of mitochondrial dysfunctions. The aim study was demonstrate the in vivo effect high therapeutic doses on respiration platelets. Model approach study. Simvastatin administered rats at a dose 4 weeks. Humans were treated with...
Bilateral intratympanic sodium arsenate injections (100 mg/ml in isotonic saline) adult male Long Evans rats produced impairments allocentric navigation using a 12-arm radial maze procedure as well motor test battery designed to evaluate vestibular function. In contrast, no the accuracy or precision of duration reproduction 20-s and 80-s peak-interval procedures were observed when both target durations associated with same lever response, but distinguished by signal modality (e.g., light...
Human perception and cognition are based predominantly on visual information processing. Much of the regarding neuronal correlates processing has been derived from functional imaging studies, which have identified a variety brain areas contributing to analysis, recognition objects scenes. However, only two these areas, namely parahippocampal place area lateral occipital complex, were verified further characterized by intracranial electroencephalogram (iEEG). iEEG is unique measurement...
Abstract Rat hippocampus plays a crucial role in many spatial tasks, including recognition of position objects, which can be approached and explored. Whether is also necessary for recognizing positions objects located an inaccessible part the environment remains unclear. To address this question, we conditioned rats to press lever when object displayed on distant computer screen was particular (“reward position”) not other (“nonreward positions”). After had reached asymptotic performance,...
We developed a novel behavioral task in which rats learn to recognize the configuration of objects an animated scene displayed on computer screen. The consisted moving bar and stationary rectangle. Rats deprived food were trained press lever for reward small chamber located front Lever presses rewarded only when was at anticipated by gradually increasing frequency pressing as approached Control experiments showed that neither timing nor discrimination non-rewarded periods two discrete...
Background . Augmented reality (AR) glasses with GPS navigation represent the rapidly evolving technology which spares (and externalizes) navigational capacities. Regarding expected everyday usage of this device, its impact on neuroplastic brain changes and abilities should be evaluated. Aims This study aimed to assess possible in functional connectivity (FC) hippocampus other regions involved spatial navigation. Methods Thirty-three healthy participants completed two resting state magnetic...
Standard cognitive measures are often applied at various times of the day to assess deficits in patients with neuropsychiatric and neurodegenerative disorders, irrespective their chronotype. In this study, we aimed determine whether subjectively nonpreferred time an assessment might be a crucial factor persons extreme chronotypes. We compared morning (08:00) evening (20:00) performance morning, evening, intermediate chronotypes determined by Morningness-Eveningness Questionnaire, supported...
This study analyzes how people's attitudes to the European refugee crisis (ERC) correspond selected psychological state and trait measures impact neural processing of media images refugees. From a large pool respondents, who filled in an online xenophobia questionnaire, we two groups (total N = 38) with same socio-demographic background, but opposite toward We found that negative attitude refugees (high - HX) was associated significantly higher conscientiousness score aggression hostility,...
We showed previously that macaque monkeys (Macaca mulatta) could orient in real space using abstract visual stimuli presented on a computer screen. They made correct choices according to both spatial (designed as an representation of space) and nonspatial (pictures lacking any inner configuration information). However, we suggested there were differences processing stimuli. In the present experiment show also use cue rotated with respect response space. studied ability decode information...