Sensorimotor gating is the ability of a weak sensory event to inhibit motor response an intense stimulus. Drugs that act as serotonin releasers, such MDMA (3,4-methylenedioxymethamphetamine), impair sensorimotor gating, which measured prepulse inhibition (PPI) acoustic startle response. The first objective present study was compare effect different doses on PPI and (ASR) in male female Wistar rats. second examine across estrous cycle administered 2.5, 5 10 mg/kg s.c. 15 min before start...

Oxytocin is a hormone therapeutically used mainly for its peripheral effects during pregnancy in the uterus and breasts. However, additional central effects, i.e. anxiolytic effect, decreased level of social stress increased empathy have been also observed. Hence, aim our study was to evaluate if nasal oxytocin can be as substance rhesus monkeys (n=20) rabbits (n=20). Simultaneously, mean arterial blood pressure, oxygen saturation hemoglobin pulse rate were monitored all evaluated animals....

This study aimed to link pharmacokinetic (PK) data from different flurbiprofen preparations for the treatment of sore throat with published elucidate whether early efficacy is due local action or a systemic effect after absorption swallowed drug. Three comparative bioavailability studies conducted in healthy subjects provided 8.75 mg formulations, including spray solution, gel, lozenges, and granules. A parallel interstudy comparison was made PK parameters, partial AUCs (pAUCs), using an...

The aim of the study was to compare effect naphthylmedetomidine medetomidine on behavior orangutans and chimpanzees.The immobilization performed as part a medical examination in five chimpanzees three orangutans. Following pre-medication with midazolam (0.70-1.20 mg/kg p.o.), (50-70 microg/kg), or (20-30 microg/kg) given ketamine (3 mg/kg) hyaluronidase (150 M.U.) into musculus deltoideus.We observed distinct anti-aggressive naphthylmedetomidine. shallower influence cardiac frequency less...

Abstract Alpha‐2 adrenoceptors (α 2 ‐ARs) are critically involved in regulating neurotransmitter release from sympathetic nerves and neurons play an important role the regulation of awareness, arousal vigilance. In our recent study, dexmedetomidine, a full α ‐AR agonist, produced antiaggressive effects social conflict test mice at doses that were twice smaller than those producing sedation. The aim this study was to ascertain effect novel drug naphthylmedetomidine, with more selective...

The aim of this study was to compare cardiorespiratory and behavioral profile a new alpha 2-adrenoceptor ligand naphthylmedetomidine with medetomidine in rhesus monkeys.Naphthylmedetomidine or (50 microg/kg) together ketamine (3 mg/kg) hyaluronidase (150 IU/kg) i.m administered 35 monkeys. Behavioral changes were then observed blood pressure, heart rate oxygen saturation hemoglobin.The onset sedation, ataxia, reduction aggression similar both treatment groups. Immobilization only treated...

The aim of this work was to study the effect site intramuscular administration anaesthetic drugs on course immobilisation in macaque monkeys ( Macaca mulatta ). Twenty were given medetomidine (25 µg·kg -1 ) and ketamine (3 mg·kg intramuscularly deltoid (n = 10 animals) or gluteus muscles. Behavioural changes, loss aggressiveness, time cardiorespiratory changes recorded. reversed after 20 min by i.m. atipamezole at dose 250 . Highly significant differences P < 0.001) found between groups...

Benzodiazepines seem to be frequently abused in conjunction with opioids. Fluoxetine was reported block morphine locomotor sensitization rats. Sensitization has been implicated some aspects of drug abuse. We have investigated the effect alprazolam (0.25 mg/kg) and fluoxetine (5 on development expression stimulant (10 mice. produced by daily injections for 10 days. There a clear activity photocell cages but co-administration had no degree sensitization. Alprazolam also without sensitized...

s and Programme: EUROANAESTHESIA 2011: The European Anaesthesiology Congress: Local Regional Anaesthesia

Abstract Background Ephedrine is used in treatment of hypotension during anesthesia. We investigated its effects on the psychomotor recovery and potential adverse reactions cardiorespiratory functions rhesus monkeys. Methods The monkeys received 50 μg/kg medetomidine, 2.0 mg/kg S‐ketamine with 150 IU hyaluronidase i.m. Pulse rate, blood pressure saturation haemoglobin were monitored for 20 minutes. Thereafter, 1 ephedrine or a placebo was administered behavioural changes, pulse every 5...