A5009729391- Granular flow and fluidized beds
- Gene Regulatory Network Analysis
- Sleep and Wakefulness Research
- Landslides and related hazards
- Sleep and related disorders
- Parkinson's Disease Mechanisms and Treatments
- Voice and Speech Disorders
- Receptor Mechanisms and Signaling
- Particle Dynamics in Fluid Flows
- Neuroscience and Neuropharmacology Research
- Statistical Methods and Inference
- Neurotransmitter Receptor Influence on Behavior
- Geotechnical and Geomechanical Engineering
- Alzheimer's disease research and treatments
- Micro and Nano Robotics
- Memory and Neural Mechanisms
- Material Dynamics and Properties
- Cerebral Palsy and Movement Disorders
- Bayesian Methods and Mixture Models
- Balance, Gait, and Falls Prevention
- Tryptophan and brain disorders
- EEG and Brain-Computer Interfaces
- Single-cell and spatial transcriptomics
- Machine Learning in Healthcare
- Intracerebral and Subarachnoid Hemorrhage Research
Takeda (United States)
2019-2024
University of Michigan
2024
University of Rochester
2024
Center for Excellence in Education
2024
University of Rochester Medical Center
2024
Critical Path Institute
2024
Biogen (United States)
2024
Takeda (Japan)
2022-2024
Pfizer (United States)
2013-2021
Takeda (United Kingdom)
2019
The small number of reactant molecules involved in gene regulation can lead to significant fluctuations intracellular mRNA and protein concentrations, there have been numerous recent studies devoted the consequences such noise at regulatory level. Theoretical computational work on stochastic expression has tended focus instantaneous transcriptional translational events, whereas role realistic delay times these processes received little attention. Here, we explore combined effects time...
Using experiments with anisotropic vibrated rods and quasi-2D numerical simulations, we show that shape plays an important role in the collective dynamics of self-propelled (SP) particles. We demonstrate SP exhibit local ordering, aggregation at side walls, clustering absent round Furthermore, find sufficiently strong excitation engage a persistent swirling motion which velocity is strongly correlated particle orientation.
The structure of bacterial populations is governed by the interplay many physical and biological factors, ranging from properties surrounding aqueous media substrates to cell–cell communication gene expression in individual cells. biomechanical interactions arising growth division cells confined environments are ubiquitous, yet little work has focused on this fundamental aspect colony formation. We analyze spatial organization Escherichia coli growing a microfluidic chemostat. find that...
Abstract Psychiatric disorders such as schizophrenia (SCZ), bipolar disorder (BD), and major depressive (MDD) arise from complex interactions between genetic environmental factors. Common variants associated with multiple psychiatric suggest that shared architecture could contribute to divergent clinical syndromes. To evaluate transcriptional alterations across connected brain regions, Affymetrix microarrays were used profile postmortem dorsolateral prefrontal cortex (DLPFC), hippocampus,...
Abstract Digital health technologies can provide continuous monitoring and objective, real-world measures of Parkinson’s disease (PD), but have primarily been evaluated in small, single-site studies. In this 12-month, multicenter observational study, we whether a smartwatch smartphone application could measure features early PD. 82 individuals with early, untreated PD 50 age-matched controls wore research-grade sensors, smartwatch, while performing standardized assessments the clinic. At...
Abstract Objective assessment of Parkinson’s disease symptoms during daily life can help improve management and accelerate the development new therapies. However, many current approaches require use multiple devices, or performance prescribed motor activities, which makes them ill-suited for free-living conditions. Furthermore, there is a lack open methods that have demonstrated both criterion discriminative validity continuous objective in this population. Hence, need systems reduce patient...
Digital measures may provide objective, sensitive, real-world of disease progression in Parkinson's (PD). However, multicenter longitudinal assessments such are few. We recently demonstrated that baseline gait, tremor, finger tapping, and speech from a commercially available smartwatch, smartphone, research-grade wearable sensors differed significantly between 82 individuals with early, untreated PD 50 age-matched controls. Here, we evaluated the change these over 12 months observational...
The partial fluidization model developed by Aranson and Tsimring (2002) is used to simulate the spreading of a 2D circular cap granular material over an erodible bed made same material. Numerical results show that presence even very thin layer lying on solid strongly increases mobility flows. Furthermore, as thickness increases, dynamics flowing mass changes from decelerating avalanche traveling wave. simulation suggest surges are generated if enough entrained, increasing energy balancing...
Selective activation of dopamine D1 receptors (D1Rs) has been pursued for 40 years as a therapeutic strategy neurologic and psychiatric diseases due to the fundamental role D1Rs in motor function, reward processing, cognition. All known D1R-selective agonists are catechols, which rapidly metabolized desensitize D1R after prolonged exposure, reducing agonist response. As such, drug-like selective have remained elusive. Here we report novel series selective, potent non-catechol with promising...
Summary The differential diagnosis of narcolepsy type 1, a rare, chronic, central disorder hypersomnolence, is challenging due to overlapping symptoms with other hypersomnolence disorders. While recent years have seen significant growth in our understanding nocturnal polysomnography 1 features, there remains need for improving methods differentiate nighttime sleep features from those individuals without 1. We aimed develop machine learning framework identifying discriminate clinical...
Recent experimental studies elucidating the importance of noise in gene regulation have ignited widespread interest Gillespie's stochastic simulation technique for biochemical networks. We formulate modifications to Gillespie algorithm which are necessary correctly simulate chemical reactions with time-dependent reaction rates. concentrate on time dependence kinetic rates arising from periodic process growth and division cellular volume, demonstrate that a careful re-derivation is important...
The continuum theory of partially fluidized shear granular flows is tested and calibrated using two-dimensional soft particle molecular dynamics simulations. based on the relaxational order parameter that describes transition between static flowing regimes material. We define as a fraction contacts among all particles. also propose verify by direct simulations constitutive relation splitting stress tensor into a"fluid part" proportional to strain rate tensor, remaining "solid part." ratio...
Large-scale collective motion emerging in a monolayer of vertically vibrated elongated particles is studied. The characterized by recurring swirls, with the characteristic scale exceeding several times size an individual particle. Our experiments identified small horizontal component oscillatory acceleration vibrating plate combination orientation-dependent bottom friction (with respect to acceleration) as source for swirl formation. We developed continuum model operating velocity field and...
Prominent cerebral amyloid angiopathy is often observed in the brains of elderly individuals and almost universally found patients with Alzheimer's disease. Cerebral characterized by accumulation shorter amyloid-β isoform(s) (predominantly amyloid-β40) walls leptomeningeal cortical arterioles likely a contributory factor to vascular dysfunction leading stroke dementia elderly. We used transgenic mice prominent investigate ability ponezumab, an anti-amyloid-β40 selective antibody, attenuate...
Increased protein levels of striatal-enriched tyrosine phosphatase (STEP) have recently been reported in postmortem schizophrenic cortex. The present study sought to replicate this finding a separate cohort samples and extend observations striatum, including subjects with bipolar disorder major depressive the analysis. No statistically significant changes between disease control were found STEP mRNA or dorsolateral prefrontal cortex associative striatum. Although matched for several...
We investigate the dynamics of a dimer bouncing on vertically oscillated plate. The dimer, composed two spheres rigidly connected by light rod, exhibits several modes depending initial and driving conditions. first excited mode has novel horizontal drift in which one end stays plate during most cycle, while other bounces phase with speed direction depend aspect ratio dimer. employ event-driven simulations based detailed treatment frictional interactions between order to elucidate nature...
Wearable digital devices offer potential advantages over traditional methods for the collection of health-related information, including continuous dense data while study subjects are ambulatory or in remote settings. We assessed utility collecting actigraphy and cardiac monitoring by deploying two US Food Drug Administration (FDA) 510(k)-cleared a phase I clinical trial novel compound, which included use an amphetamine challenge. The Phillips Actiwatch Spectrum Pro (Actiwatch) was used to...
Abstract Introduction Few studies have explored whether gait measured continuously within a community setting can identify individuals with Alzheimer's disease (AD). This study tests the feasibility of this method to at earliest stage AD. Methods Mild AD (n = 38) and cognitively normal control (CNC; n 48) participants from University Kansas Disease Center Registry wore GT3x+ accelerometer for 7 days assess gait. Penalized logistic regression repeated five‐fold cross‐validation followed by...