A5112434226- Hepatitis B Virus Studies
- Hepatitis C virus research
- SARS-CoV-2 and COVID-19 Research
- SARS-CoV-2 detection and testing
- COVID-19 Clinical Research Studies
- Immune Response and Inflammation
- Sepsis Diagnosis and Treatment
- Liver Disease Diagnosis and Treatment
- Gastrointestinal motility and disorders
- Inflammasome and immune disorders
- Pain Mechanisms and Treatments
- Long-Term Effects of COVID-19
- Birth, Development, and Health
- Neuroscience of respiration and sleep
- Nutrition and Health in Aging
- GDF15 and Related Biomarkers
- Atherosclerosis and Cardiovascular Diseases
- Inflammation biomarkers and pathways
- Respiratory viral infections research
- Adenosine and Purinergic Signaling
- Infant Health and Development
- Ion Transport and Channel Regulation
- S100 Proteins and Annexins
- Complement system in diseases
- Cancer, Lipids, and Metabolism
Wuhan University
2010-2024
Renmin Hospital of Wuhan University
2010-2024
First Affiliated Hospital of Guangzhou Medical University
2024
State Key Laboratory of Respiratory Disease
2024
Guangzhou Medical University
2024
National Clinical Research
2024
Soochow University
2017-2021
Zhangjiagang First People's Hospital
2018-2021
Second Affiliated Hospital of Soochow University
2017-2020
Henan Agricultural University
2014-2020
Since the outbreak of coronavirus disease 2019 (COVID-19) in Wuhan, China, it has rapidly spread across many other countries. While majority patients were considered mild, critically ill involving respiratory failure and multiple organ dysfunction syndrome are not uncommon, which could result death. We hypothesized that cytokine storm is associated with severe outcome. enrolled 102 COVID-19 who admitted to Renmin Hospital (Wuhan, China). All classified into moderate, critical groups...
Summary Background 2019-Novel coronavirus (2019-nCoV) outbreaks create challenges for hospital laboratories because thousands of samples must be evaluated each day. Sample types, interpretation methods, and corresponding laboratory standards established. The possibility other infections should assessed to provide a basis clinical classification, isolation, treatment. Accordingly, in the present study, we testing methods 2019-nCoV co-infections. Methods We used fluorescence-based quantitative...
Information about the clinical characteristics and mortality of patients with coronavirus disease 2019 at different ages is limited.The older group had more dyspnea fewer fever muscle pain. Older underlying diseases, secondary infection, myocardial injury, renal dysfunction, coagulation immune dysfunction on admission. More received immunoglobulin therapy mechanical ventilation. The proportions multiple organ injuries, critically ill death increased significantly age. groups higher...
Hypertension is one of the most common comorbidities in patients with coronavirus disease 2019 (COVID-19). This study aimed to clarify impact hypertension on COVID-19 and investigate whether prior use renin-angiotensin-aldosterone system (RAAS) inhibitors affects prognosis COVID-19. A total 996 were enrolled, including 282 714 without hypertension. Propensity score-matched analysis (1:1 matching) was used adjust imbalanced baseline variables between 2 groups. Patients further divided into...
Isolation, release and culture of rare circulating tumor cells (CTCs) may, if implemented, promote the progress individualized anti-tumor therapies. To realize CTCs without disruption their viability for further analysis, we designed an effective photocontrolled CTC capture/release system by combination photochemistry immunomagnetic separation. 7-Aminocoumarin was synthesized as phototrigger to bridge connection between anti-EpCAM antibody magnetic beads. The coumarin moieties produced...
The outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has rapidly spread globally. laboratory diagnosis SARS-CoV-2 infection relied on nucleic acid testing; however, it some limitations, such as low throughput and high rates false negatives. Tests higher sensitivity are needed to effectively identify infected patients. This study developed fully automated chemiluminescent immunoassays determine IgM IgG antibodies in human serum. assay performance been evaluated at 10...
Approximately 170 million people in the world are infected with Hepatitis C virus (HCV). There no published population based studies about prevalence of HCV genotypes and associations genotype Infection frequency gender age WuHan. We aimed to investigate distribution among different patients chronic infection WuHan from 2011 2015. A total 2685 anti-HCV positive serum samples individuals physical examinationwere recruited Renmin Hospital University, Hubei Province China January December From...
Cardiac dysfunction is a well-recognized complication of sepsis and seriously affects the prognosis patients. IL-30 has been reported to exert anti-inflammatory effects in various diseases. However, role sepsis-induced myocardial (SIMD) remains unclear. Here, we explored protective cecum ligation puncture (CLP)-induced SIMD mice. expression increased cardiac tissues septic mice was mainly derived from macrophages. deletion or neutralization aggravated injury, whereas recombinant treatment...
To investigate the polymorphisms of interleukin-18 (IL-18) gene promoters, and to disclose whether such are associated with susceptibility chronic hepatitis B in Chinese Han population.Using polymerase chain reaction sequence specific primers (PCR-SSP) method, single nucleotide (SNPs) promoter region IL-18 at position -607 -137 were detected 231 patients 300 normal controls.Allele C was 48.7% controls 51.9% patients, while allele A 51.3% 48.1% patients. The frequencies -607CC, CA -607AA...
To analyze the correlation of polymorphisms toll-like receptor 7 (TLR7) (rs179009) and 9 (TLR9) (rs187084) in hepatitis C virus (HCV) infections Han population.The genotypes TLR7IVS2-151 HCV infection were detected by Sanger sequencing using polymerase chain reaction-restriction fragment length polymorphism to determine TLR9 T-1486C single nucleotide (SNP) for all enrolled patients.We found no significant difference between males with spontaneous clearance versus those chronically infected...
Early identification of biomarkers that can predict the onset sepsis-induced coagulopathy (SIC) in septic patients is clinically important. This study endeavors to examine diagnostic and prognostic utility serum C1q context SIC. Clinical data from 279 diagnosed with sepsis at Departments Intensive Care, Respiratory Infectious Diseases Renmin Hospital Wuhan University were gathered spanning January 2022 2024. These categorized into two groups: SIC group comprising 108 cases non-SIC consisting...
Background and aim Diabetic neuropathic pain is a refractory disabling complication of diabetes mellitus. The pathogenesis the diabetic still unclear, treatment insufficient. this study to investigate roles glucose-6-phosphate dehydrogenase (G6PD) toll-like receptor 4 (TLR4) in rats with diabetes. Methods Type 1 model was induced by intraperitoneal injection streptozotocin (STZ, 75 mg/kg) adult female Sprague-Dawley rats. Paw withdrawal threshold paw latency were measured von Frey filaments...
Objective To investigate the diagnostic value of immunoglobulin M (IgM) and G(IgG) antibodies to 2019 Novel Coronavirus (2019-nCoV) in 2019-nCoV infection. Method This is a retrospective study. Serum samples were collected from 284 patients including outpatients inpatients Renmin Hospital Wuhan University January 20, 2020 February 17, 2020. Among them 205 cases infected patients, 186 confirmed with nucleic acid test 19 diagnosed by clinical symptoms CT characteristics according New...
Bone cancer pain (BCP) is a common pathologic associated with destruction of bone and pathological reconstruction nervous system. Current treatment strategies in clinical inadequate have unacceptable side effects due to the unclear pathology mechanism. In present study, we showed that transplantation Walker 256 cells aggravated mechanical allodynia BCP rats (** p < 0.01 vs. Sham), expression ASIC3 (Acid-sensitive ion channel 3) TRPV1 was obviously enhanced L4-6 dorsal root ganglions...
Growth differentiation factor 15 (GDF15) is involved in the occurrence and development of many diseases, there are few studies on its relationship with sepsis. This article aims to explore clinical value GDF15 sepsis preliminarily prospective regulatory effect macrophage inflammation functions. We recruited 320 subjects (132 cases group, 93 nonsepsis 95 control group), then detected serum levels laboratory indicators, further investigated correlation between also analyzed diagnosis, severity...
Aims Insular cortex is a brain region critical for processing of the sensation. Purinergic receptors are involved in formation chronic pain. The aim present study was to explore role and mechanism P2X3 (P2X3Rs) insular visceral Methods Chronic pain adult rats induced by neonatal maternal deprivation measured detecting threshold colorectal distension. Western blotting, immunofluorescence, real-time quantitative polymerase chain reaction techniques were used detect expression distribution...
AIM:To investigate the relationships between polymorphisms of interleukin-1B (IL-1B) promoter region -511C/T and interleukin-1 receptor antagonist gene (IL-1RN) susceptibility to chronic hepatitis B in Chinese population. METHODS:Genomic DNA was extracted from peripheral blood 190 patients with 249 normal controls then subjected polymerase chain reaction (PCR) amplification.The PCR products were digested by restriction endonuclease AvaI.The digestion 20 g/L gel electrophoresis ethidium...
Irritable bowel syndrome is a disorder of unknown etiology characterized by widespread, chronic abdominal pain associated with altered movements. Increasing amounts evidence indicate that stressors presented during gestational periods could have long-term effects on the offspring’s tissue structure and function, which may predispose to gastrointestinal diseases. The aim present study determine whether prenatal maternal stressis adverse factor affecting sensitivity investigate possible...