A5015017759- Liver Disease Diagnosis and Treatment
- COVID-19 Clinical Research Studies
- Liver physiology and pathology
- SARS-CoV-2 and COVID-19 Research
- Mesenchymal stem cell research
- Organ Transplantation Techniques and Outcomes
- Long-Term Effects of COVID-19
- MicroRNA in disease regulation
- Cancer Research and Treatments
- Liver Disease and Transplantation
- Hepatitis C virus research
- RNA Interference and Gene Delivery
- Hepatitis B Virus Studies
- Advanced biosensing and bioanalysis techniques
- Diet, Metabolism, and Disease
- Macrophage Migration Inhibitory Factor
- Cancer-related Molecular Pathways
- CRISPR and Genetic Engineering
- RNA modifications and cancer
- Telomeres, Telomerase, and Senescence
- COVID-19 epidemiological studies
- Cancer, Hypoxia, and Metabolism
- COVID-19 Impact on Reproduction
- Endoplasmic Reticulum Stress and Disease
- Polyamine Metabolism and Applications
Wuhan University
2012-2025
Renmin Hospital of Wuhan University
2010-2025
Wuhan Institute of Virology
2019
State Key Laboratory of Virology
2019
Zhongnan Hospital of Wuhan University
2003
Huangshi Central Hospital
2003
Since the outbreak of coronavirus disease 2019 (COVID-19) in Wuhan, China, it has rapidly spread across many other countries. While majority patients were considered mild, critically ill involving respiratory failure and multiple organ dysfunction syndrome are not uncommon, which could result death. We hypothesized that cytokine storm is associated with severe outcome. enrolled 102 COVID-19 who admitted to Renmin Hospital (Wuhan, China). All classified into moderate, critical groups...
The coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome 2 (SARS-CoV-2) was identified in December and has subsequently spread worldwide. Currently, there is no effective method to cure COVID-19. Mesenchymal stromal cells (MSCs) may be able effectively treat COVID-19, especially for critical patients. Menstrual blood-derived MSCs have recently received much attention due their superior proliferation ability lack of ethical problems. Forty-four patients were...
Abstract Background: Hypertension and non-alcoholic fatty liver disease (NAFLD) share several pathophysiologic risk factors, the exact relationship between two remains unclear. Our study aims to provide evidence concerning hypertension NAFLD by analyzing data from National Health Nutrition Examination Survey (NHANES) 2017–2018 Mendelian randomization (MR) analyses. Methods: Weighted multivariable-adjusted logistic regression was applied assess using NHANES 2017–2018. Subsequently, a...
Chronic Liver fibrosis may progress to liver cirrhosis and hepatocellular carcinoma (HCC), hence cause a substantial global burden. However, effective therapies for blocking are still lacking. Although mesenchymal stem cells (MSCs) have been proven beneficial regeneration after damage, the underlying mechanism of their therapeutic effects not fully understood. Oxidative stress mitochondrial functionality alteration directly contributes hepatocyte apoptosis development fibrosis. This study...
Abstract Background & Aims The outbreak of coronavirus disease 2019 (COVID‐19) has been declared a pandemic. Although COVID‐19 is caused by infection in the respiratory tract, extrapulmonary manifestations including dysregulation immune system and hepatic injury have observed. Given high prevalence hepatitis B virus (HBV) China, we sought to study impact severe acute syndrome 2 (SARS‐CoV‐2) HBV coinfection patients. Methods Blood samples 50 SARS‐CoV‐2 coinfected patients, 56...
Asymptomatic transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a potential problem for pandemic control through public health strategies. Our results demonstrate that asymptomatic COVID-19 patients have better outcomes than symptomatic patients. This may been due to more active cellular immune responses and normal liver function. Since no clinical symptoms which can easily prevent timely diagnosis treatment, they cause greater risk virus patients, poses major...
Highly biocompatible biomimetic nanoparticles for antibiotic-resistant bacteria infection by photothermal therapy.
Human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) have garnered considerable attention as prospective modalities of treatment for liver fibrosis (LF). The inhibition hepatic stellate cell (HSC) activation underlies the anti-fibrotic effects hUC-MSCs. However, precise mechanism by which hUC-MSCs impede HSC remains unclarified. We aimed to elucidate intrinsic mechanisms underlying therapeutic in LF patients.Mice with cirrhosis induced carbon tetrachloride (CCl4) were used...
Liver fibrosis is a leading cause of liver-related mortality worldwide, yet effective therapies remain limited. Mesenchymal stem cells (MSCs) have recently shown promise in treating liver due to their anti-inflammatory and anti-fibrotic properties. However, the precise molecular mechanisms by which MSCs exert effects unclear. In this study, we explored how human umbilical cord-derived mesenchymal (hUC-MSCs) contribute fibrosis, revealed crucial role ferroptosis modulating hepatic stellate...
Background: The global prevalence of type 2 diabetes mellitus (T2DM) with liver fibrosis is rising, T2DM identified as an independent risk factor and key prognostic for fibrosis. However, the underlying mechanisms remain unclear. Methods: To explore shared pathogenesis T2DM, we analyzed gene expression profiles from GEO database. co-differentially expressed genes (co-DEGs) were subsequently through functional enrichment, protein–protein interaction (PPI) network construction, transcription...
Liver cancer is the sixth most commonly diagnosed and fourth leading cause of death. Most (75–85%) primary liver cancers occurring worldwide are hepatocellular carcinoma (HCC). The development resistance other drug related side effects prime reasons for failure treatment. Therefore, developing high-efficacy low-toxicity natural anticancer agents greatly needed in treatment HCC. Dihydrotanshinone (DHTS) widely used promoting blood circulation antitumor. aim present study was to investigate...
Liver cirrhosis can lead to liver failure and eventually death. Macrophages are the main contributors have a bidirectional role in regulating matrix deposition degradation. Macrophage-based cell therapy has been developed as an alternative transplantation. However, there is insufficient evidence regarding its safety efficacy. In this study, we aimed explore effect of combining insulin-like growth factor 2 (IGF2) with bone marrow-derived macrophages (BMDMs) treat mice cirrhosis.We assessed...
To investigate the expression and significance of PTEN, hypoxia-inducible factor-1 alpha (HIF-1alpha), targeting gene VEGF during colorectal carciogenesis.Total 71 cases neoplasms (9 adenoma 62 adenocarcinoma) were formalin fixed paraffin-embedded, all specimens evaluated for PTEN mRNA, HIF-1alpha mRNA protein expression. detected by in situ hybridization. was identified citrate-microwave SP immunohistochemical method.There significant differences between adenomas adenocarcinoma (P<0.05)....
Liver cirrhosis remains a significant global public health concern, with liver transplantation standing as the foremost effective treatment currently available. Therefore, investigating pathogenesis of and developing novel therapies is imperative. Mitochondrial dysfunction stands out pivotal factor in its development. This study aimed to elucidate relationship between mitochondria using bioinformatic methods unveil pathogenesis. Initially, we identified 460 co-expressed differential genes...