A5039100487- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- SARS-CoV-2 detection and testing
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Hepatitis B Virus Studies
- Ferroptosis and cancer prognosis
- Long-Term Effects of COVID-19
- Cancer-related gene regulation
- Inflammatory Bowel Disease
- RNA Research and Splicing
- Hematopoietic Stem Cell Transplantation
- Hepatitis C virus research
- Gut microbiota and health
- Respiratory viral infections research
- Liver Disease Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Mechanisms of cancer metastasis
- Hearing, Cochlea, Tinnitus, Genetics
- Gastric Cancer Management and Outcomes
- Genetic Associations and Epidemiology
- Viral-associated cancers and disorders
Wuhan University
2014-2025
Shantou University
2025
Shantou University Medical College
2025
Renmin Hospital of Wuhan University
2020-2025
Ruijin Hospital
2024
Shanghai Jiao Tong University
2024
Shanghai Institute of Hematology
2024
Zhongnan Hospital of Wuhan University
2014-2021
Guangdong Pharmaceutical University
2020
National Center for Gene Research
2014
N6-methyladenosine (m6A) in mRNA is the most abundant and reversible modification. However, mechanism behind decrease m6A patients with type 2 diabetes (T2D) has not yet been thoroughly investigated. To clarify whether glucose involved dynamic regulation of T2D to identify a possible underlying mechanism. Liquid chromatography/electrospray ionization/tandem mass spectrometry quantitative PCR were performed determine content expression target genes 102 107 controls. An additional 12 normal...
Summary Background 2019-Novel coronavirus (2019-nCoV) outbreaks create challenges for hospital laboratories because thousands of samples must be evaluated each day. Sample types, interpretation methods, and corresponding laboratory standards established. The possibility other infections should assessed to provide a basis clinical classification, isolation, treatment. Accordingly, in the present study, we testing methods 2019-nCoV co-infections. Methods We used fluorescence-based quantitative...
In December 2019, the coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome 2 (SARS-CoV-2) broke out in Wuhan. Epidemiological and clinical characteristics of patients with COVID-19 have been reported, but relationships between laboratory features viral load has not comprehensively described.Adult inpatients (≥18 years old) who underwent multiple (≥5 times) nucleic acid tests nasal pharyngeal swabs were recruited from Renmin Hospital Wuhan University, including...
Abstract Male infertility is a worldwide medical problem. Asthenozoospermia common cause of infertility. Epigenetic modifications DNA and histones have been shown to influence human infertility, but no research has explored whether N 6 -methyladenosine (m A) level in RNA associated with asthenozoospermia. Here, we collected total 52 semen samples, including 20 asthenozoospermia patients 32 healthy controls. An LC-ESI-MS/MS method was used detect m A contents sperm RNA, real-time PCR...
Sanhuangshu'ai decoction (SH), a traditional Chinese medicine (TCM) prescription, has been safely used to treat diarrhea, dysentery and other inflammatory diseases with little side effect low cost for thousands of years. However, its mechanism remains elusive. This study was designed investigate the anti-ulcerative colitis (UC) activity SH by detecting anti-inflammatory, anti-oxidative, intervention effects intestinal flora dextran sodium sulfate (DSS)-induced mice. The DSS-induced mice...
Abstract STUDY QUESTION Is there a causal relationship between 25-hydroxyvitamin D (25OHD) and miscarriage? SUMMARY ANSWER In this study, little evidence of was found low serum 25OHD concentration or vitamin deficiency the risk miscarriages. WHAT IS KNOWN ALREADY Associations levels increased miscarriage have been reported, but causality is unclear. DESIGN, SIZE, DURATION The latest largest genome-wide association studies (GWAS) for (n = 417 580), (426 cases 354 812 controls), (16 906 149...
Abstract BACKGROUND Hepatocellular carcinoma (HCC) is strongly associated with hepatitis B virus (HBV) infection. False-negative results are common in routine serological tests and quantitative real-time PCR because of HBV surface antigen (HBsAg) variation low copy number. Droplet digital (ddPCR), a next generation PCR, novel, sensitive, specific platform that can be used to improve detection. METHODS A total 131 HCC cases different tumor stages clinical features were initially classified...
(1) Background: Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide with limited treatment satisfaction. Finding new therapeutic targets has remained a major challenge. Ferroptosis an iron-dependent cell death program that plays regulatory role in HBV infection and HCC development. It necessary to classify roles ferroptosis or ferroptosis-related genes (FRGs) HBV-related progression. (2) Methods: We conducted matched case-control study from TCGA database,...
Background: Prostate cancer remains one of the leading causes cancer-related mortality in men worldwide. The treatment it is currently based on surgical removal, radiotherapy, and hormone therapy. It crucial to improve therapeutic prospects for diagnosis prostate via drug target screening. Methods: We integrated eQTL data from eQTLGen Consortium pQTL UK Biobank Proteome Plasma Proteins (UKB-PPP) deCODE health datasets. MR analyses (SMR, heterogeneity dependent instruments (HEIDI), IVW, Wald...
Although some studies have examined the association between triglyceride glucose-body mass index (TyG-BMI) and cardiovascular outcomes in cardio-renal-metabolic (CRM) background, none explored its role progression of CRM multimorbidity. In addition, prior research is limited by small sample sizes a failure to account for competitive effects other diseases. this study, data obtained from large-scale, prospective UK Biobank cohort were used. multimorbidity was defined as new-onset ischemic...
Immune cells are central mediators of the immune response and play critical roles in pathogenesis progression liver diseases. Understanding specific contributions to disease is essential for developing targeted therapeutic strategies. In this study, we employed a two-sample Mendelian randomization (MR) approach explore potential causal relationships between peripheral cell phenotypes diseases, using genetic instrumental variables from large-scale genome-wide association studies (GWAS)....
Although several single-nucleotide polymorphisms in microRNA (miRNA) genes have been associated with primary hepatocellular carcinoma, published findings regarding this relationship are inconsistent and inconclusive. The high-resolution melting (HRM) analysis was used to determine whether the occurrence of SNPs miR-146a C > G (rs2910164), miR-196a2 T (rs11614913), miR-301b A (rs384262), miR-499 (rs3746444) differs frequency-matched 314 HCC patients 407 controls by age sex. groups' genotype...
Abstract Background The SARS-CoV-2 RNA was detected positive again after discharged from hospital in some COVID-19 patients, with or without clinical symptoms such as fever dry cough. Methods 1008 severe the mixed specimen of nasopharyngeal swab and oropharyngeal by real-time fluorescence quantitative PCR (RT-qPCR), were selected to monitor 12 types specimens RT-qPCR during hospitalization. All 20 cases detect isolation period 7 before releasing period. Results Of enrolled showed highest...
The clinical outcomes of hepatocellular carcinoma (HCC) remain dismal. Elucidating the molecular mechanisms for progression aggressive HCC holds promise developing novel intervention strategies. transactivation response element RNA-binding protein (TRBP/TARBP2), a key component microRNA (miRNA) processing and maturation machinery has been shown to play conflicting roles in tumor development progression. We sought investigate expression TARBP2 using well-characterized cell lines,...
Abstract The quality of immune reconstitution (IR) is crucial for the outcome patients who received allogeneic hematopoietic stem cell transplantation (allo-HSCT), and closely connected with infection, relapse graft-versus-host disease (GvHD) which are most important causes failure. However, IR pattern in early stage after allo-HSCT, particularly haploidentical (HID) HSCT, remains unclear. In this retrospective study, we examined T within initial 30 days ( n = 173) 100 122) allo-HSCT...
Abstract Xiaoyankangjun tablet (XYKJP) is a traditional Chinese medicine formulation used to treat intestinal disorders in clinical practice. However, the specific therapeutic mechanism of action XYKJP colitis has not yet been elucidated. This study aimed reveal multifaceted mechanisms treating colitis. The model established based on DSS-induced C57BL/6 mice was employed estimate effect colitis, which then followed by histological assessment, 16S rRNA sequencing, RT-qPCR, ELISA, and Western...
Increasing epidemiological evidence has indicated that inherited variations of mitochondrial DNA (mtDNA) copy number affect the genetic susceptibility many malignancies in a tumour-specific manner and methylation also plays an important role controlling gene expression during differentiation development hepatocellular carcinoma (HCC). Our previous study demonstrated HCC tissues showed lower 5-hydroxymethylcytosine (5-hmC) content when compared to tumour-adjacent tissues, but relationship...