A5102748855- Breast Cancer Treatment Studies
- Breast Lesions and Carcinomas
- Advanced Radiotherapy Techniques
- Breast Implant and Reconstruction
- Brain Metastases and Treatment
- Chemotherapy-induced cardiotoxicity and mitigation
- Cancer Genomics and Diagnostics
- Medical Imaging Techniques and Applications
- Lung Cancer Research Studies
- Cancer Treatment and Pharmacology
- Cancer Diagnosis and Treatment
- HER2/EGFR in Cancer Research
- Viral-associated cancers and disorders
- Esophageal Cancer Research and Treatment
- Glioma Diagnosis and Treatment
- Lymphoma Diagnosis and Treatment
- Metastasis and carcinoma case studies
- Gastric Cancer Management and Outcomes
- Radiation Dose and Imaging
- BRCA gene mutations in cancer
- MicroRNA in disease regulation
- Ubiquitin and proteasome pathways
- Bone fractures and treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Lung Cancer Diagnosis and Treatment
Shanghai Jiao Tong University
2016-2025
Ruijin Hospital
2015-2025
Shandong First Medical University
2023
Shandong Tumor Hospital
2023
Affiliated Hospital of Guizhou Medical University
2020-2022
Guiyang Medical University
2020-2022
Nantong University
2014-2020
Second Affiliated Hospital of Nantong University
2014-2020
Affiliated Hospital of Nantong University
2014-2020
Fudan University Shanghai Cancer Center
2010-2019
Abstract Background Conventional post-mastectomy radiation therapy is delivered with tangential fields for chest wall and separate regional nodes. Although nodes delineation has been discussed RTOG contouring atlas, CT-based planning to treat as a whole target not widely accepted. We herein discuss the dosimetric characteristics of linac IMRT technique treating PTV after modified radical mastectomy, observe acute toxicities following irradiation. Methods Patients indicated PMRT were...
Metabolic reprogramming plays an essential role on lymphoma progression. Dysregulation of glutamine metabolism is implicated in natural-killer T-cell (NKTCL) and tumor cell response to asparaginase-based anti-metabolic treatment.To understand the metabolomic alterations determine potential therapeutic target asparaginase, we assessed profile using liquid chromatography-mass spectrometry serum samples 36 NKTCL patients, integrated targeted metabolic analysis RNA sequencing 102 patients. The...
This study aims to assess whether dual anti-HER2 therapy with trastuzumab and pertuzumab increases early cardiac toxicity compared alone in breast cancer (BC) patients receiving postoperative radiation (RT). Consecutive operable BC RT or without between January 2017 September 2020 at seven tertiary hospitals China were retrospectively reviewed. Cardiac examinations included echocardiography, electrocardiogram (ECG), NT-proBNP, cTnI baseline before during the follow-up. The event is any...
To characterize the differences of dynamic changes for absolute lymphocyte count (ALC) among esophageal squamous cell carcinoma (ESCC) patients treated with neoadjuvant chemoradiotherapy (nCRT) or without pembrolizumab, as well to investigate clinical and lymphocyte-related organs dosimetric parameters that would impact ALC nadir during nCRT. A total 216 ESCC who received nCRT (with pembrolizumab 144; pembrolizumab: 72) were identified from a prospective cohort. Weekly 1-month post-nCRT...
133 Background: Total neoadjuvant therapy (TNT) intensified by the combination of targeted or immunotherapy is warranted to achieve satisfying local and systemic control for high-risk locally advanced rectal cancer (LARC). Our study aimed explore efficacy safety a FOLFOX-based TNT regimen plus bevacizumab short-course radiotherapy (SCRT) in Ras-mutant LARC patients. Methods: In this single-arm, single-center, phase II trial, patients with at least one risk factor (cT3c-4, mesorectal fascia...
BackgroundA phase II study of methotrexate, etoposide, dexamethasone, and pegaspargase (MESA) sandwiched with radiotherapy for newly diagnosed, stage IE-IIE extranodal natural-killer/T-cell lymphoma, nasal-type (ENKTL) was conducted to explore its clinical efficacy safety, as well novel serum biomarkers upon anti-metabolic treatment.MethodsFour cycles MESA were administered. The primary end point the overall response rate (ORR). Serum metabolomic profiles assessed by liquid...
Abstract Background. Left ventricular ejection fraction (LVEF) is used routinely to monitor cardiac dysfunction associated with breast cancer treatment. In this study the prevalence of early left diastolic (LVDD) and its relationship dose-volume heart irradiated were evaluated in HER2-positive patients undergoing concurrent trastuzumab adjuvant radiotherapy (RT). Materials Methods. Data from 40 treated left-sided RT between September 2011 October 2012 collected prospectively. For comparison,...
The multi-center randomized phase 3 NHL-004 study compared etoposide, dexamethasone and pegaspargase (ESA) versus methotrexate, (MESA) regimen, combined with sandwiched radiotherapy, in newly diagnosed early-stage nasal natural killer/T-cell lymphoma (NKTCL). Here we report the long-term outcomes (median follow-up, 64 months) biomarker analysis. 256 eligible patients aged 14-70 years were randomly assigned (1:1) to ESA or MESA arm. 5-year progression-free survival (PFS) rates 80.3% 74.9%...
Many studies have shown that the peripheral blood inflammatory index and nutritional index, such as platelet lymphocyte ratio (PLR), neutrophil (NLR), monocyte (LMR), systemic inflammation response (SIRI), pan-immune-inflammation value (PIV), immune-inflammation (SII), prognostic nutrition (PNI), are independent factors for tumors. The present study aimed to investigate role of these indexes before treatment in locally advanced gastric cancer (LAGC) treated with adjuvant chemoradiotherapy...
To evaluate the influence of concurrent trastuzumab on cardiotoxicity in patients receiving left-sided adjuvant radiotherapy.Medical records stage I-III breast cancer patients, including 64 with radiotherapy and 73 alone were retrospectively reviewed. All had normal LVEF after chemotherapy. Information doses volume to cardiac structures was collected. Cardiac events assessed according CTC 2.0.Median follow-up clinical assessment function from initiation 6.7 months (range 3-60.9) 26...
Lacking quantitative evaluations of clinicopathological features and the risk factors for loco-regional recurrence (LRR) in gastric cancer after D2 gastrectomy, we aimed to develop a competing nomogram identify predictors initial LRR.We retrospectively analysed 1105 patients who underwent radical gastrectomy with resection stage I-III cancer. A predicting LRR was conducted based on Fine Grey's analysis. The predictive accuracy discriminative ability model were determined using concordance...
Methotrexate, etoposide, dexamethasone, and pegaspargase (MESA) with sandwiched radiotherapy is known to be effective for early-stage extranodal natural killer/T-cell lymphoma, nasal type (NKTCL). We explored the efficacy safety of reduced-intensity, non-intravenous (ESA) radiotherapy. This multicenter, randomized, phase III trial enrolled patients aged between 14 70 years newly diagnosed NKTCL from 27 centers in China. Patients were randomly assigned (1:1) receive ESA (pegaspargase 2,500...
Abstract Background The cone beam CT (CBCT) guided radiation can reduce the systematic and random setup errors as compared to skin-mark setup. However, residual intrafractional (RAIF) are still unknown. purpose of this paper is investigate magnitude RAIF correction action levels needed in computed tomography accelerated partial breast irradiation (APBI). Methods Ten patients were enrolled prospective study CBCT APBI. postoperative tumor bed was irradiated with 38.5 Gy 10 fractions over 5...
The benefit of adjuvant trastuzumab in disease-free and overall survival for human epidermal receptor 2–positive (HER2+) breast cancer patients is well established. However, the effect on locoregional control remains unclear, particularly treated with radiotherapy (RT). In this study, we investigated HER2+ after RT. Using a single institutional database, identified 278 stage II/III invasive tumors receiving RT between January 2008 July 2011. We compared outcomes 134 who received to 144...
Hippocampus avoidance in whole brain radiotherapy (HA-WBRT) offers the feasibility of less-impaired cognitive function than conventional WBRT. The study aims to assess radiological distribution metastases (BMs) with relation hippocampus and peri-hippocampus region as defined by RTOG 0933 for better understanding margin definition HA-WBRT treatment planning.Consecutive patients diagnosis BM from enhanced MRI between March 2011 July 2016 were analysed. pre-treatment T1 weighted, T2 flair,...
Deregulated expression of C-terminal-binding protein 2 (CTBP2) has been observed previously in a number tumors, such as hepatocellular carcinoma and prostatic cancer, the colorectal cancer SW480 cell line human embryonic kidney 293 line. In present study, western blot analysis immunohistochemistry were performed to investigate whether gliomas exhibit deregulated CTBP2 expression. Kaplan-Meier survival analyses evaluate associations between expression, clinicopathological data patient glioma...