A5101759910- Colorectal Cancer Surgical Treatments
- Gastric Cancer Management and Outcomes
- Colorectal Cancer Screening and Detection
- Colorectal and Anal Carcinomas
- Genetic factors in colorectal cancer
- Radiomics and Machine Learning in Medical Imaging
- Anorectal Disease Treatments and Outcomes
- Colorectal Cancer Treatments and Studies
- Hernia repair and management
- Minimally Invasive Surgical Techniques
- Appendicitis Diagnosis and Management
- Cancer Genomics and Diagnostics
- Abdominal Surgery and Complications
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Maritime Transport Emissions and Efficiency
- Nanoplatforms for cancer theranostics
- Surgical Simulation and Training
- Anatomy and Medical Technology
- Gastrointestinal disorders and treatments
- Pediatric Urology and Nephrology Studies
- COVID-19 Pandemic Impacts
- Lymphatic Disorders and Treatments
- Bladder and Urothelial Cancer Treatments
- SARS-CoV-2 and COVID-19 Research
- COVID-19 epidemiological studies
Ruijin Hospital
2015-2025
Shanghai Jiao Tong University
2015-2024
Shanghai Maritime University
2023
Peking University
2020
Peking University Shenzhen Hospital
2000
Importance Previous studies have demonstrated the advantages of short-term histopathological outcomes and complications associated with transanal total mesorectal excision (TME) compared laparoscopic TME. However, long-term oncological TME remain ambiguous. This study aims to compare 3-year disease-free survival Objective To evaluate between in patients rectal cancer. Design, Setting, Participants randomized, open-label, noninferiority, phase 3 clinical trial was performed 16 different...
Abstract The current outbreak of coronavirus disease 2019 (COVID-19) has become a global crisis due to its quick and wide spread over the world. A good understanding dynamic would greatly enhance control prevention COVID-19. However, best our knowledge, unique features have limited applications all existing models. In this paper, novel stochastic model is proposed which aims account for transmission dynamics COVID-19 capture effects intervention measures implemented in Mainland China. We...
Abstract Photodynamic therapy (PDT) has emerged as an attractive therapeutic approach which can elicit immunogenic cell death (ICD). However, current ICD inducers are still very limited the representative induces of photosensitizers only evoke insufficient to achieve unsatisfactory cancer immunotherapy. Herein, we demonstrated use a triple action cationic porphyrin-cisplatin conjugate (Pt-1) for drug delivery by reactive oxygen species (ROS) sensitive polymer nanoparticles (NP@Pt-1) combined...
N-myc downstream-regulated gene 1 (NDRG1) has been shown to play a key role in tumor metastasis. Recent studies demonstrate that NDRG1 can suppress growth and is related proliferation; however, the mechanisms underlying these effects remain obscure.Immunohistochemistry (IHC) was used detect p21 protein expression colorectal cancer tissue, clinical significance of also analyzed. CCK-8 assay, colony formation flow cytometry, xenograft model were assess effect on proliferation vivo vitro. The...
133 Background: Total neoadjuvant therapy (TNT) intensified by the combination of targeted or immunotherapy is warranted to achieve satisfying local and systemic control for high-risk locally advanced rectal cancer (LARC). Our study aimed explore efficacy safety a FOLFOX-based TNT regimen plus bevacizumab short-course radiotherapy (SCRT) in Ras-mutant LARC patients. Methods: In this single-arm, single-center, phase II trial, patients with at least one risk factor (cT3c-4, mesorectal fascia...
Multiple linear stapler firings during double stapling technique (DST) after laparoscopic low anterior resection (LAR) are associated with an increased risk of anastomotic leakage (AL). However, it is difficult to predict preoperatively the need for multiple cartridges DST anastomosis.
Robotic surgery has been widely adopted for colorectal cancer (CRC). Many surgeons in China have completed structured training programs and performed robotic surgeries. This multicenter study aimed to evaluate the effects of curricula with different laparoscopic experiences during their initial implementation surgery.Ten from five high-volume centers participated this retrospective study. The baseline characteristics, perioperative data, pathological outcomes were compared between first 15...
We assessed the association between microsatellite instability-high (MSI-H) and tumor response to neoadjuvant chemotherapy (NAC) as well its prognostic relevance in patients with clinical stage III gastric cancer (cStage GC).The NAC + surgery control cohorts consisted of 177 513 cStage GC patients, respectively. The pathological features were compared MSI-H [n=57 (8.3%)] stability or instability-low (MSS/MSI-L) [n=633 (91.7%)]. Radiological histological evaluated based on evaluation criteria...
Abstract Background and Objectives Evidence supporting the importance of apical lymph nodes (LNs) potential long‐term impact LN metastases at inferior mesenteric artery (IMA) lymphectomy remains limited. This study aimed to evaluate prognostic value LNs IMA (IMA‐LN) in sigmoid rectal cancer patients undergoing laparoscopic surgery. Methods We retrospectively evaluated 265 consecutive who underwent or surgery between August 2016 May 2020. They were divided into two groups according...
Background: With the optimization of neoadjuvant treatment regimens, indications for intersphincteric resection (ISR) have expanded. However, limitations such as unclear surgical field, impaired anal function, and failure preservation still exist. Transanal total mesorectal excision can complement drawbacks ISR. Therefore, this study combined these two techniques proposed transanal endoscopic (taE-ISR), aiming to explore value novel technique in ultra-low rectal cancer. Material methods:...
Conventional laparoscopic-assisted right hemicolectomy requires a small abdominal incision to extract the specimen, which becomes an important source of postoperative complications and impairs perioperative experience. Transvaginal natural orifice specimen extraction surgery (NOSES VIIIA) avoids this by extracting through vagina. Here we describe design multicenter, open-label, parallel, noninferior, phase III randomized controlled trial (NCT 05495048). The aim study is confirm that NOSES...
Multiple linear stapler firings is a risk factor for anastomotic leakage (AL) in laparoscopic low anterior resection (LAR) using double stapling technique (DST) anastomosis. In this study, our objective was to establish the factors ≥ 3 firings, and create validate predictive model LAR DST We retrospectively enrolled 328 mid-low rectal cancer patients undergoing With split ratio of 4:1, were randomly divided into 2 sets: training set (n = 260) testing 68). A clinical constructed by binary...
The incidence of acute gastrointestinal injury (AGI) after colorectal surgery is low when laparoscopic techniques are used. While elevated intra-abdominal pressure (IAP) and hypertension (IAH) associated with AGI grade II, little known about the relation between increased IAP during laparoscopy subsequent AGI.To assess impact on postoperative AGI.Sixty-six patients (41 men 25 women) cancer undergoing elective were randomized into 3 groups, according to different levels CO2 pneumoperitoneum...
Background: To investigate the application value of 4K high definition (HD) in laparoscopic gastrectomy by comparing short-term outcomes and subjective perception with three-dimensional (3D) HD vision systems. Materials Methods: A retrospective study was conducted between September 2018 February 2019; a total 87 patients who underwent were enrolled divided into three groups terms different type system used for surgery: 4K, 3D, HD. Demographic clinicopathological data as well collected...
Abstract Background The impact of microsatellite status on lymph node (LN) yield during lymphadenectomy and pathological examination has never been assessed in gastric cancer (GC). In this study, we aimed to appraise the association between instability-high (MSI-H) LN after curative gastrectomy. Methods We retrospectively analyzed 1757 patients with GC undergoing gastrectomy divided them into two groups: MSI-H ( n = 185(10.5%)) stability (MSS) 1572(89.5%)), using a five-Bethesda-marker...
Tumor localization is a key step in laparoscopic colorectal surgery. Endoscopic tattooing widely practiced with satisfactory accuracy, whereas few studies have investigated its shortcomings. The aim of our study to assess the accuracy and efficiency tumor protocol without endoscopic tattooing.The was performed for 788 cancer/polyp patients undergoing resection. evaluated by intraoperative exploration anatomopathologic results.The 100% study. drawbacks were overcome. Only 16.6% underwent...
In the case of right-sided transverse colon cancer (RTCC) and hepatic flexure (HFCC), there is a potential connection lymph drainage between mesentery greater omentum. However, most previous reports have been limited series with No. 206 204 node (LN) dissection for RTCC HFCC.The InCLART Study prospective observational study aiming to enrol 427 patients HFCC treated at 21 high-volume institutions in China. The prevalence infrapyloric (No. 206) curvature 204) LN metastasis short-term outcomes...
The aim of this study was to compare the pathological and perioperative outcomes extracorporeal versus intracorporeal anastomosis after laparoscopic transverse colon cancer resection.In retrospective study, patients from seven institutions in China who underwent resection between 2019 2021 were selected included. Either extended right hemicolectomy or colectomy/extended left performed. clinical characteristics compared undergoing anastomosis. Resection margin lengths measured on...
Transanal total mesorectal excision (TaTME) is an alternative for mid-low rectal cancer. In China, this procedure has been performed in high-volume centers with structured training curriculums. The efficacy of the TaTME curriculums China still unclear. This multicenter study aimed to explore effectiveness China.Seven participated study. first 25 patients who underwent each center were enrolled. cohort, divided into 3 groups. 5 procedures (group 1) under proctoring according requirement...