A5100784172- Sleep and related disorders
- Sleep and Wakefulness Research
- Gastric Cancer Management and Outcomes
- Circadian rhythm and melatonin
- Hernia repair and management
- Obstructive Sleep Apnea Research
- RNA modifications and cancer
- Gastrointestinal Tumor Research and Treatment
- Colorectal Cancer Surgical Treatments
- Pelvic and Acetabular Injuries
- Cancer Immunotherapy and Biomarkers
- Gastroesophageal reflux and treatments
- Gastrointestinal disorders and treatments
- Esophageal and GI Pathology
- COVID-19 and Mental Health
- Dietary Effects on Health
- Ferroptosis and cancer prognosis
- Dysphagia Assessment and Management
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Sperm and Testicular Function
- Metastasis and carcinoma case studies
- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- Cancer Mechanisms and Therapy
- Colorectal and Anal Carcinomas
Uppsala University
2021-2025
Ruijin Hospital
2013-2024
Shanxi Eye Hospital
2024
Shanghai Jiao Tong University
2012-2024
University of Maryland, Baltimore
2023
Beijing University of Chinese Medicine
2014-2023
University of Maryland Medical Center
2023
West China Hospital of Sichuan University
2016-2022
Sichuan University
2014-2022
State Key Laboratory of Biotherapy
2018-2021
Abstract Background N6-methyladenosine (m6A) is the most prevalent RNA epigenetic regulation in eukaryotic cells. However, understanding of m6A colorectal cancer (CRC) very limited. We designed this study to investigate role CRC. Methods Expression level METTL14 was extracted from public database and tissue array clinical relevance Next, gain/loss function experiment used define progression Moreover, transcriptomic sequencing (RNA-seq) applied screen potential targets METTL14. The specific...
Back to table of contents Previous article Next CommentaryFull AccessMental Health Response the COVID-19 Outbreak in ChinaJunying Zhou, M.D., Ph.D., Liu Liu, Pei Xue, Xiaorong Yang, B.N., Xiangdong Tang, Ph.D.Junying Ph.D.Published Online:7 May 2020https://doi.org/10.1176/appi.ajp.2020.20030304AboutSectionsPDF/EPUB ToolsAdd favoritesDownload CitationsTrack Citations ShareShare onFacebookTwitterLinked InEmail Transmission 2019 novel coronavirus (COVID-19) (1) has now widely and rapidly spread...
Abstract Aberrant sperm flagella impair motility and cause male infertility, yet the genes which have been identified in multiple morphological abnormalities of (MMAF) can only explain pathogenic mechanisms MMAF a small number cases. Here, we identify functionally characterize homozygous loss-of-function mutations QRICH2 two infertile males with from consanguineous families. Remarkably, Qrich2 knock-out (KO) mice constructed by CRISPR-Cas9 technology present phenotypes sterility. To...
Importance Understanding the interplay between sleep duration, dietary habits, and risk of developing type 2 diabetes (T2D) is crucial for public health prevention strategies. Objective To investigate associations diet duration with development T2D. Design, Setting, Participants Data derived from UK Biobank baseline investigation (2006-2010) were analyzed this cohort study May 1 September 30, 2023. The association healthy patterns T2D was investigated during a median (IQR) follow-up 12.5...
Immunophenotyping of the tumor microenvironment (TME) is essential for enhancing immunotherapy efficacy. However, strategies characterizing TME exhibit significant heterogeneity. Here, we show that endoplasmic reticular oxidoreductase-1α (ERO1A) mediates an immune-suppressive and attenuates response to PD-1 blockade. Ablation ERO1A in cells substantially incites anti-tumor T cell immunity promotes efficacy aPD-1 therapeutic models. Single-cell RNA-sequencing analyses confirm correlates with...
Short nighttime sleep duration impairs the immune response to virus vaccination, and long is associated with poor health status. Thus, we hypothesized that short (<6 h) (>9 sleepers have a higher post-COVID risk than normal sleepers, despite two doses of mRNA vaccine (which has previously been linked lower odds long-lasting COVID-19 symptoms). Post-COVID was defined as experiencing at least one core symptom for three months (e.g., shortness breath). Multivariate logistic regression adjusting...
N-myc downstream-regulated gene 1 (NDRG1) has been shown to play a key role in tumor metastasis. Recent studies demonstrate that NDRG1 can suppress growth and is related proliferation; however, the mechanisms underlying these effects remain obscure.Immunohistochemistry (IHC) was used detect p21 protein expression colorectal cancer tissue, clinical significance of also analyzed. CCK-8 assay, colony formation flow cytometry, xenograft model were assess effect on proliferation vivo vitro. The...
Abstract Background Preliminary data suggests that obesity might hasten the decline in mRNA vaccine-induced immunity against SARS-CoV-2. However, whether this renders individuals with more susceptible to long COVID symptoms post-vaccination remains uncertain. Given sleep’s critical role immunity, exploring associations between obesity, probable symptoms, and sleep disturbances is essential. Methods We analyzed from a survey of 5919 adults aged 18 89, all whom received two SARS-CoV-2...
Abstract Background Lifestyle choices, such as dietary patterns and sleep duration, significantly impact the health of digestive system may influence risk mortality from cancer. Methods This study aimed to examine associations between habits, cancers. The analysis included 406,584 participants UK Biobank cohort (54.1% women; age range: 38–73 years), with duration classified short (≤ 6 h, 24.2%), normal (7–8 68.4%), long (≥ 9 7.4%). Healthy eating habits were defined a daily intake at least...
To discuss the learning curve of laparoscopy-assisted distal gastrectomy (LADG) with lymph node dissection and oncological results long-term outcomes different periods in stage.One hundred twenty-four patients gastric cancer who received LADG from January 2004 to December 2009 were retrospectively reviewed analyzed. They divided into three groups (A-C) according operative date: 41 Group A (early), B (middle), 42 C (laer). There no significant statistical differences among respect age,...
Abstract The present study aimed to evaluate the relationship between OSA and adenotonsillar size in children of different weight status. A total 451 patients aged 2–13 years with suspected were retrospectively enrolled study. Correlations apnea-hypopnea index (AHI) status investigated. adenoidal/nasopharyngeal (A/N) ratio underweight was significantly higher than that normal-weight ( P = 0.027). Both adenoid tonsil positively correlated logAHI normal (r 0.210, 0.001; r 0.212, 0.001) but...
Background The endoplasmic reticulum oxidoreductin-1-like ( ERO1L ) gene encodes an luminal localized glycoprotein known to associated with hypoxia, however, the role of in shaping tumor immune microenvironment (TIME) is yet be elucidated lung adenocarcinoma (LUAD). Methods In this study, raw datasets (including RNA-seq, methylation, sgRNA-seq, phenotype, and survival data) were obtained from public databases. This data was analyzed used explore biological landscape infiltration. Expression...
Aberrations in MYC underlie a large proportion of liver hepatocellular carcinoma (LIHC) cases; however, is difficult to target because its undruggable structure. We aimed uncover MYC-associated molecular targets provide new strategies for LIHC treatment.LIHC transcriptome datasets and clinical information were obtained from The Cancer Genome Atlas. A series bioinformatics analyses performed 370 patients who stratified based on the median expression level (high-MYC group low-MYC group)....
Personalized and novel evidence-based clinical treatment strategy consulting for colorectal cancer has been available through various artificial intelligence (AI) supporting systems such as Watson Oncology (WFO) from IBM. However, the potential effects of this tool in care have not thoroughly explored real-world studies. This research aims to investigate concordance between recommendations patients made by WFO a multidisciplinary team (MDT) at major comprehensive gastrointestinal center. In...
Abstract Testis-specific protein Y-linked 1 (TSPY1) is expressed predominantly in adult human spermatogonia and functions the process of spermatogenesis; however, our understanding underlying mechanism limited. Here we observed that TSPY1, as an interacting partner TSPY-like 5 (TSPYL5), enhanced competitive binding TSPYL5 to ubiquitin-specific peptidase 7 (USP7) conjunction with p53. This activity, together its promotion expression by acting a transcription factor, resulted increased p53...
Trastuzumab has been prevailingly accepted as a beneficial treatment for gastric cancer (GC) by targeting human epidermal growth factor receptor 2 (HER2)-positive. However, the therapeutic resistance of trastuzumab remains major obstacle, restricting efficacy. Therefore, identifying potential key genes and pathways is crucial to maximize overall clinical benefits.The gene expression profile GSE77346 was retrieved identify differentially expressed (DEGs) associated with in GC. Next, DEGs were...
Summary Weighted blankets have emerged as a potential non‐pharmacological intervention to ease conditions such insomnia and anxiety. Despite lack of experimental evidence, these alleged effects are frequently attributed reduced activity the endogenous stress systems an increased release hormones oxytocin melatonin. Thus, aim present in‐laboratory crossover study (26 young healthy participants, including 15 men 11 women) was investigate if using weighted blanket (~12% body weight) at bedtime...