A5102827429- Sperm and Testicular Function
- Reproductive Biology and Fertility
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Sexual Differentiation and Disorders
- Renal and related cancers
- Prenatal Screening and Diagnostics
- Reproductive Health and Technologies
- Urologic and reproductive health conditions
- Animal Genetics and Reproduction
- Lung Cancer Diagnosis and Treatment
- Assisted Reproductive Technology and Twin Pregnancy
- Plant nutrient uptake and metabolism
- Chromosomal and Genetic Variations
- Pluripotent Stem Cells Research
- Nuclear Structure and Function
- Plant Micronutrient Interactions and Effects
- Ovarian function and disorders
- CRISPR and Genetic Engineering
- Magnesium in Health and Disease
- Lung Cancer Treatments and Mutations
- Radiomics and Machine Learning in Medical Imaging
- Hormonal and reproductive studies
- Plant Reproductive Biology
- COVID-19 Impact on Reproduction
- Microtubule and mitosis dynamics
First People's Hospital of Yunnan Province
2025
Second Affiliated Hospital of Jilin University
2025
Nanjing Medical University
2015-2024
Jiangsu Province Hospital
2011-2024
Shanghai Ninth People's Hospital
2024
Shanghai Jiao Tong University
2024
Taizhou People's Hospital
2024
Nantong University
2024
Zhoukou Normal University
2024
Beijing Normal University
2024
Abstract Aberrant sperm flagella impair motility and cause male infertility, yet the genes which have been identified in multiple morphological abnormalities of (MMAF) can only explain pathogenic mechanisms MMAF a small number cases. Here, we identify functionally characterize homozygous loss-of-function mutations QRICH2 two infertile males with from consanguineous families. Remarkably, Qrich2 knock-out (KO) mice constructed by CRISPR-Cas9 technology present phenotypes sterility. To...
Macroautophagy/autophagy is indispensable for testosterone synthesis in Leydig cells (LCs), and here we report a negative association between m6A modification autophagy LCs during synthesis. A gradual decrease of METTL14 (methyltransferase like 14) an increase ALKBH5 (alkB homolog 5, RNA demethylase) were observed their differentiation from stem to adult LCs. These events led reduced mRNA methylation levels N6-methyladenosine (m6A) enhanced Similar regulation METTL14, ALKBH5, was also upon...
SUN (Sad1 and UNC84 domain containing)-domain proteins are reported to reside on the nuclear membrane playing distinct roles in dynamics. SUN5 is a new member of family, with little knowledge regarding its function. Here, we generated Sun5-/- mice found that male were infertile. Most Sun5-null spermatozoa displayed globozoospermia-like phenotype but they actually acephalic spermatozoa. Additional studies revealed was located neck spermatozoa, anchoring sperm head tail, without functional...
Abstract Background As of March 11, 2020, the COVID-19 outbreak was declared as a pandemic. Expending our understanding transmission routes viral infection is crucial in controlling outbreak. It unclear whether 2019 novel coronavirus (2019-nCoV) can directly infect testes or male genital tract and be sexually transmitted from males. Methods From January 31 to 14, 12 patients recovery one patient died were included this descriptive study. The clinical characteristics, laboratory findings,...
Inner dynein arm (IDA), composed of a series protein complex, is necessary to cilia and flagella bend formation beating. Previous studies indicated that defects IDA complex result in multiple morphological abnormalities the sperm flagellum (MMAF) male infertility. However, genetic causes molecular mechanisms IDAs need further exploration. Here we identified two loss-of-function variants WDR63 both MMAF non-obstructive azoospermia (NOA) affected cohorts. encodes an IDA-associated dominantly...
This study aimed to investigate the impact of low-intensity pulsed ultrasound (LIPUS) treatment on miRNA and mRNA profiles stem cell-derived extracellular vesicles (EVs). Specifically, it sought identify key miRNAs their target mRNAs associated with enhanced therapeutic efficacy in LIPUS-treated EVs. Utilizing deep-sequencing data from Gene Expression Omnibus database, differential gene analysis was performed. MiRNA-mRNA analysis, functional pathway enrichment protein-protein interaction...
Are Sad1 and UNC84 domain containing 5 (SUN5) mutations associated with the outcomes of ICSI in patients acephalic spermatozoa syndrome (ASS)? Despite highly abnormal sperm morphology, ASS SUN5 have a favorable pregnancy outcome following ICSI. is rare cause infertility characterized by production majority headless spermatozoa, along small proportion intact an head–tail junction. Previous studies demonstrated that may ASS. Several showed could help father children. This retrospective cohort...
Abstract Oligoasthenozoospermia is a major cause of male infertility; however, its etiology and pathogenesis are unclear may be associated with specific gene abnormalities. This study focused on Tppp2 (tubulin polymerization promoting protein family member 2), whose encoded localizes in elongating spermatids at stages IV‐VIII the seminiferous epithelial cycle testis mature sperm epididymis. In human mouse sperm, vitro inhibition TPPP2 caused significantly decreased motility ATP content....