A5103088367- Pluripotent Stem Cells Research
- RNA and protein synthesis mechanisms
- RNA Research and Splicing
- RNA modifications and cancer
- Renal and related cancers
- Congenital heart defects research
Nanjing Medical University
2023-2025
Abstract Embryo loss and pregnancy disorders are prevalent worldwide, with both conditions critically associated dysfunctioning gastrulation processes. Gastrulation post-gastrulation organogenesis crucial stages of embryonic development that establish the blueprint for body part formation. These processes involve sequential generation three germ layer cells primordial cells, as well assembly precursor tissues parts. However, due to ethical limitations studying human embryogenesis, a more...
Despite continuous expansion of the RNA binding protein (RBP) world, there is a lack systematic understanding RBPs in mammalian testis, which harbors one most complex tissue transcriptomes. We adapted interactome capture to mouse male germ cells, building an RBP atlas characterized by multiple layers dynamics along spermatogenesis. Trapping RNA-cross-linked peptides showed that glutamic acid-arginine (ER) patch, residue-coevolved polyampholytic element present coiled coils, enhances its host...
Primordial germ cells (PGCs), the precursors of oocytes or spermatozoa, are highly pluripotent. In recent years, in vitro induction human primordial cell-like (hPGCLCs) has advanced significantly. However, stability and efficacy obtaining hPGCLCs still require further improvement. current study, we identified a novel system by using Dulbecco's Modified Eagle Medium/Nutrient Mixture F-12 (DMEM/F-12) as basal medium supplemented with B27 N2 (referred to N2B27) combination four cytokines: bone...