A5102021858- RNA modifications and cancer
- Cancer-related gene regulation
- RNA and protein synthesis mechanisms
- Epigenetics and DNA Methylation
- Hedgehog Signaling Pathway Studies
- RNA Research and Splicing
- Cancer, Hypoxia, and Metabolism
- Cancer Cells and Metastasis
- Angiogenesis and VEGF in Cancer
- Cancer-related molecular mechanisms research
- Tendon Structure and Treatment
- Bacterial Genetics and Biotechnology
- CRISPR and Genetic Engineering
- Signaling Pathways in Disease
- Wnt/β-catenin signaling in development and cancer
- Foot and Ankle Surgery
- Glycosylation and Glycoproteins Research
- Biochemical and Molecular Research
- Cancer Research and Treatments
- Cancer Genomics and Diagnostics
- RNA regulation and disease
- Protease and Inhibitor Mechanisms
- Cancer Mechanisms and Therapy
- Salmonella and Campylobacter epidemiology
- Ferroptosis and cancer prognosis
Nanjing Medical University
2018-2024
Xuzhou Medical College
2023
National Medical Products Administration
2023
Yangzhou University
2018-2022
Jiangsu Cancer Hospital
2019-2022
Zhejiang University
2022
China Medical University
2021-2022
Liaoning Cancer Hospital & Institute
2022
Tianjin Medical University Cancer Institute and Hospital
2021
Huazhong University of Science and Technology
2020
Yeasts and filamentous fungi do not have adenosine deaminase acting on RNA (ADAR) orthologs are believed to lack A-to-I editing, which is the most prevalent editing of mRNA in animals. However, during this study with PUK1 (FGRRES_01058) pseudokinase gene important for sexual reproduction Fusarium graminearum , we found that two tandem stop codons, UA 1831 GUA 1834 G, its kinase domain were changed UG GUG G by perithecia. To confirm transcripts, strand-specific RNA-seq data generated isolated...
Post-transcriptional RNA modifications critically regulate various biological processes. N4-acetylcytidine (ac4C) is an epi-transcriptome, which highly conserved in all species. However, the vivo physiological functions and regulatory mechanisms of ac4C remain poorly understood, particularly mammals. In this study, we demonstrate that only known writer, N-acetyltransferase 10 (NAT10), plays essential role male reproduction. We identified occurrence mRNAs mouse tissues showed undergoes...
RNA N4-acetylcytidine (ac4C) modification is increasingly recognized as an important layer of gene regulation; however, the involvement ac4C in pain regulation has not been studied. Here, we report that N-acetyltransferase 10 protein (NAT10; only known "writer") contributes to induction and development neuropathic ac4C-dependent manner. Peripheral nerve injury increases levels NAT10 expression overall injured dorsal root ganglia (DRGs). This upregulation triggered by activation upstream...
VEGF is believed to be a master regulator in both developmental and pathological angiogenesis.The role of PDGF-C angiogenesis, however, only at the beginning being revealed.We others have shown that critical player angiogenesis because its pleiotropic effects on multiple cellular targets.The angiogenic pathways induced by are, large extent, VEGF-independent.These may include, but not limited to, direct effect vascular cells, tissue stroma fibroblasts, macrophages.Taken together, pleiotropic,...
In petunia, the production of volatile benzenoids/phenylpropanoids determines floral aroma, highly regulated by development, rhythm and ethylene. Previous studies identified several R2R3-type MYB trans-factors as positive regulators scent biosynthesis in petunia flowers. Ethylene response factors (ERFs) have been shown to take part signal transduction hormones, regulation metabolism development processes various plant species. Using virus-induced gene silencing technology, a negative...
Despite continuous expansion of the RNA binding protein (RBP) world, there is a lack systematic understanding RBPs in mammalian testis, which harbors one most complex tissue transcriptomes. We adapted interactome capture to mouse male germ cells, building an RBP atlas characterized by multiple layers dynamics along spermatogenesis. Trapping RNA-cross-linked peptides showed that glutamic acid-arginine (ER) patch, residue-coevolved polyampholytic element present coiled coils, enhances its host...
Meiosis entry during spermatogenesis requires reprogramming from mitotic to meiotic gene expression profiles. Transcriptional regulation has been extensively studied in meiosis entry, but gain of function for master transcription factors is insufficient down-regulate genes. RNA helicase YTHDC2 and its partner MEIOC emerge as essential posttranscriptional regulators entry. However, it unclear what governs the binding specificity YTHDC2/MEIOC. Here, we identified protein RBM46 a component...
Natrinema sp. J7-2 is an extreme haloarchaeon capable of growing on synthetic media without amino acid supplements. Here we report the complete genome sequence which composed a 3,697,626-bp chromosome and 95,989-bp plasmid pJ7-I. This first member genus Natrinema. We demonstrate that can use gluconate, glycerol, or acetate as sole carbon source its encodes metabolic pathways for assimilating these substrates. The biosynthetic all 20 acids have been reconstructed, discuss possible...
Tumor derived vascular endothelial growth factor (VEGF) can stimulate proliferation and migration of cells recruit progenitor into tumors for formation via a paracrine manner. Now increasing evidence suggests that VEGF also serves as an autocrine promoting cell survival tumor angiogenesis. Real time visualization activity in the early stages using molecular imaging will provide unprecedented insight biological processes cancer.The mouse breast cancer line 4T1 was transfected with inducible,...
Although p21 activated kinase 5 (PAK5) is related to the progression of multiple cancers, its biological function in breast cancer remains unclear.Apoptosis-inducing factor (AIF) a vital apoptosis mitochondria, which can be released from mitochondria and enter nucleus, causing caspase-independent apoptosis.In this study, we reveal that PAK5 inhibits by preventing nuclear translocation AIF.PAK5 release AIF cells decreasing membrane permeability increasing potential.Furthermore, phosphorylates...
The O-antigen is a part of the lipopolysaccharide molecule present in outer membrane Gram-negative bacteria, and essential for full function microorganisms. Salmonella enterica Escherichia coli are taxonomically closely related species. In this study, structures S. O16 O38 E. O11 were determined. O21 found to have identical structures, whereas had differing only presence lateral glucose residue O-acetylation mannose former. gene clusters sequenced analyzed together with that retrieved from...
Objective. Breast invasive carcinoma (BRCA), as a systemic disease, is currently the most malignant tumor among women. Early detection of BRCA will increase probability cure. Pyrimidine metabolism (PyM) stands for an essential metabolic pathway related to DNA replication cancer cells, which may also serve diagnostic marker and therapeutic target. Therefore, aim this research discover prognostic signature associated with PyM BRCA. Methods. The mRNA sequencing data along microarray were...
The Hedgehog pathway was recently shown to be involved in vascular development and neovascularization human embryogenesis disease. However, the role of modulating tumor angiogenesis is still unexplored. In current study, we investigated expression Indian (Ihh) endothelial cell growth factor (VEGF) hepatocellular carcinomas (HCCs) with immunohistochemical staining compared immunoreaction data various clinicopathologic characteristics. Immunoreactivity Ihh VEGF proteins observed 61.5% (56/91)...
Abstract Background Pancreatic cancer remains one of the deadliest cancers worldwide. The tumor microenvironment is closely related to occurrence, growth, and metastasis tumors. Collagen type XI alpha 1 chain (COL11A1), as a component extracellular collagen, has been proven be responsible for development drug resistance in various cancers. However, it’s role pancreatic unknown. Method GEPIA (Gene Expression Profiling Interactive Analysis) web tool was used clarify differential expression...
Abstract Background: Despite the high number of researches on pancreatic adenocarcinoma (PAAD) over past decades, little progress had been made due to lack effective treatment regimens. we aimed investigate expression level, mutation, and clinical significance Frizzled (FZD) family in PAAD so as establish a sufficient scientific evidence for decisions risk management. Methods: samples were extracted from The Cancer Genome Atlas (TCGA). Oncomine, Gene profiling interactive analysis (GEPIA),...
Post-weaning diarrhea caused by enterotoxigenic Escherichia coli F18 (E. F18) causes significant economic losses for pig producers. N6-methyladenosine (m6A) is a highly abundant epitranscriptomic marker that has been found to be involved in regulating the resistance of host cells pathogenic infection, but its potential role E. F18-exposed intestinal porcine epithelial (IPEC-J2) remains undetermined. Here, we demonstrated m6A and regulators modulate susceptibility. Briefly, revealed Wilms'...