A5031767034- Cardiac Valve Diseases and Treatments
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Cardiovascular Function and Risk Factors
- Pharmacogenetics and Drug Metabolism
- Aortic Disease and Treatment Approaches
- Acute Myocardial Infarction Research
- Cardiac Imaging and Diagnostics
- Salmonella and Campylobacter epidemiology
- MicroRNA in disease regulation
- Cancer Genomics and Diagnostics
- Natural product bioactivities and synthesis
- Cardiac Structural Anomalies and Repair
- Cardiac pacing and defibrillation studies
- Cardiac electrophysiology and arrhythmias
- Cardiovascular and exercise physiology
- Lung Cancer Treatments and Mutations
- Ginseng Biological Effects and Applications
- Autoimmune Neurological Disorders and Treatments
- Chemotherapy-induced cardiotoxicity and mitigation
- Helicobacter pylori-related gastroenterology studies
- Heart Rate Variability and Autonomic Control
- Pharmacological Effects of Natural Compounds
- Cardiac Arrhythmias and Treatments
- Pancreatic and Hepatic Oncology Research
Shenyang Pharmaceutical University
2002-2025
Anyang Eye Hospital
2025
Fuyang Normal University
2024
Guangzhou University
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2005-2024
Jilin University
2015-2024
Beijing Friendship Hospital
2024
Capital Medical University
2024
Tianjin Medical University Cancer Institute and Hospital
2024
Chongqing Cancer Hospital
2024
The purposes of this study were to investigate how efflux transporters and UDP-glucuronosyltransferases (UGT) affect the disposition naringenin. A rat intestinal perfusion model with bile duct cannulation was used along liver microsomes. In model, both absorption subsequent excretion naringenin metabolites rapid site-dependent (p < 0.05). Naringenin absorbed most in colon, its glucuronides excreted duodenum. metabolism studies, intrinsic clearance value glucuronidation highest jejunum...
This study aimed to investigate the prevalence of diabetes in valvular heart disease (VHD), as well relationship with severity lesions and clinical outcome. A total 11,862 patients significant (≥moderate) VHD from China Valvular Heart Disease were included analysis. The primary outcome was composite all-cause death, hospitalization for failure, myocardial infarction during two-year follow-up. 14.5% (1,721/11,862) VHD. After adjusting patients' demographics, associated a significantly lower...
The roots/rhizomes of Cimicifuga racemosa L. (Nutt.) (black cohosh) have traditionally been used to treat menopausal symptoms through an unknown mechanism action. In effort determine if black cohosh had additional health benefits, methanol extracts were investigated for their potential scavenge reactive oxygen species and protect against menadione-induced DNA damage. These effectively scavenged 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radicals. addition, the showed dose-dependent decreases...
Traditional Chinese exercises (TCEs) have great value in the prevention and effective treatment of cardiovascular diseases (CVD). Our purpose this study was to summarize present research trends future directions regarding link between TCEs CVD by bibliometrics analysis. We searched Web Science Core Collection (WoSCC) for all original articles reviews on published English before August 7, 2022 using CiteSpace 5.8.R3 Microsoft Excel 2019 software, we displayed results form network maps, line...
Abstract Background Programmed cell death 6 (PDCD6) beside its known proapoptotic functions may be a player in survival pathways cancer. The purpose of this study is to further explore the roles PDCD6 epithelial ovarian Methods Lentiviral vector with shRNA for was used investigate effects knockdown on growth, cycle, apoptosis and motility cancer cells. Two hundred twelve tissues were analyzed mRNA expression using RT-PCR. Associations clinical pathological factors, progression free overall...
To study the anticancer mechanism of polyphyllin I (PPI), a Traditional Chinese Medicine, on ovarian cancer cell line HO-8910PM in vitro. Transwell chamber invasive assays were used to investigate inhibitory capacity PPI metastasis. Gene expression profiling chips was screen differentially expressed genes between experiment group and control group. Reverse transcription PCR Western blotting determine mRNA protein levels. With increasing concentration, metastatic cells decreased, with...
Astragaloside IV (ASIV) is a typical bioactive constituent of Radix Astragali. The study aimed to investigate the enterohepatic circulation ASIV and evaluate impact activity intestinal microbiota on deposition ASIV. amounts its metabolites were quantified by an LC-MS/MS method. was metabolized bacteria form brachyoside B (Bra B), cyclogaleginoside (Cyc cycloastragenol (CA), iso-cycloastragenol (iso-CA), dehydrogenated metabolite CA (CA-2H). iso-CA circulated in blood besides when rats...
Thyroid hormones (THs) have profound effects on cardiovascular functions, suggesting that THs may contribute to the development of elevated blood pressure (BP). Few studies, however, systematically assessed relationship between and BP. We therefore conducted a cross‐sectional study examine how serum concentrations are related prevalence BP in euthyroid population. This (n = 12 487) was performed Tianjin, China. Serum free triiodothyronine (FT3), thyroxine (FT4), thyroid‐stimulating hormone...
Polyphyllin I (PPI) is an active component in Rhizoma Paridis, which displays extensive pharmacological antitumor activities. In a previous study, we found that polyphyllin exhibited inhibitory effects on cell growth the human ovarian cancer HO-8910PM line, as well promoting apoptosis and inhibition of migration. Furthermore, gene expression was also profiled by microarray, showed numerous genes were altered PPI; three particular note associated with tumor progression, namely, Caspase-9,...
Purpose: Elevated blood glucose levels may disrupt tear film and meibomian gland function, contributing to dry eye disease (DED) dysfunction (MGD). This study aimed explore the relationship between hyperglycemia DED parameters. Methods: A cross-sectional at Chifeng Chaoju Eye Hospital (June–August 2024) included 56 participants with symptoms. Tear meniscus height (TMH), non-invasive breakup time (FNIBUT, ANIBUT), bulbar redness, atrophy (U-LAMG, L-LAMG) were assessed using a ocular surface...