A5062384537- Gastric Cancer Management and Outcomes
- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- Colorectal Cancer Surgical Treatments
- Colorectal and Anal Carcinomas
- Cancer-related molecular mechanisms research
- Cancer-related Molecular Pathways
- Gastrointestinal Tumor Research and Treatment
- PI3K/AKT/mTOR signaling in cancer
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Colorectal Cancer Treatments and Studies
- Esophageal and GI Pathology
- Gallbladder and Bile Duct Disorders
- Histone Deacetylase Inhibitors Research
- MicroRNA in disease regulation
- Animal Virus Infections Studies
- Viral gastroenteritis research and epidemiology
- Ubiquitin and proteasome pathways
- Cancer Cells and Metastasis
- Epigenetics and DNA Methylation
- Peptidase Inhibition and Analysis
- Metastasis and carcinoma case studies
- Thyroid and Parathyroid Surgery
- Gastrointestinal disorders and treatments
- Circular RNAs in diseases
First Affiliated Hospital of Anhui Medical University
2020-2025
Anhui Medical University
2018-2025
Ruijin Hospital
2008-2024
Henan Provincial People's Hospital
2023-2024
Zhengzhou University
2023-2024
Shanghai Jiao Tong University
2011-2024
Central Hospital of Putuo District
2023-2024
People’s Hospital of Rizhao
2023-2024
Southern Medical University
2024
Union Hospital
2019-2023
Sorafenib, a tyrosine kinase inhibitor, has an important antitumor effect as ferroptosis inducer in multiple cancers, including gastric cancer (GC). However, the status of sorafenib recently been questioned. There is very limited information about relationship between and ATF2, role ATF2 sorafenib-induced not studied. In this study, we investigated underlying molecular mechanisms GC. We found that was significantly upregulated GC tissues predicted poor clinical prognosis. Silencing inhibited...
Several members of the NIMA-related kinase (NEK) family have been implicated in tumor progression; however, role and underlying mechanisms NEK8 gastric cancer (GC) remain unclear. This study revealed a significant upregulation GC, identifying it as an independent prognostic marker patients with GC. Consistent these findings, silencing substantially impeded GC aggressiveness both vitro vivo, while its overexpression produced opposite effect. Gene Ontology enrichment analysis metabolic...
Abstract Histone methylation is a context-dependent modification that regulates gene expression, and the trimethylation of histone H3 lysine 27 (H3K27me3) usually induces silencing. Overcoming colorectal cancer (CRC) chemoresistance currently huge challenge, but relationship between H3K27me3 remains largely unclear. Here, we found levels positively correlated with metastasis-free survival CRC patients low level predicted poor outcome upon chemotherapeutic drug treatment. Oxaliplatin...
Abstract Background Diagnostic biomarkers for the detection of colorectal cancers (CRCs) are lacking. Recent studies have demonstrated that circulating long non-coding RNAs potential to serve as cancers. We analyzed significance lncRNAs 91H, PVT-1 and MEG3 in CRC. Methods examined expression levels 13 candidate plasma 18 CRC patients 20 non-cancerous controls. Then, we validated our findings by determining six promising tissues normal tissues. Finally, evaluated clinical relevance 58 56...
Abstract Background The present study aimed to investigate the expression level, biological function, and underlying mechanism of transmembrane protein 176B (TMEM176B) in gastric cancer (GC). Methods TMEM176B was detected by quantitative real-time polymerase chain reaction (qRT-PCR) western blotting (WB). function determined various vitro assays including colony formation, 5-ethynyl-2ʹ-deoxyuridine (EdU), Transwell, flow cytometry. Bioinformatics techniques were then used elucidate signaling...
To investigate the prediction of pathologic complete response (pCR) in patients with non-small cell lung cancer (NSCLC) undergoing neoadjuvant immunochemotherapy (NAIC) using quantification intratumoral heterogeneity from pre-treatment CT image.
Abstract Transforming growth factor beta (TGF β ) signaling in breast cancer is selectively associated with pulmonary metastasis. However, the underlying mechanisms remain unclear. Here we show that Bcl-3, a member of IκB family, serves as critical regulator TGF to modulate Bcl-3 expression was significantly metastasis-free survival patients. deletion inhibited migration and invasion cells vitro , well lung metastasis vivo . required for downstream genes are involved knockdown enhanced...
The role of activating transcription factor 4 (ATF4) underlying gastric cancer (GC) remains unclear. purpose this study was to investigate the expression levels and biological functions ATF4 in GC.Expression detected by quantitative PCR (qPCR), Western blotting, immunohistochemistry. Cox regression used for survival analysis construction nomogram. Immunofluorescence identify intracellular localization ATF4. Knockdown overexpression GC cells followed wound healing Transwell assays, EdU...
Non-target-site resistance (NTSR) to herbicides is a serious threat global agriculture. Although metabolic the dominant mechanism of NTSR, molecular mechanisms are not yet well-characterized. This study aimed uncover likely metabolism-related genes in Beckmannia syzigachne (American sloughgrass) resistant fenoxaprop-p-ethyl.Ultra-performance liquid chromatography - tandem mass spectrometry experiments showed that American sloughgrass biotype (R, SD-04-SS) enhanced degradation this herbicide...
Wnt/β-catenin signaling plays a critical role in colorectal cancer (CRC) tumorigenesis and the homeostasis of stem cells (CSCs), but its molecular mechanism remains unclear. B-cell lymphoma 3 (Bcl-3), member IκB family, is overexpressed CRC promotes tumorigenicity. Here, we report novel function Bcl-3 maintaining CSC by activating signaling. Silencing suppresses self-renewal capacity CSCs sensitizes to chemotherapeutic drugs through decrease Moreover, our data show that crucial component...
Rab GTPases play a key role in regulating intercellular vesicle trafficking both exo- and endocytic pathways. Recent studies have reported that small the associated regulatory proteins effectors are involved many cancers. The purpose of this study was to investigate biological Rab17 non-small cell lung cancer (NSCLC) relative mechanism.Rab17 expression human NSCLC lines tissues evaluated using real-time PCR (RT-PCR), western blot immunohistochemical (IHC) staining. with RAB17 stable...
Purpose To evaluate laparoscopic gastric resection for gastrointestinal stromal tumors (GIST). Methods From June, 2003 to October, 2009, 56 patients with GIST who underwent were retrospectively reviewed, and their surgical procedure, perioperative outcomes, pathology, follow-up outcomes analyzed. Results All successfully, including 33 wedge resections, 19 transgastric tumor-everting 3 laparoscopic-assisted distal gastrectomies, 1 endoscopic resection. The operative approaches performed...
Objective: To analyze the risk factors of hypoparathyroidism after total thyroidectomy. Methods: Clinical data patients who undergo thyroidectomy in Luwan Branch Ruijin Hospital Affiliated to Medical College Shanghai Jiaotong University was collected from January 2015 December 2018, retrospectively. Logistic regression used associated with transient and long-term hypoparathyroidism. Results: A 537 were collected. The patients' average age included study 47.3 ± 12.7 years old, including 135...
The prognosis of advanced colon adenocarcinoma (COAD) remains poor. However, existing methods are still difficult to assess patient prognosis. Pyroptosis, a lytic and inflammatory process programmed cell death caused by the gasdermin protein, is involved in development progression various tumors. Moreover, there no related studies using pyroptosis-related genes construct model predict COAD patients. Thus, this study, bioinformatics were used analyze data patients downloaded from Cancer...
Objective: The aim of this study was to summary the experiences and lessons from periduodenal perforations related endoscopic retrograde cholangiopancreatography (ERCP) sphincterotomy (EST). Methods: A retrospective review 2004 2007 identified 9 patients (0.37%) perforation ERCP/EST. Charts were reviewed for following parameters: clinical presentation patients, ERCP findings, diagnostic methods, treatment (surgical or conservative procedures), complications, outcome. Results: Nine who had...