A5046643881- Liver Disease Diagnosis and Treatment
- Alcohol Consumption and Health Effects
- Liver Disease and Transplantation
- Diet, Metabolism, and Disease
- Hepatitis C virus research
- Organ Transplantation Techniques and Outcomes
- Substance Abuse Treatment and Outcomes
- Hepatitis B Virus Studies
- Clostridium difficile and Clostridium perfringens research
- Pancreatitis Pathology and Treatment
- Renal Transplantation Outcomes and Treatments
- COVID-19 Clinical Research Studies
- Microscopic Colitis
- Pancreatic and Hepatic Oncology Research
- Hepatitis Viruses Studies and Epidemiology
- Drug-Induced Hepatotoxicity and Protection
- Long-Term Effects of COVID-19
- Nosocomial Infections in ICU
- Clinical Nutrition and Gastroenterology
- Eicosanoids and Hypertension Pharmacology
- Hemophilia Treatment and Research
- Alcoholism and Thiamine Deficiency
- Electrolyte and hormonal disorders
- Patient Satisfaction in Healthcare
- Metabolomics and Mass Spectrometry Studies
Columbia University
2025
Icahn School of Medicine at Mount Sinai
2015-2024
Cedars-Sinai Medical Center
2024
University of Calgary
2024
Mount Sinai Hospital
2014-2022
Xiangya Hospital Central South University
2022
Central South University
2022
Mount Sinai Hospital
2019-2020
Mount Sinai Medical Center
2011-2019
Janssen (United States)
2017
Supported by the American Association for Study of Liver Diseases. Potential conflict interest: Dr. Lucey received grants from Gilead, AbbVie and Pharmasolutions. Szabo consults Allergan. She Terra Firma, Glympse, Quest, Arrow, GLG, Salix Tobira. Genfit, Intercept, Verlyx, Novartis, SignaBlok Shire. holds intellectual property rights with Up to Date. Purpose Scope Guidance Alcohol‐associated liver disease (ALD) represents a spectrum injury resulting alcohol use, ranging hepatic steatosis...
Early liver transplantation (LT) in European centers reportedly improved survival patients with severe alcoholic hepatitis (AH) not responding to medical therapy. Our aim was determine if a strategy of early LT for AH could be applied successfully the United States. We reviewed 111 at our center from January 2012 2015. The primary end point mortality 6 months or LT, secondary alcohol relapse after LT. Survival compared between those receiving and matched who did not. Using process similar...
The coronavirus disease 2019 (COVID‐19) pandemic has had a tremendous global impact since it began in November of 2019. However, there are concerns that the COVID‐19 will not affect all equally and some populations be particularly vulnerable. Relevant to liver disease, patients with alcohol use disorder (AUD) alcohol‐associated (ALD) may among most severely impacted. reasons for this include being at higher risk severe infection due depressed immune system high‐risk underlying comorbidities,...
Early liver transplant (LT) for alcohol-associated disease (i.e., without a specific sobriety period) is controversial but increasingly used. Using the multicenter American Consortium of Liver Transplantation Alcoholic Hepatitis (ACCELERATE-AH) cohort, we aimed to develop predictive tool identify patients pretransplant with low risk sustained alcohol use posttransplant inform selection candidates early LT. We included consecutive ACCELERATE-AH LT recipients between 2012 and 2017. All had...
Liver transplantation (LT) for alcohol associated hepatitis (AH) remains controversial. We convened a consensus conference to examine various aspects of LT AH. The goal was not unequivocally endorse AH; instead, it propose recommendations programs that perform or plan Criteria were established determine candidacy in the setting AH and included following: (1) patients presenting first time with decompensated liver disease are nonresponders medical therapy without severe psychiatric...
Abstract Alcohol use is the most important determinant of development alcohol‐associated liver disease (ALD) and predicting long‐term outcomes in those with established disease. Worldwide, amount, type, pattern alcohol vary. consequent have been increasing certain ethnic groups especially Hispanics Native Americans, likely due to variations genetics, cultural background, socio‐economic status, access health care. Furthermore, magnitude burden ALD last few years among females young adults who...
Early liver transplantation (LT) for alcohol-associated hepatitis (AH) is the fastest growing indication LT, but prediction of harmful alcohol use post-LT remains limited. Among 10 ACCELERATE-AH centers, we examined psychosocial evaluations from consecutive LT recipients AH 2006 to 2017. A multidisciplinary panel used content analysis develop a maximal list variables. We developed an artificial intelligence model predict use. The cohort included training (N = 91 among 8 centers) and external...
Experts have forewarned about the coronavirus disease 2019 (COVID-19) pandemic environment fomenting rising incidence of alcohol use disorder (AUD) and alcohol-associated liver (ALD). We performed a cross-sectional study ALD at our transplantation (LT) center, located in initial U.S. epicenter, New York City. Centered around "stay home" order date state, March 22, 2020, we defined three time periods: "pre-COVID" (January 1, 2020-March 21, 2020), "COVID-quarantine" (March 2020-April...
<h2>Abstract</h2><h3>Background</h3> Alcohol and obesity synergise to increase the risk of liver-related mortality. We examined influence adiposity on clinical outcomes in alcoholic hepatitis (AH) underlying inflammatory crosstalk between adipose tissue (AT) liver. <h3>Methods</h3> A cohort 233 patients with AH from UK USA provided data analyse effects AH. Body mass index was corrected for severity ascites, termed cBMI. Inflammatory metabolic profiling undertaken by proteome analysis human...
Lucey, Michael Ronan; Im, Gene Y.; Mellinger, Jessica L.; Szabo, Gyongyi; Crabb, David W. Author Information
Alcohol‐associated liver disease (ALD) can be coded in United Network for Organ Sharing (UNOS) as either alcoholic cirrhosis or hepatitis (AH), without having specific criteria to assign diagnosis. In this multicenter American Consortium of Early Liver Transplantation Alcoholic Hepatitis (ACCELERATE‐AH) study, we sought assess the concordance clinician diagnosis AH at transplantation (LT) listing versus UNOS data entry a prior consecutive early LT recipients transplanted between 2012 and...
INTRODUCTION: In the published studies of early liver transplantation (LT) for alcohol-associated hepatitis (AH), patients with a prior decompensation are excluded. The appropriateness this criteria is unknown. Methods: Among 6 American Consortium Early Liver Transplantation Alcohol-Associated Hepatitis sites, we included consecutive LT clinically diagnosed AH between 2007 and 2020. Patients were stratified as first vs history decompensation, latter defined diagnosis ascites, hepatic...