A5043739474- Mechanisms of cancer metastasis
- FOXO transcription factor regulation
- Ferroptosis and cancer prognosis
- Gastric Cancer Management and Outcomes
- Epigenetics and DNA Methylation
- Colorectal Cancer Surgical Treatments
- Cancer, Lipids, and Metabolism
- Cancer Genomics and Diagnostics
- Gastroesophageal reflux and treatments
- Colorectal Cancer Treatments and Studies
- Polyamine Metabolism and Applications
- Cancer Mechanisms and Therapy
- Cancer Cells and Metastasis
- Gastrointestinal disorders and treatments
- Protein Kinase Regulation and GTPase Signaling
- Metastasis and carcinoma case studies
- Esophageal and GI Pathology
- Gastrointestinal Tumor Research and Treatment
- RNA modifications and cancer
- Eosinophilic Esophagitis
- Berberine and alkaloids research
- ATP Synthase and ATPases Research
- Artificial Intelligence in Healthcare and Education
- Digestive system and related health
- Galectins and Cancer Biology
Ruijin Hospital
2019-2023
Shanghai Jiao Tong University
2019-2023
Xinjiang Medical University
2015-2018
People's Hospital of Xinjiang Uygur Autonomous Region
2018
Colorectal cancer (CRC) is one of the most common malignant tumors in world. Ferroptosis a newly defined form cell death, distinguished by different morphology, biochemistry, and genetics, involved CRC progression treatment. This study aims to establish predictive model elucidate relationship between ferroptosis prognosis patients, explore potential value therapeutic options.The ferroptosis-related genes were obtained from GeneCards FerrDb websites. The limma R package was used screen...
Gastric cancer is a highly malignant tumor with poor survival rate. Ferroptosis, newly defined regulated cell death, closely related to several tumors. Introduction of ferroptosis promising for treatments. However, the predictive role in GC remains elusive. In this study, we screened ferroptosis-related genes which were differentially expressed between normal and tissues. Then, based on these (DEGs), least absolute shrinkage selection operator (LASSO) multivariate Cox regressions applied...
N-myc downstream-regulated gene 1 (NDRG1) has been shown to play a key role in tumor metastasis. Recent studies demonstrate that NDRG1 can suppress growth and is related proliferation; however, the mechanisms underlying these effects remain obscure.Immunohistochemistry (IHC) was used detect p21 protein expression colorectal cancer tissue, clinical significance of also analyzed. CCK-8 assay, colony formation flow cytometry, xenograft model were assess effect on proliferation vivo vitro. The...
Kaempferol (KF), a flavonoid compound isolated from herbal medicines, has been reported to play significant role in inhibiting certain types of cancer. Although recent studies that KF exerted inhibitive activity on liver cancer, they failed elucidate the signaling pathways and synergistic effects combination with chemotherapeutic drugs currently use clinical setting. In present study, cancer cells were investigated. Nine cell lines used assess KF. Cellular behavioral experiments, such as...
Abstract N-myc downstream-regulated gene 1 (NDRG1) is a key regulator that interacts with many classic tumor signaling pathways, including some molecules downstream of the epidermal growth factor receptor (EGFR). However, whether NDRG1 involved in mechanism resistance to cetuximab (CTX), first monoclonal antibody targeting EGFR has not been reported. Here, we found enhanced sensitivity CTX colorectal cancer (CRC) cell lines. Afterwards, determined underlying this phenomenon. We demonstrated...
N-myc downstream regulated gene-1 (NDRG1) has been identified as a putative metastasis suppressor gene and proved to be key player in cancer spreading proliferation our previous work. However, the effects of NDRG1 on tumor invasion mechanisms behind it are rarely understood. Here we provided silico evidence that plays crucial role actin reorganization colorectal (CRC). Through vitro experiments, next observed filopodia formation was altered NDRG1-modified cell lines, while division cycle-42...
Personalized and novel evidence-based clinical treatment strategy consulting for colorectal cancer has been available through various artificial intelligence (AI) supporting systems such as Watson Oncology (WFO) from IBM. However, the potential effects of this tool in care have not thoroughly explored real-world studies. This research aims to investigate concordance between recommendations patients made by WFO a multidisciplinary team (MDT) at major comprehensive gastrointestinal center. In...
Prefoldin subunits (PFDN), primarily known for co-chaperone function associated with cytoskeletal rearrangement, have been found involved in epithelial-mesenchymal transition (EMT) and cancer progression. However, studies focusing on the roles of PFDN gastric (GC) remain limited. The present study aims to evaluate prognostic values GC. Prognostic PFDNs were analyzed via Kaplan-Meier platform, followed by subset analysis within various clinical parameters. High mRNA expression PFDN2, PFDN3...
Abstract Background Changes in Polyamine metabolism (PAM) have been shown to establish a suppressive tumor microenvironment (TME) and substantially influence the progression of cancer recent studies. However, newly emerging data still unable fully illuminate specific effects PAM human cancers. Here, we analyzed expression profiles clinical relevance genes colorectal (CRC). Methods Based on unsupervised consensus clustering principal component analysis (PCA) algorithm, designed scoring model...
Robotic surgery has been widely adopted for colorectal cancer (CRC). Many surgeons in China have completed structured training programs and performed robotic surgeries. This multicenter study aimed to evaluate the effects of curricula with different laparoscopic experiences during their initial implementation surgery.Ten from five high-volume centers participated this retrospective study. The baseline characteristics, perioperative data, pathological outcomes were compared between first 15...
Colorectal cancer (CRC) is the third cause of expected deaths both in men and women U.S. most commonly diagnosed China Targeted therapy has been proven to improve overall survival for unresectable metastatic CRC. But location primary tumor or presence various core driver gene mutations that confer resistance may limit utility targeted therapy. Therefore, it great significance further elucidate novel mechanisms invasion metastasis CRC find potential therapeutic targets. Protein Kinase C Delta...
Abstract Background The mTOR signaling pathway plays an important role in cancer. As a master regulator, the status of MTOR affects activity and efficacy inhibitor therapy. However, little research has been performed to explore colorectal cancer (CRC). Methods In this study, gene expression clinical data were analyzed using Cancer Genome Atlas (TCGA) Gene Expression Omnibus (GEO) databases. Signaling pathways related CRC identified by Ontology (GO), Kyoto Encyclopedia Genes Genomes (KEGG),...
Introduction: Metabolic dysregulation is a widely acknowledged contributor for the development and tumorigenesis of colorectal cancer (CRC), highlighting need reliable prognostic biomarkers in this malignancy. Methods: Herein, we identified key genes relevant to CRC metabolism through comprehensive analysis lactate metabolism-related from GSEA MsigDB, employing univariate Cox regression random forest algorithms. Clinical was performed following identification three genes, consistent...
Transanal total mesorectal excision (TaTME) is an alternative for mid-low rectal cancer. In China, this procedure has been performed in high-volume centers with structured training curriculums. The efficacy of the TaTME curriculums China still unclear. This multicenter study aimed to explore effectiveness China.Seven participated study. first 25 patients who underwent each center were enrolled. cohort, divided into 3 groups. 5 procedures (group 1) under proctoring according requirement...
Colorectal cancer (CRC) is one of the most common malignant tumors with a high incidence rate and mortality. LncRNA an important regulator immune system. It great significance to study immune-related lncRNAs (IR-lncRNAs) for CRC. In this study, we screened IR-lncRNAs differentially expressed in normal CRC tissues, Univariate Cox regression Least Absolute Shrinkage Selection Operator were applied construct IR-lncRNA prognostic signature TCGA training dataset, its predictive capability...
Abstract Background Changes of Polyamine metabolism (PAM) have been shown to establish a suppressive tumor microenvironment (TME) and substantially influence the progression cancer in recent studies. However, newly emerging data were still unable fully illuminate specific effects PAM human cancers. Here, we analyzed expression profiles clinical relevance genes CRC. Methods Based on unsupervised consistent clustering PCA algorithm, designed scoring model evaluate prognosis CRC patients...
Objective To discuss the diet induced obesity(DIO)on gastroesophageal changes in mice for investigating role of obesity pathogenesis reflux disease, and provide with simple effective experimental basis. Methods 16 male KunMing were randomly divided into two groups which are DIO normal control(NC)group using Microsoft Office Exel.Mice group given to high-fat diet, while NC was diet.After 8 weeks experiment, glucose tolerance test(GTT)and insulin test(ITT)were performed firstly,...
Objective To investigate the expression of IL-4, IL-6 in Barrett esophagus (BE), erosive esophagitis (EE) and nonerosive reflux disease (NERD) role they played gastroesophageal (GERD). Methods Patients BE, EE, NERD control group were carefully selected according to results GERD Questionnaire endoscopy. 24-hour ambulatory esophageal pH monitoring was used estimate patients' acid exposure. Esophageal biopsies taken at endoscopy all four groups observed microscopy for histopathology,...
Objective To discuss the effect of chronic restraint stress(CRS)on gastroesophageal histological changes in mice for investigating role psychological factor pathogenesis reflux disease, and provide with referential parameters successful establishment CRS model. Methods 20male KunMing were randomly divided into two groups which are normal control(NC)group.Mice group submitted to partial stress 2 h per day.After 14 days stress, glucose tolerance test(GTT)and insulin test(ITT)were...
Laparoscopic surgery has been honored as a milestone of the modern in last two decades, especially treatment gastric cancer. The concept minimally invasive now is more concerned about preservation physiological functions, well technical standardization and radical cure Reconstruction procedures, key factor laparoscopic gastrectomy, plays crucial role postoperative organ function. Hence, we review some traditional emerging reconstruction methods their impact on gastroesophageal...