A5102900633- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Occupational and environmental lung diseases
- MicroRNA in disease regulation
- Ultrasound Imaging and Elastography
- Ultrasound and Hyperthermia Applications
- Lymphatic Disorders and Treatments
- Autophagy in Disease and Therapy
- Pelvic and Acetabular Injuries
- Cancer-related molecular mechanisms research
- Lymphatic System and Diseases
- Hernia repair and management
- Circular RNAs in diseases
- Epigenetics and DNA Methylation
- Appendicitis Diagnosis and Management
- Cardiac Health and Mental Health
- Mechanisms of cancer metastasis
- Advanced Image Processing Techniques
- S100 Proteins and Annexins
- Protease and Inhibitor Mechanisms
- Image and Signal Denoising Methods
- Gut microbiota and health
- Galectins and Cancer Biology
- Cancer Immunotherapy and Biomarkers
- Neonatal Respiratory Health Research
- Cancer Mechanisms and Therapy
Beihang University
2025
Tiangong University
2025
North China University of Science and Technology
2011-2024
First Affiliated Hospital of Henan University
2022-2024
Hebei North University
2021-2024
Hebei Medical University
2023
Xingtai People's Hospital
2023
Henan University
2023
Henan University of Traditional Chinese Medicine
2023
Shanghai Pulmonary Hospital
2023
This paper presents a novel speckle suppression method for medical B-scan ultrasonic images. An original image is first separated into two parts with an adaptive filter. These are then transformed multiscale wavelet domain and the coefficients processed by soft thresholding method, which variation of Donoho's (1995) method. The each part back space domain. Finally, denoised obtained as sum parts. A computer-simulated in vitro pig heart have been used to test performance this new technique...
Silicosis is a refractory pneumoconiosis of unknown etiology that characterized by diffuse lung fibrosis, and microRNA (miRNA) dysregulation connected to silicosis. Emerging evidence suggests miRNAs modulate pulmonary fibrosis through autophagy; however, its underlying molecular mechanism remains unclear. In agreement with miRNA microarray analysis, the qRT-PCR results showed miR-29a-3p was significantly decreased in model both vitro vivo. Increased autophagosome observed via transmission...
Abstract Silicosis is a common occupational disease and represents significant contributor to respiratory morbidity mortality worldwide. Lipid-laden macrophages, or foam cells, are observed in the lungs of patients with silicosis but mechanisms mediating their formation remain poorly understood. In this study, we sought elucidate by which silica promotes cell lung, determine whether uptake lipids alone sufficient drive TGF-β production alveolar macrophages. Consistent previous reports, found...
N-myc downstream-regulated gene 1 (NDRG1) has been shown to play a key role in tumor metastasis. Recent studies demonstrate that NDRG1 can suppress growth and is related proliferation; however, the mechanisms underlying these effects remain obscure.Immunohistochemistry (IHC) was used detect p21 protein expression colorectal cancer tissue, clinical significance of also analyzed. CCK-8 assay, colony formation flow cytometry, xenograft model were assess effect on proliferation vivo vitro. The...
Abstract Silicosis is a well‐acknowledged occupational lung disease caused by inhalation of large amount free silica dust during the production period and eventually considerable negative impact on patients' quality life. Autophagy exerts critical influence immune inflammatory responses pathogenesis pulmonary fibrosis. In this study, we sought to determine whether autophagy involved in silicosis's how it may affect cellular physiology. animal experiments, found persistent activation...
Silicosis is a refractory disease. Previous studies indicate that damaged alveolar epithelial cells act as driver in pulmonary fibrosis. Our results show acquire the mesenchymal phenotype are associated with pathogenesis of silicosis. c-Src kinase, non-receptor tyrosine has been shown to be positive regulator organ fibrosis, but specific mechanisms remain unclear and rarely researched The activated Phosphatidylinositol-3 kinases/AKT(PI3K/AKT) pathway promotes We aimed determine whether...
Cyclin D1 is a cell cycle machine, sensor of extracellular signals and plays an important role in G1-S phase progression. The human cyclin promoter contains multiple transcription factor binding sites such as AP-1, NF-қB, E2F, Oct-1, so on. functions through the signal transduction pathways converging at to active or inhibit activity regulate Different different time get correct switch. Disorder regulation special stimuli can result out control regulation. Epigenetic modifications DNA...
Reactive oxygen species (ROS) is a normal metabolic product of cellular respiration, but too much ROS can induce cell apoptosis. Here, we used N-acetylcysteine (NAC) to inhibit activity explore the effects NAC on silica-induced pulmonary fibrosis in rats and provide evidence for study mechanism silicosis. 24 adult male Sprague-Dawley weighing 180-220 g were randomly divided into three groups with eight each group. Silicosis model group adopted non-tracheal exposure method disposable...
An efficient strategy for the synthesis of α-hydroxyamino phosphine oxides by hydrophosphinylation nitrones under catalyst-free and water-as-solvent conditions is reported.
The N-myc downstream-regulated gene (NDRG) family, NDRG1-4, has been involved in a wide spectrum of biological functions multiple cancers. However, their prognostic values remain sparse gastric cancer (GC). Therefore, it is crucial to systematically investigate the NDRG family GC.The were evaluated by Kaplan-Meier Plotter and SurvExpress. mRNA was investigated Cancer Genome Atlas (TCGA). Transcription factors (TFs) miRNAs associated with predicted NetworkAnalysis. DNA methylation levels...
Silicosis, a type of lung inflammation and fibrosis caused by long-term inhalation SiO
Mounting evidence in the cancer literature suggests that microRNAs (miRNAs) influence progression of human cells by targeting protein-coding genes. How insulin-like growth factor 1(IGF1) and miR-186-3p contribute to development cervical (CC) remains unclear. This study examined regulatory roles IGF1 CC development.Gene expression levels were determined qRT-PCR. Proliferation, migration, apoptosis normal MTT, Transwell, caspase-3 activity assays, respectively. Dual-luciferase reporter RNA...
What is the central question of this study? are effects antifibrotic peptide acetyl-seryl-aspartyl-lysyl-proline (Ac-SDKP) on angiotensin-converting enzyme 2 (ACE2)-angiotensin-(1-7)-Mas axis during occurrence and progression silicosis? main finding its importance? Ac-SDKP inhibited lung fibrosis in rats exposed to silica by activation ACE2-angiotensin-(1-7)-Mas axis. Angiotensin-(1-7) potentially promotes increasing level meprin α, major synthetase Ac-SDKP. Thus, interaction...
Silicosis is a fibrotic disease caused by long-term inhalation of SiO2 particles that currently has no effective treatment. Earlier studies have suggested pulmonary lymphatic vessels play key role in the transport silica but not address effects altered drainage on silicosis. Here, we investigated impact impaired In past, disorders were established mainly through use VEGF inhibitors. For first time, model disorder ligating thoracic duct rats. Impaired was found to aggravate inflammation and...
Hydroxycamptothecin (HCPT) represents a new generation of anticancer drugs, with almost no side effects when used for the treatment number types cancer. Autophagy is becoming recognized as an important biological mechanism in human cancer, including lung However, involvement autophagy antiproliferative HCPT on cancer remains unclear. In present study, A549 cells, accepted model non-small cell (NSCLC) were employed. It was demonstrated that able to suppress proliferation and induce apoptosis...
Our objective was to investigate the clinical characteristics of laparoscopic repair for groin hernias in female patients.The data 316 patients (341 hernias) who underwent inguinal hernia at Shanghai Minimally Invasive Surgery Center between January 2001 and December 2015 analyzed retrospectively. The operation-related were provide an overview hernias, preferred surgical approach, management round ligament uterus.There 274 transabdominal preperitoneal patch plastic repairs 67 total...
Face hallucination is a super-resolution algorithm specially designed to improve the resolution and quality of low-resolution (LR) input face images. Although deep neural network offers an end-to-end mapping from LR high-resolution (HR) images, most learning-based hallucinations neglect structure prior for To utilize highly structured facial prior, parallel region-based residual (PRDRN) was developed predict missing detailed information accurate image reconstruction. Initially, divided into...
The present study examined the effect of microRNA (miRNA/miR)‑186‑3p and its target gene, minichromosome maintenance complex component 2 (MCM2), on cervical cancer. Cervical cancer tissues corresponding normal were collected from 48 patients bioinformatics analysis was performed to identify differentially expressed genes in TargetScan TarBase used miRNAs, reverse transcription‑quantitative PCR conducted detect evaluate mRNA expression levels. Additionally, MTT 5‑bromo‑2‑deoxyuridine assays...
Silicosis is a progressive and irreversible common occupational disease caused by long-term inhalation of large amount free silica dust. Its pathogenesis complex, the existing prevention treatment methods can not effectively improve silicosis injury. To uncover potential differential genes in silicosis, SiO2-stimulated rats their control original transcriptomic data sets GSE49144, GSE32147 GSE30178 were downloaded for further bioinformatics analysis. We used R packages to extract standardize...
miR-186-3p acts as a tumor suppressor in various cancers. This study aimed to explore the expression levels of and its role cervical cancer. We analyzed effects insulin-like growth factor 1 (IGF1) on proliferation, invasion, apoptosis cancer cells vitro by regulating PI3K/Akt signaling pathway. In tissues cells, was downregulated, IGF1 upregulated. addition, inhibited cell proliferation invasion enhanced cells. Moreover, our results showed that inversely regulated mRNA through direct...
Silicosis is a common occupational disease caused by the long-term inhalation of large amounts silica dust. Lipid metabolism plays an important role in progression silicosis, but its contributing mechanism remains unclear. The aim this study was to investigate differential lipid metabolites and active metabolic pathways silicosis rat lung tissue. We first constructed model, randomly divided 24 male SD rats into control group (C), for 1 week (S1W), 2 weeks (S2W) 4 (S4W) with 6 each group. ml...