A5101458653- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Esophageal Cancer Research and Treatment
- Circular RNAs in diseases
- Gastric Cancer Management and Outcomes
- Metastasis and carcinoma case studies
- Inflammatory Biomarkers in Disease Prognosis
- Traditional Chinese Medicine Studies
- Colorectal Cancer Surgical Treatments
- Venous Thromboembolism Diagnosis and Management
- Intracranial Aneurysms: Treatment and Complications
- Protein Tyrosine Phosphatases
- Endometrial and Cervical Cancer Treatments
- Genomics, phytochemicals, and oxidative stress
- Advanced Glycation End Products research
- Intracerebral and Subarachnoid Hemorrhage Research
- Advanced biosensing and bioanalysis techniques
- Atrial Fibrillation Management and Outcomes
- Kruppel-like factors research
- Transplantation: Methods and Outcomes
- Blood Coagulation and Thrombosis Mechanisms
- Organ and Tissue Transplantation Research
- Biosensors and Analytical Detection
- Surgical Sutures and Adhesives
- Gold and Silver Nanoparticles Synthesis and Applications
Hebei North University
2016-2024
Shenzhen Second People's Hospital
2024
Zhengzhou University
2024
Hubei University
2024
Third People 's Hospital of Liaoyang
2007-2013
Xian Yang Central Hospital
2013
Ling Tung University
2011
Angiopoietin-like protein (ANGPTL) 4 is a key factor in the regulation of lipid and glucose metabolism metabolic diseases. ANGPTL4 highly expressed various cancers, but energy tumours remains to be determined. This study explored role aerobic glycolysis, glutamine consumption fatty acid oxidation nonsmall cell lung cancer (NSCLC) cells. Two NSCLC lines (A549 H1299) were used investigate by tracer techniques with Seahorse XF technology ANGPTLs4 knockdown RNA microarrays specific inhibitors...
Background Anoikis is a form of programmed cell death essential for preventing cancer metastasis. In some solid cancer, anoikis resistance can facilitate tumor progression. However, this phenomenon underexplored in clear-cell renal carcinoma (ccRCC). Methods Using SVM machine learning, we identified core anoikis-related genes (ARGs) from ccRCC patient transcriptomic data. A LASSO Cox regression model stratified patients into risk groups, informing prognostic model. GSVA and ssGSEA assessed...
Mounting evidence in the cancer literature suggests that microRNAs (miRNAs) influence progression of human cells by targeting protein-coding genes. How insulin-like growth factor 1(IGF1) and miR-186-3p contribute to development cervical (CC) remains unclear. This study examined regulatory roles IGF1 CC development.Gene expression levels were determined qRT-PCR. Proliferation, migration, apoptosis normal MTT, Transwell, caspase-3 activity assays, respectively. Dual-luciferase reporter RNA...
Abstract Objectives Metabolic reprogramming is well accepted as a hallmark of cancer. This study aimed to explore the role Kruppel-like factor 2 (KLF2) in aerobic glycolysis and glutamine consumption energy metabolism non-small cell lung cancer (NSCLC) cells. Methods Two different NSCLC cells, A549 NCI-H1299, were used investigate KLF2 by tracer technique transfection. Key findings The results showed that overexpression KLF could inhibit proliferation but had no significant effect on...
D2 lymph node dissection is widely used in laparoscopic radical gastrectomy for gastric cancer, and its efficacy safety are known patients with obesity. Currently, D2+ also applied to certain cancer of later stages. Due the high difficulty surgery, it more challenging perform on There currently limited research surgery obese cancer. The present study aimed retrospectively analyze clinical data undergoing admitted a single gastroenterology department. Patients body mass index ≥25 kg/m² were...
The present study examined the effect of microRNA (miRNA/miR)‑186‑3p and its target gene, minichromosome maintenance complex component 2 (MCM2), on cervical cancer. Cervical cancer tissues corresponding normal were collected from 48 patients bioinformatics analysis was performed to identify differentially expressed genes in TargetScan TarBase used miRNAs, reverse transcription‑quantitative PCR conducted detect evaluate mRNA expression levels. Additionally, MTT 5‑bromo‑2‑deoxyuridine assays...
miR-186-3p acts as a tumor suppressor in various cancers. This study aimed to explore the expression levels of and its role cervical cancer. We analyzed effects insulin-like growth factor 1 (IGF1) on proliferation, invasion, apoptosis cancer cells vitro by regulating PI3K/Akt signaling pathway. In tissues cells, was downregulated, IGF1 upregulated. addition, inhibited cell proliferation invasion enhanced cells. Moreover, our results showed that inversely regulated mRNA through direct...
Abstract Circular RNAs (circRNAs) participate in the progression of human cancers and have been broadly elucidated. Here, we aimed to elucidate roles functional mechanisms hsa_circ_0080608 (circ_0080608) lung cancer. Quantitative real-time PCR (qPCR) was performed assess mRNA expression levels circ_0080608, miR-661, adrenoceptor alpha 1A (ADRA1A). Western blotting measure ADRA1A protein levels. CCK-8, colony formation, Transwell assays were determine effect circ_0080608 on cell proliferation...
Background: To investigate the expression of high mobility group box B-1 (HMGB-1) in patients with colorectal cancer (CRC) and its association clinicopathological features prognosis carcinoma by combining bioinformatics clinical data analysis, to clarify role HMGB-1. examine whether HMGB-1 is related damage intestinal mucosal barrier, then explore potential HMGB-1-dependent mechanisms affecting progression CRC. Methods: CRC datasets GSE12945, GSE17536, GSE17537 from public gene chip database...
Abstract Objective To explore the molecular mechanisms of radiation therapy's effect on brain metastases from breast cancer. Methods The impact therapy metastatic cancer cells was detected using H&E staining, CT scans, and MRI image fusion; with hippocampal avoidance cognitive function treatment efficacy in patients evaluated; mice metastasis were divided into control groups, western blotting conducted to examine effects SHP2, endoplasmic reticulum stress, mitochondrial autophagy,...
Objective To evaluate the clinical application value and significance by comparing effect of three dimensional conformal radiotherapy combined with chemotherapy on locally advanced non-small cell lung cancer. Methods 60 patients cancer treated in our hospital from December 2013 to 2015 were selected as research object.According method random number, divided into control group experimental group, 30 cases each group.The chemotherapy, three-dimensional docetaxel chemotherapy.After...
Background: Postoperative inflammation is a common complication among patients with non-small cell lung cancer (NSCLC). The effectiveness of modified glasgow prognostic score (mGPS) and onodera's nutrition index (OPNI) in predicting early postoperative prognosis such remains unclear.Method: We use the Gene Ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG) enrichment methods to analyse biological functions pathways differentially expressed genes (DEGs). blood samples 120 NSCLC were...
Objective To understand the training effect and discuss psychiatric nurse specialists training′s influence on core competence scientific research ability by investigating working status of with Chinese Nursing Association certification, in order to improve quality experience. Methods 100 nurses who participated from 2010 2014 were chosen random number table method. Surveyed their after status. Results Eighty-eight valid questionnaires recovered. Scores 2.78 ± 0.55, which medium...