A5043232389- Salmonella and Campylobacter epidemiology
- Animal Nutrition and Physiology
- Viral gastroenteritis research and epidemiology
- Immune Response and Inflammation
- Ion channel regulation and function
- Aquaculture disease management and microbiota
- Genetics and Neurodevelopmental Disorders
- Genomics and Rare Diseases
- Pediatric health and respiratory diseases
- Epilepsy research and treatment
- Cellular transport and secretion
- Inflammasome and immune disorders
- Immune Cell Function and Interaction
- Neuroscience and Neuropharmacology Research
- RNA modifications and cancer
- RNA regulation and disease
- Acute Myeloid Leukemia Research
- Epigenetics and DNA Methylation
- Chronic Kidney Disease and Diabetes
- Invertebrate Immune Response Mechanisms
- MicroRNA in disease regulation
- Lymphatic System and Diseases
- Metabolism and Genetic Disorders
- Lymphatic Disorders and Treatments
- Genetic Syndromes and Imprinting
North China University of Science and Technology
2018-2025
First Affiliated Hospital of Guangzhou Medical University
2025
State Key Laboratory of Respiratory Disease
2025
Guangzhou Medical University
2025
Xian Center for Disease Control and Prevention
2025
Xiamen University
2025
Xiangya Hospital Central South University
2019-2024
Central South University
2021-2024
Freie Universität Berlin
2021-2024
Hunan Children's Hospital
2022-2024
Abstract We have isolated a cDNA clone from human activated NK cell-derived library that identifies transcript (NK4) is selectively expressed in lymphocytes. The expression of this increased after activation T cells by mitogens or IL-2 (lymphokine-activated killer cells). levels demonstrated Northern blot analysis increase 12 h activation, remain high for at least 48 h, and require protein synthesis expression. Southern B lymphoblastoid lines derived 18 unrelated individuals reveal variable...
Silicosis is a refractory disease. Previous studies indicate that damaged alveolar epithelial cells act as driver in pulmonary fibrosis. Our results show acquire the mesenchymal phenotype are associated with pathogenesis of silicosis. c-Src kinase, non-receptor tyrosine has been shown to be positive regulator organ fibrosis, but specific mechanisms remain unclear and rarely researched The activated Phosphatidylinositol-3 kinases/AKT(PI3K/AKT) pathway promotes We aimed determine whether...
Recent studies have reported direct antitumor effects of mannose, a natural six-carbon monosaccharide, in the treatment cancer. Herein, we utilized cancer cell lines, animal models, organoids and experimental techniques such as multi-omics cellular experiments to investigate regulatory mannose on NSCLC growth inflammatory microenvironment. We demonstrated that can inhibit growth, infiltration cytokine expression tissue, enhance efficacy immune checkpoint inhibitor both vitro vivo. Orally...
Differentiating between viral and bacterial respiratory tract infections in pediatric patients remains a significant diagnostic challenge, often leading to the overuse of antibiotics. Myxovirus resistance protein A (MxA) has been identified as promising biomarker for infections. This study aimed assess fluctuations blood MxA levels among children with explore differences infections, focusing on clinical implications antibiotic use. We conducted retrospective using enzyme-linked immunosorbent...
Campylobacter jejuni is one of the most common causes acute enteritis worldwide. Chickens are believed to be main reservoir C. jejuni. The role that host genetics play in resistance/susceptibility colonization broilers still not clear. Day-old from 2 parental lines (A and B) their F1 reciprocal crosses (C D) were challenged orally with 105 cfu address determining broilers. Cloacal swabs collected on 6, 10, 13 d postinoculation (dpi), cecal contents cultured for 7 14 dpi. number colonies...
Abstract Objective This study was undertaken to expand the phenotypic and genetic spectrum of CLCN4 ‐related epilepsy investigate genotype–phenotype correlations. Methods We systematically reviewed newly diagnosed previously reported patients with epilepsy. Three novel variants identified in four this were evaluated through silico prediction functional analysis by Western blot, immunofluorescence, electrophysiological measurements. Results Epilepsy 54.55% (24/44) individuals disorders...
Abstract Leucokinins are invertebrate neuropeptides that exhibit myotropic and diuretic activity. Only one leucokinin‐like peptide receptor is known, the lymnokinin from mollusc Lymnaea stagnalis . A cDNA encoding a was cloned Southern cattle tick, Boophilus microplus , pest of world‐wide. This first neuropeptide known Acari second in subfamily G‐protein‐coupled receptors. The deduced amino acid sequence exhibits 40% identity to receptor. transcript present all tick life stages as determined...
Summary Campylobacter jejuni is one of the most common causes human bacterial enteritis worldwide. The molecular mechanisms host responses chickens to C. colonization are not well understood. We have previously found differences in at 7‐days post‐inoculation (pi) between two genetic broiler lines. However, within each line, all birds were colonized by (27.5% line A, and 70% B). Therefore, objective present experiments was further define gene expression non‐colonized line. RNA isolated from...
In previous studies we characterized the innate immune response of 2 parental broiler lines (A and B) compared their resistance against Salmonella, Enterococcus, Campylobacter challenges. all cases, line A was more responsive resistant than B. present study, sought to determine whether this trend also observed following challenge with protozoan parasite Eimeria tenella. 3 separate experiments, 14-d-old chickens from B were challenged orally 15 50 × 10(3) E. tenella oocysts. Birds killed 6 d...
Hyperpolarization-activated cyclic nucleotide-gated (HCN) channel plays a critical role in regulating the resting membrane potential and integrating synaptic transmission. Variants of HCN1 have been recognized as causes epilepsy, mutant channels could act with loss-of-function (LOF), loss- gain-of-function (LOF GOF) (GOF) mechanisms. However, phenotypes pathogenesis HCN1-related epilepsy are still poorly understood. This study enrolled five epileptic cases carrying different variants: two...