A5052021406- Ion channel regulation and function
- Cellular transport and secretion
- Genomics and Rare Diseases
- Ion Transport and Channel Regulation
- Lipid Membrane Structure and Behavior
- Environmental Chemistry and Analysis
- Pain Mechanisms and Treatments
- Genetics and Neurodevelopmental Disorders
- Marine Biology and Environmental Chemistry
- Heavy Metal Exposure and Toxicity
- Oil Palm Production and Sustainability
- Epilepsy research and treatment
- Biofuel production and bioconversion
- Adolescent and Pediatric Healthcare
- Adenosine and Purinergic Signaling
- Mercury impact and mitigation studies
- Plant-based Medicinal Research
- Heavy metals in environment
- Biodiesel Production and Applications
- Neuroscience of respiration and sleep
- Environmental Toxicology and Ecotoxicology
- Microplastics and Plastic Pollution
- Neuroscience and Neuropharmacology Research
Forschungszentrum Jülich
2021-2024
German Center for Lung Research
2024
Ludwig-Maximilians-Universität München
2023-2024
Stadtwerke Jülich (Germany)
2023
University of Cartagena
2017-2018
Abstract Objective This study was undertaken to expand the phenotypic and genetic spectrum of CLCN4 ‐related epilepsy investigate genotype–phenotype correlations. Methods We systematically reviewed newly diagnosed previously reported patients with epilepsy. Three novel variants identified in four this were evaluated through silico prediction functional analysis by Western blot, immunofluorescence, electrophysiological measurements. Results Epilepsy 54.55% (24/44) individuals disorders...
Early/late endosomes, recycling and lysosomes together form the endo-lysosomal pathway. This system plays a crucial role in cell differentiation survival, dysregulation of appears to be important pathogenesis neurodevelopmental neurodegenerative diseases. Each compartment fulfils specific function, which is supported by ion transporters channels that modify concentrations electrical gradients across membranes. CLC-type Cl – /H + exchangers are group assumed regulate luminal acidification...
Abstract Imposex is the development of male sexual characteristics caused by toxic effects some chemicals that acts as an endocrinal disruptor. Antifouling paints contain these chemicals. Cartagena lacks studies to indicate extent imposex in its coastal waters. The aim this study was determine prevalence gastropod Stramonita haemastoma Cartagena, Colombia. Specimens were collected during 2013 from locations high and low influence port activity. Morphometric measurements frequency occurrence...
ClC-3, ClC-4, and ClC-5 are electrogenic chloride/proton exchangers that can be found in endosomal compartments of mammalian cells. Although the association with genetic diseases severe phenotype knock-out animals illustrate their physiological importance, cellular functions these proteins have remained insufficiently understood. We here study role two Clcn3 splice variants, ClC-3b ClC-3c, granular exocytosis catecholamine accumulation adrenal chromaffin cells using a combination...
The objective of this research was to highlight the economic importance optimal use products and byproducts oil palm. In Colombia, productive crops per hectare can generate, over one year, an average 3.14 tons oil, up 21.68 t solid liquid waste when plant is on a stage. These data allowed researcher estimate that more than nine million produced from 450 131 ha present in 2014, Colombia; biomass used generate energy steam, releasing carbon dioxide back again into environment. residues have...
ClC-3 Cl – /H + exchangers are expressed in multiple endosomal compartments and likely modify intra-endosomal pH [Cl ] via the stoichiometrically coupled exchange of two ions one H . We studied pain perception Clcn3 –/– mice found that not only modifies electrical activity peripheral nociceptors but is also involved inflammatory processes spinal cord. demonstrate regulates number Na v K ion channels plasma membrane dorsal root ganglion (DRG) neurons these changes impair age-dependent decline...
Introduction P2X receptors are a family of homo- and heterotrimeric cation channels gated by extracellular ATP. The P2X4 P2X7 subunits show overlapping expression patterns have been involved in similar physiological processes, such as pain inflammation well various immune cell functions. While formation P2X2/P2X3 heterotrimers produces distinct pharmacological phenotype has established, functional identification P2X4/P2X7 heteromer difficult evidence for against physical association found....
Background: Variants in CLCN4 are implicated neurodevelopmental disorder, X-linked intellectual disability, and epileptic encephalopathy. encodes ClC-4, which is hypothesized to play a role ion homeostasis intracellular trafficking. ClC-4 relies on its formation of heterodimers with ClC-3, possesses signals for target organelles. Methods: Case-Series. Then, we performed heterologous expression, patch-clamp electrophysiology, confocal microscopy, protein biochemistry experiments characterize...
<title>Abstract</title> <italic>CLCN4</italic>-related disorder is a rare X-linked neurodevelopmental condition with pathogenic mechanism yet to be elucidated. <italic>CLCN4 </italic>encodes the vesicular 2Cl<sup>-</sup>/H<sup>+</sup> exchanger ClC-4, and <italic>CLCN4</italic> variants frequently result in altered ClC-4 transport activity<italic>. </italic>The precise cellular molecular function of remains unknown; however, together ClC-3, thought have role ion homeostasis endosomes...