A5057019174- Occupational and environmental lung diseases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Medical Imaging and Pathology Studies
- Microtubule and mitosis dynamics
- Inflammasome and immune disorders
- Telomeres, Telomerase, and Senescence
- Dermatologic Treatments and Research
- Plant Physiology and Cultivation Studies
- Protease and Inhibitor Mechanisms
- Bone health and treatments
- Media, Gender, and Advertising
- Occupational exposure and asthma
- Air Quality and Health Impacts
- Various Chemistry Research Topics
- Aluminum toxicity and tolerance in plants and animals
- Genetic and Kidney Cyst Diseases
- Phytochemistry and Biological Activities
- RNA Interference and Gene Delivery
- Cardiac Fibrosis and Remodeling
- Silk-based biomaterials and applications
- Wnt/β-catenin signaling in development and cancer
- Renin-Angiotensin System Studies
- TGF-β signaling in diseases
- Landslides and related hazards
- Competency Development and Evaluation
Hebei Agricultural University
2025
North China University of Science and Technology
2018-2024
First Affiliated Hospital of Nanchang University
2023
Nanchang University
2023
Sun Yat-sen University
2022
Sun Yat-sen Memorial Hospital
2022
Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences
2019
Guiyang Medical University
2019
Chongqing University
2015
Central South University
2014
To identify potential therapeutic targets for pulmonary fibrosis induced by silica, we studied the effects of this disease on expression microRNAs (miRNAs) in lung. Rattus norvegicus silicosis models were used conjunction with high-throughput screening lung specimens to compare miRNAs control and tissues. A total 70 found be differentially expressed between This included 41 that upregulated 29 downregulated relative controls. Among them, miR-292-5p, miR-155-3p, miR-1193-3p, miR-411-3p,...
Quercetin exerts anti-inflammatory, anti-oxidant and other protective effects. Previous studies have shown that senescent cells, such as fibroblasts type II airway epithelial are strongly implicated in the development of pulmonary fibrosis pathology. However, role macrophages during silicosis remains unclear. We investigated effects quercetin on macrophage senescence fibrosis, explored underlying mechanisms. Mice were randomized to six model groups. Vitro was also established by culturing...
Silicosis is a fatal profession-related disease linked to long-term inhalation of silica. The present study aimed determine whether meprin α, master regulator anti-fibrotic peptide N-acetyl-seryl-aspartyl-lysyl-proline (Ac-SDKP), diminished by miR-155-5p in silicotic and control lung macrophages fibroblasts upon activation. NR8383 macrophages, primary fibroblasts, mouse embryonic were used evaluate the expression function α miR-155-5p. In vitro manipulation was performed recombinant protein,...
Glycolytic reprogramming is an important metabolic feature in the development of pulmonary fibrosis. However, specific mechanism glycolysis silicosis still not clear. In this study, silicotic models and silica-induced macrophage were used to elucidate induced by silica. Expression levels key enzymes activation indicators analyzed Western blot, qRT-PCR, IHC, IF analyses, using a lactate assay kit. We found that silica promotes expression HK2, PKM2, LDHA, factors iNOS, TNF-α, Arg-1, IL-10,...
Silica-induced inflammatory activation is associated with silicosis and various non-respiratory conditions. The present study was designed to examine the anti-inflammatory effects of N-acetyl-seryl-aspartyl-lysyl-proline (Ac-SDKP) on lung macrophages bone osteoclasts after silica inhalation in rats.Wistar rats NR8383 RAW 264.7 cell lines were used study. receptor activator nuclear factor kappa-B ligand (RANKL) toll-like 4 (TLR4) signaling pathways measured tissue or NR8383/RAW cells exposed...
The role and molecular mechanism of long non-coding RNA (lncRNA)-related pathways in silicosis have not been elucidated clearly. aims this study were to evaluate the expression lncRNAs during silica-induced pulmonary fibrosis verify function LOC103691771 myofibroblast differentiation induced by transforming growth factor-β1 (TGF-β1). RNA-sequencing was performed assess differential control silicotic rat lungs. Differential analyzed Gene Ontology Kyoto Encyclopedia Genes Genomes identify...
Glycolysis and ER stress have been considered important drivers of pulmonary fibrosis. However, it is not clear whether glycolysis are interconnected if those interconnections regulate the development Our previous studies found that expression LDHA, a key enzyme involved in glycolysis, was increased silica-induced macrophages silicotic models, closely related to silicosis fibrosis by participating inflammatory response. pharmacological inhibition LDHA beneficial amelioration remains unclear....
Endoscopic thoracoscopic sympathectomy (ETS) is the preferred method for treating primary palmar hyperhidrosis (PPH) that bears risk of compensatory (CH) following surgery. The current study aims to evaluate effectiveness and safety an innovative surgical procedure ETS.A survey clinical data 109 patients with PPH who underwent ETS in our department from May 2018 August 2021 was retrospectively conducted. were organized into two groups. Group A R4 sympathicotomy combined R3 ramicotomy. B...
The role and mechanisms of integrated stress response inhibitor (ISRIB) on silicosis are still not well defined. In the present study, effects ISRIB cellular senescence pulmonary fibrosis in were evaluated by RNA sequencing, micro-computed tomography, function assessment, histological examination, Western blot analysis. results showed that significantly reduced degree mice with expression type I collagen, fibronectin, α-smooth muscle actin, transforming growth factor-β1. Both vivo vitro...
What is the central question of this study? are effects antifibrotic peptide acetyl-seryl-aspartyl-lysyl-proline (Ac-SDKP) on angiotensin-converting enzyme 2 (ACE2)-angiotensin-(1-7)-Mas axis during occurrence and progression silicosis? main finding its importance? Ac-SDKP inhibited lung fibrosis in rats exposed to silica by activation ACE2-angiotensin-(1-7)-Mas axis. Angiotensin-(1-7) potentially promotes increasing level meprin α, major synthetase Ac-SDKP. Thus, interaction...
The purpose of this study was to determine the effects Kinesin family member 3A (KIF3A) on primary cilia and myofibroblast differentiation during silicosis by regulating Sonic hedgehog (SHH) signalling.Methods: Changes in were detected silicotic patients, experimental rats, a model induced SiO2.We also explored mechanisms underlying KIF3A regulation Glioma-associated oncogene homologs (GLIs) involved differentiation.Results: Primary (marked ARL13B Ac-α-Tub) ciliary-related proteins (IFT 88...
Abstract Rosacea is a chronic inflammatory skin disorder that can lead to fibrosis. However, the mechanisms underlying fibrosis in later stages of rosacea have been less thoroughly investigated. Interleukin‐17A (IL‐17A) has implicated both inflammation and organ fibrosis; however, effectiveness mechanism IL‐17A‐neutralizing antibodies rosacea‐related remain unclear. In this study, we induced rosacea‐like lesions mice using LL‐37 administered antibodies. The results indicated alleviated...
ABSTRACT Silicosis is characterized by silica exposure-induced lung interstitial fibrosis and formation of silicotic nodules, resulting in stiffening. The acetylation microtubules mediated α-tubulin N-acetyltransferase 1 (α-TAT1) a posttranslational modification that promotes microtubule stability response to mechanical stimulation. α-TAT1 downstream acetylated (Ac-α-Tub) are decreased silicosis, promoting the epithelial–mesenchymal transition (EMT); however, underlying mechanisms unknown....
Cellular senescence has been considered an important driver of many chronic lung diseases. However, the specific mechanism cellular in silicosis is still unknown. In present study, silicotic rats and osteoclast stimulatory transmembrane protein ( Ocstamp ) overexpression MLE‐12 cells were used to explore OC‐STAMP alveolar epithelial cell type II (AEC2). We found increasing level AEC2 rats. Overexpression promoted epithelial‐mesenchymal transition (EMT), endoplasmic reticulum (ER) stress,...
Abstract Skin fibrosis, which is characterized by fibroblast proliferation and increased extracellular matrix, has no effective treatment. An increasing number of studies have shown that microRNAs (miRNAs/miRs) participate in the mechanism skin such as limited cutaneous systemic sclerosis pathological scarring. The objective present study was to determine role miR‐411‐3p bleomycin (BLM)‐induced fibrosis transformation. Using Western blot analysis real‐time quantitative polymerase chain...