A5019472670- Dermatologic Treatments and Research
- Skin and Cellular Biology Research
- Acne and Rosacea Treatments and Effects
- Systemic Sclerosis and Related Diseases
- Dermatology and Skin Diseases
North China University of Science and Technology
2021-2024
Abstract Rosacea is a chronic inflammatory skin disorder that can lead to fibrosis. However, the mechanisms underlying fibrosis in later stages of rosacea have been less thoroughly investigated. Interleukin‐17A (IL‐17A) has implicated both inflammation and organ fibrosis; however, effectiveness mechanism IL‐17A‐neutralizing antibodies rosacea‐related remain unclear. In this study, we induced rosacea‐like lesions mice using LL‐37 administered antibodies. The results indicated alleviated...
Abstract Skin fibrosis, which is characterized by fibroblast proliferation and increased extracellular matrix, has no effective treatment. An increasing number of studies have shown that microRNAs (miRNAs/miRs) participate in the mechanism skin such as limited cutaneous systemic sclerosis pathological scarring. The objective present study was to determine role miR‐411‐3p bleomycin (BLM)‐induced fibrosis transformation. Using Western blot analysis real‐time quantitative polymerase chain...