A5101413203- Pharmacogenetics and Drug Metabolism
- Advanced Neural Network Applications
- Drug Transport and Resistance Mechanisms
- 3D Shape Modeling and Analysis
- Advanced Image and Video Retrieval Techniques
- Medical Research and Treatments
- Caching and Content Delivery
- Face and Expression Recognition
- 3D Surveying and Cultural Heritage
- Privacy-Preserving Technologies in Data
- Advanced MIMO Systems Optimization
- Remote Sensing and LiDAR Applications
- Advanced Graph Neural Networks
- Modular Robots and Swarm Intelligence
- Machine Learning and Data Classification
- Educational Reforms and Innovations
- Analytical Chemistry and Chromatography
- Robotic Path Planning Algorithms
- Domain Adaptation and Few-Shot Learning
- Multimodal Machine Learning Applications
- Service-Oriented Architecture and Web Services
- Eicosanoids and Hypertension Pharmacology
- Remote Sensing and Land Use
- Opportunistic and Delay-Tolerant Networks
- Text and Document Classification Technologies
Beijing Information Science & Technology University
2024
Jiangxi Normal University
2023-2024
Harbin Institute of Technology
2023-2024
Southern University of Science and Technology
2022-2024
Northeastern University
2024
State Key Laboratory of Robotics and Systems
2024
Lanzhou University of Technology
2024
Nanchang Institute of Technology
2023
Tokyo University of Information Sciences
2023
The University of Tokyo
2023
In this work, we introduce FARP-Net, an adaptive local-global feature aggregation and relation-aware proposal network for high-quality 3D object detection from pure point clouds. Our key insight is that learning irregular yet sparse cloud generating superb proposals are both pivotal detection. Technically, propose a novel layer (LGFAL) fully exploits the complementary correlation between local features global features, fuses their strengths adaptively via attention-based fusion module....
In this study, metabolism of bupropion, efavirenz, and 7-ethoxy-4-trifluoromethylcoumarin (7-EFC) by CYP2B6 wild type (CYP2B6.1) six polymorphic variants (CYP2B6.4 to CYP2B6.9) was investigated in a reconstituted system gain better understanding the effects mutations on catalytic properties these naturally occurring variants. All were successfully overexpressed <i>Escherichia coli</i>, including CYP2B6.8 (the K139E variant), which previously could not be mammalian COS-1 cells (<i>J Pharmacol...
As the feature dimension of data continues to expand, task selecting an optimal subset features from a pool limited labeled and extensive unlabeled becomes more challenging. In recent years, some semi-supervised selection methods (SSFS) have been proposed select features, but they still drawbacks limiting their performance, for e.g., many SSFS underutilize structural distribution information available within data. To address this issue, we method based on adaptive graph with global local...
Quercetin exerts anti-inflammatory, anti-oxidant and other protective effects. Previous studies have shown that senescent cells, such as fibroblasts type II airway epithelial are strongly implicated in the development of pulmonary fibrosis pathology. However, role macrophages during silicosis remains unclear. We investigated effects quercetin on macrophage senescence fibrosis, explored underlying mechanisms. Mice were randomized to six model groups. Vitro was also established by culturing...
The architectural advancements in deep neural networks have led to remarkable leap-forwards across a broad array of computer vision tasks. Instead relying on human expertise, architecture search (NAS) has emerged as promising avenue toward automating the design architectures. While recent achievements image classification suggested opportunities, promises NAS yet be thoroughly assessed more challenging tasks semantic segmentation. main challenges applying segmentation arise from two aspects:...
The 3D object detection is becoming indispensable for environmental perception in autonomous driving. Light and ranging (LiDAR) point clouds often fail to distinguish objects with similar structures are quite sparse distant or small objects, thereby introducing false missed detections. To address these issues, LiDAR fused cameras due the rich textural information provided by images. However, current fusion methods suffer inefficient data representation inaccurate alignment of heterogeneous...
We have investigated the mechanisms by which clopidogrel inactivates human cytochrome P450 2B6 (CYP2B6) in a reconstituted system. It was found that and its thiolactone metabolite, 2-oxo-clopidogrel, both inactivate CYP2B6 time- concentration-dependent manner. On basis of <i>k</i><sub>inact</sub>/<i>K</i><sub>I</sub> ratios, is approximately 5 times more efficient than 2-oxo-clopidogrel inactivating CYP2B6. Analysis molecular mass wild-type (WT) protein had been inactivated either or showed...
This study introduces a novel approach, Local Spatial Projection Convolution (LSPConv), for point cloud classification and semantic segmentation. Unlike conventional methods utilizing relative coordinates local geometric information, our motivation stems from the inadequacy of existing techniques representing intricate spatial organization unconsolidated irregular 3D clouds. To address this limitation, we propose Module vector projection strategy, designed to capture comprehensive...
The endocannabinoid system plays an important role in numerous physiological processes including mood, appetite, and pain sensation. A critical compound maintaining cannabinoid tone is the anandamide (AEA). We have recently shown that AEA metabolized by several different human cytochromes P450 (P450) to form a number of metabolites, one which exhibits increased biological activity. CYP3A4, major P450s involved metabolism AEA, produces four metabolites. One these 5,6-epoxyeicosatrienoic acid...
The mechanism-based inactivation of human CYP2B6 by <i>tert</i>-butylphenylacetylene (BPA) in the reconstituted system was investigated. BPA is time-, concentration-, and NADPH-dependent exhibits a <i>K</i><sub>I</sub> 2.8 μM, <i>k</i><sub>inact</sub> 0.7 min<sup>−1</sup>, <i>t</i><sub>1/2</sub> 1 min. partition ratio ∼5. Unlike CYP2B1 CYP2B4, addition to formation an apoprotein adduct glutathione conjugate, small heme observed when incubated with BPA. mass increase adducted GSH conjugate...
Data-plane fault localization enhances network availability and reliability by enabling circumvention of malicious entities on a path. Algorithms for data-plane exist intra-domain settings, however, the per-flow or per-source state required at intermediate routers makes them prohibitively expensive in inter-domain settings. We present Faultprints, first secure protocol that is practical Faultprints enables source to precisely localize links drop, delay, modify packets. implemented an...
Mifepristone [RU486; 17β-hydroxy-11β-(4-dimethylaminophenyl)-17α-(1-propynyl)-estra-4,9-dien-3-one] inactivates CYP2B6 in the reconstituted system a mechanism-based manner. The loss of 7-ethoxy-4-(trifluoromethyl)-coumarin deethylation activity is concentration- and time-dependent. inactivation requires NADPH irreversible. concentration inactivator required to give half-maximal rate 2.8 μM, maximal constant for at saturating 0.07 min<sup>-1</sup>. Incubation with 20 μM RU486 15 min resulted...
The mechanism of inactivation cytochrome P450 2B1 (CYP2B1) by 4-<i>tert</i>-butylphenylacetylene (BPA) has been characterized previously to be caused the covalent binding a reactive intermediate apoprotein rather than heme destruction (<i>J Pharmacol Exp Ther</i><b>331:</b>392–403, 2009). identification BPA-glutathione conjugate and increase in mass BPA-adducted have indicated that adduct is 174 Da, equivalent BPA plus one oxygen atom. To identify adducted residue, BPA-inactivated CYP2B1 was...
Surface temperature of lakes and reservoirs is one the important indicators change on earth's surface, which not only reflects impact climate change, but also has great significance for water resource management ecological environmental protection. However, traditional observation methods are limited by factors such as time, space economic cost, make it difficult to provide comprehensive continuous data. Therefore, quantitative inversion surface using remote sensing technology become hot...
Recently, point-based networks have exhibited extraordinary potential for 3D point cloud processing. However, owing to the meticulous design of both parameters and hyperparameters inside network, constructing a promising network each task can be an expensive endeavor. In this work, we develop novel one-shot search framework called Point-NAS automatically determine optimum architectures various tasks. Specifically, elastic feature extraction (EFE) module that serves as basic unit architecture...
In a device-to-device (D2D) communication underlying cellular network, user equipment is desired to operate cooperatively and unselfishly transmit data as relays. However, most users more or less behave in selfish way, which makes selfishness key factor that affects the performance of whole system. We focus on impact D2D communications. First, we distinguish into two types accordance with transmission modes, namely connected opportunistic modes. The these transmissions are modeled...
The mechanism-based inactivation of cytochrome CYP2B1 [wild type (WT)] and its Thr205 to Ala mutant (T205A) by <i>tert</i>-butylphenylacetylene (BPA) <i>tert</i>-butyl 1-methyl-2-propynyl ether (BMP) in the reconstituted system was investigated. WT BPA exhibited a <i>k</i><sub>inact</sub>/<i>K</i><sub>I</sub> value 1343 min<sup>−1</sup>mM<sup>−1</sup> partition ratio 1. BMP 33 10. Liquid chromatography/tandem mass spectrometry analysis (LC/MS/MS) revealed 1) resulted formation protein adduct...
In a device-to-device (D2D) communication underlaying cellular network, user equipments are required to operate cooperatively and unselfishly transmit data as relays. However, most users behave in more or less selfish way, which makes selfishness key factor that affects the performance of whole system. We focus on impact node D2D communications. By separating into two types accordance with transmission modes - connected opportunistic transmission, we propose time-varying graph model...
NAND flash memory has gained popularity in a wide variety of digital storage systems. Although with excellent performance, suffers various reliability problems. In recent years, researchers try to predict failure by using machine-learning models. However, the application based prediction method faces following problems: imbalance between robustness and portability. When applying on different chips, performance model degrades variation error characteristics. order adapt variation, needs be...
Four mutants of Thr-205 in cytochrome P450 2B1 were constructed and expressed <i>Escherichia coli</i>. The Ser-, Ala-, Val-mutants displayed stable reduced CO difference spectra able to metabolize 7-ethoxy-4-(trifluoromethyl)coumarin, testosterone, androstenedione, benzphetamine. Arg-mutant an unstable spectrum at 450 nm, was concomitantly converted a denatured form with peak 422 showed no catalytic activity any the four substrates tested. Ser-mutant metabolite profiles for testosterone...
We have previously demonstrated that substituting Val for Thr-205 in P450 2B1 abolishes the 16β-hydroxylation of testosterone and markedly decreases ability 2-ethnylnaphthalene (2EN) 17α-ethynylestradiol (17EE) to inactivate 2B1. The role has been further investigated by measuring kinetics mechanism-based inactivation 7-ethoxy-(trifluoromethyl)coumarin deethylation activity 2EN 17EE wild-type (WT) mutant P450s. In general, Ser Ala mutants was not significantly altered compared with WT....