A5052660713- Colorectal Cancer Treatments and Studies
- Gastric Cancer Management and Outcomes
- Diet, Metabolism, and Disease
- Metabolism, Diabetes, and Cancer
- Lung Cancer Research Studies
- Facial Rejuvenation and Surgery Techniques
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Acne and Rosacea Treatments and Effects
- Cancer therapeutics and mechanisms
- Diabetes Management and Research
- Oral Health Pathology and Treatment
- Histiocytic Disorders and Treatments
- Ferroptosis and cancer prognosis
- Gastrointestinal Tumor Research and Treatment
- Pulmonary Hypertension Research and Treatments
- Metabolism and Genetic Disorders
- Neutropenia and Cancer Infections
- Image Retrieval and Classification Techniques
- Neuroendocrine Tumor Research Advances
- Machine Learning in Bioinformatics
- Cancer, Hypoxia, and Metabolism
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Text and Document Classification Technologies
- Digital Imaging in Medicine
- Occupational exposure and asthma
Chinese PLA General Hospital
2021-2025
Chung Shan Medical University Hospital
2024
Chung Shan Medical University
2024
Wannan Medical College
2023
Chinese People's Liberation Army
2022
North China University of Science and Technology
2017-2020
Chinese Academy of Medical Sciences & Peking Union Medical College
2020
National Health and Family Planning Commission
2020
Beijing Institute of Genomics
2013-2017
Chinese Academy of Sciences
2013-2017
Ferroptosis is a newly defined non-apoptotic programmed cell death resulting from the accumulation of lipid peroxides. Whether ferroptosis plays any role in chemotherapy remains to be established. Here, we reported that represents part chemotherapeutic drug etoposide-induced response Small Cell Lung Cancer (SCLC) cells and adaptive signaling molecule lactate protects Non-Small (NSCLC) ferroptosis. Lactate derived metabolic reprogramming increases expression glutathione peroxidase 4 (GPX4)...
Myofibroblasts play a major role in the synthesis of extracellular matrix (ECM) and stimulation these cells is thought to an important development silicosis. The present study was undertaken investigate anti-fibrotic effects dibutyryl-cAMP (db-cAMP) on rats induced by silica. A HOPE MED 8050 exposure control apparatus used create silicosis model. Rats were randomly divided into 4 groups: 1)controls for 16 w; 2)silicosis 3)db-cAMP pre-treatment; 4) db-cAMP post-treatment. Rat pulmonary...
<i>Background/Aims:</i> Insulinoma is a rare and potentially curable disease. It often misdiagnosed as neurological or psychiatric disorder. This study was performed to characterize the neuropsychiatric symptoms (PNS) of patients with insulinoma from regional clinical center. <i>Methods:</i> All medical records histopathologically identified were reviewed during period 1998 2008. A case-control analysis compare demographic data, details presentation, biochemical...
The role of angiotensin-converting enzyme 2 (ACE2) in silicosis remains unknown, although previous studies have suggested that ACE2 may be beneficial. We, therefore, investigated the effect on silicosis, particularly with regard to its regulating epithelial-mesenchymal transition (EMT) induced by silica, aim uncover a new potential target for treatment pulmonary fibrosis.We employed wild-type mice treated diminazene aceturate (DIZE, an activator, 15 mg/kg/day 4 weeks), hACE2-transgenic...
Irinotecan-induced severe neutropenia and diarrhea, which remain unpredictable, has restrained the dose clinical efficiency of irinotecan administration. In present study, a total 70 irinotecan-treated patients with histologically confirmed metastatic gastrointestinal cancer were enrolled. Despite genotyping well‑reported alleles, direct sequencing was specifically adopted to avoid ethnic heterogeneity identify novel variations. The promoter (‑1000 bp) exon 1 regions UDP...
Background and Objectives: In the literature, relationships between being married having prediabetes or diabetes are inconsistent. We aimed to investigate whether marriage is a protective risk factor for uncover new insights into its impact on prediabetes. Materials Methods: this cross-sectional observational study, questionnaires were distributed by email 1,039 staff members who participated in an employee health check from hospital affiliated with medical university Taiwan. Fasting blood...
Gastric cancer (GC) is the second leading cause of cancer-related mortality worldwide. The usual treatment GC consists surgery with additional adjuvant chemotherapy. In present study, feasibility and safety S-1 plus oxaliplatin (SOX) chemotherapy for patients optimal dosage were determined. Eligible randomly assigned to either arm A (30 cases) receiving 70 mg/m2 (in two seperate half doses) daily or B 80 daily. was administered twice 14 days followed by a 7-day rest period third week. total...
Rhinoplasty is becoming increasingly frequent as the pursuit of aesthetics by people accelerates. In recent years, proportion opting for rhinoplasty injections has gradually increased. This led to numerous reports citing catastrophic postoperative complications such skin necrosis, cerebral infarction, and visual impairment.The aim our report discuss possible etiological factors this post-rhinoplasty complication provides a rationale HA injection history risk factor in rhinoplasty.We rare...
The aim of this study was to compare the efficacy, safety and survival rate a treatment regimen comprising capecitabine plus irinotecan (XELIRI) those standard leucovorin, fluorouracil (FOLFIRI), determine correlation among inherited genetic variations in UGT1A1, UGT1A7 UGT1A9. A total 84 consecutive patients with histologically confirmed metastatic colorectal cancer (mCRC) were included study. All treated FOLFIRI or XELIRI. median progression‑free time 4.4 months for 5.7 XELIRI (hazard...
Gastric cancer (GC) is the fourth most common type of cancer, accounting for an estimated one million new cases annually worldwide. Locally advanced GC often recurs, even following curative surgical resection. Therefore, there a need effective adjuvant chemotherapy regimen. The aim this trial was to investigate maximum tolerated dose (MTD) S-1 when administered in combination with oxaliplatin postoperative patients. Oxaliplatin at fixed 130 mg/m2 on day 1. from 1 14 3-week cycle and...
Obesity and insulin resistance are frequently associated with type 2 diabetes (T2D). Evidence is now revealed that plasma free fatty acid (FFA) levels often elevated in most T2D patients, this can cause peripheral directly. As a result, these FFAs inhibit insulin-stimulated glucose uptake, thus contributing to the onset of insufficient energy within cells. Among various T2D-related complications, continuously loss muscle one important adverse effects. Blocked signaling skeletal manifested by...
The effectiveness and side effects of Type 2 diabetes (T2D) medication are related to individual genetic background. SNPs CYP3A4 CYP2C19 were introduced machine-learning models improve the performance T2D prediction. Two multilabel classification models, ML-KNN WRank-SVM, trained with clinical data CYP3A4/CYP2C19 evaluated. Prediction was evaluated Hamming loss, one-error, coverage, ranking loss average precision. precision WRank-SVM using 92.74% 92.9%, respectively. Combined CYP2C19*2*3,...
Evidence is now revealed that the cytotoxic effect caused by elevated levels of plasma glucose and free fatty acids, also called as glucolipotoxicity, particularly harmful for pancreatic β-cell. In fact, mammalian Ste20-like kinase 1 (MST1) can mediate glucolipotoxicity-induced β-cell damages degradation duodenal homeobox (PDX-1), which known to play an essential role in maintaining function survival. Interestingly, activation pluripotency-related microRNA cluster miR-302 protect β-cells...
Hepatic insulin resistance is associated with metabolic disorders such as type 2 diabetes (T2D), which often develops after the accumulation of lipids in liver. In particular, elevated plasma levels free fatty acids (FFA) are primary sources hepatic lipid that contributes to development insulin-resistant states. Interestingly, one gut-derived incretin hormone receptor called glucagon-like peptide 1 (GLP-1) receptor, highly expressed on human hepatocytes. Although GLP-1-based therapies have...