A5049027774- Renin-Angiotensin System Studies
- COVID-19 Clinical Research Studies
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Cardiac Ischemia and Reperfusion
- Metal and Thin Film Mechanics
- SARS-CoV-2 and COVID-19 Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Educational Technology and Assessment
- Occupational and environmental lung diseases
- MicroRNA in disease regulation
- Cardiac electrophysiology and arrhythmias
- Nitric Oxide and Endothelin Effects
- High-Temperature Coating Behaviors
- Neuroscience of respiration and sleep
- Advanced MRI Techniques and Applications
- Pulmonary Hypertension Research and Treatments
- Sulfur Compounds in Biology
- Cancer, Hypoxia, and Metabolism
- Advanced materials and composites
- Respiratory Support and Mechanisms
- Acute Kidney Injury Research
- Ultrasound and Hyperthermia Applications
- Innovative Educational Techniques
- Heart Failure Treatment and Management
Huadong Hospital
2025
Fudan University
2022-2025
Pudong Medical Center
2022-2025
North China University of Science and Technology
2013-2024
Wuhan No.1 Hospital
2021-2024
Wuhan Prevention and Treatment Center for Occupational Diseases
2024
Hunan Provincial Center for Disease Control and Prevention
2022
Chinese Academy of Medical Sciences & Peking Union Medical College
2018-2020
Institute of Laboratory Animal Science
2020
Emory University
2019
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic poses an unprecedented public health crisis. Evidence suggests that SARS-CoV-2 infection causes dysregulation of the immune system. However, unique signature early responses remains elusive. We characterized transcriptome rhesus macaques and mice infected with SARS-CoV-2. Alarmin S100A8 was robustly induced in SARS-CoV-2-infected animal models as well COVID-19 patients. Paquinimod, a specific inhibitor S100A8/A9, could...
Progressive tissue fibrosis is a cause of major morbidity and mortality. Pulmonary an epithelial-mesenchymal disorder in which TGF-β1 plays central role pathogenesis. Here we show that follistatin-like 1 (FSTL1) differentially regulates TGF-β bone morphogenetic protein signaling, leading to epithelial injury fibroblast activation. Haplodeletion Fstl1 mice or blockage FSTL1 with neutralizing antibody reduced bleomycin-induced vivo. induced response lung promotes the accumulation...
Abstract Background Randomized controlled trials confirm that risks of residual cholesterol and inflammation remains in patients with cardiovascular disease (CVD) even after lipid-lowering therapy. This study aims to investigate the association between dual risk all-cause mortality a real-world population CVD. Methods Patients CVD history who first took statins 1 January 2010 31 December 2017 Kailuan Study were selected as participants. According low-density lipoprotein (LDL-C)...
Over-proliferation of mesangial cells (MCs) is one the main pathological changes in early stages diabetic kidney disease (DKD). Roxadustat, an oral hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitor, widely studied different models disease. Whether roxadustat has beneficial effect on proliferation MCs and DKD remains unknown. The optimal concentration for inhibiting MC was determined using CCK-8 colony formation assays. Changes cell cycle were detected flow cytometry, cycle-related...
The mechanism of acute lung injury (ALI) following limb ischemia-reperfusion (LIR) is not yet clear. We speculate that the unbalanced expression angiotensin-converting enzymes (ACE and ACE2) angiotensins [Ang II Ang-(1-7)] in renin-angiotensin system (RAS) a major cause ALI. To prove this hypothesis, pathological changes, edema, permeability wild-type mice at different time points within 12 h reperfusion after 2 hind-limb ischemia were first detected by morphological method, measurements...
Objective The ratio of uric acid to high-density lipoprotein cholesterol (UHR) was related the risk chronic kidney disease (CKD), we aimed investigate association cumulative UHR (cumUHR) with incidence and progression CKD. Methods Our study included a total 49,913 participants (mean age 52.57 years, 77% males) from Kailuan Study conducted between 2006 2018. Participants who completed three consecutive physical examinations were included. Cumulative computed as summed average two...
Importance Although a high body mass index (BMI) has been found to be associated with increased risk of cardiac conduction block (CCB) in older adults, no further studies have investigated the association between obesity and CCB general population. Objective To investigate CCB, including its subtypes. Design, Setting, Participants This cohort study used data from participants Kailuan Study China (2006-2018) who had completed physical examination 2006 (baseline) not experienced before...
The role of angiotensin-converting enzyme 2 (ACE2) in silicosis remains unknown, although previous studies have suggested that ACE2 may be beneficial. We, therefore, investigated the effect on silicosis, particularly with regard to its regulating epithelial-mesenchymal transition (EMT) induced by silica, aim uncover a new potential target for treatment pulmonary fibrosis.We employed wild-type mice treated diminazene aceturate (DIZE, an activator, 15 mg/kg/day 4 weeks), hACE2-transgenic...
The present study aimed to explore the influence of sirtuin 1 (SIRT1) polymorphisms (rs12778366 and rs3758391) on diabetic foot (DF) susceptibility severity in patients with type 2 diabetes mellitus (T2DM). This case–control recruited 142 DF, 148 T2DM, healthy controls. SIRT1 gene were sequenced by polymerase chain reaction (PCR) direct sequencing method. relative expression mRNA was estimated using quantitative real-time PCR (qRT-PCR) assay. Odds ratio (OR) 95% confidence interval (95% CI)...
ABSTRACT Background: Sepsis-induced acute kidney injury (SI-AKI) is a kind of dysfunction, which brings lot suffering. This study aimed to figure out the role miR-218-5p/PGC-1α axis in SI-AKI. Methods: AKI mouse model was established through cecal ligation and puncture. PGC-1α expression activated using an activator ZLN005 before serum tissue samples were collected. Next, pathological structure apoptosis tissues observed. Levels blood urea nitrogen, creatinine, indicators inflammation...
The aim of this study was to investigate the protective role erythropoietin (EPO) against myocardial fibrosis (MF).Pressure-overloaded rats were established by abdominal aortic constriction, randomly divided in a double-blind manner into 3 groups (n = 12 for each group): sham-operated (sham), operated receiving physiological saline (vehicle) and 4,000 U/kg rhEPO (EPO group). vehicle drugs administered intraperitoneal injection. In addition, cultured adult rat cardiac fibroblasts (CFs)...
Recent genome-wide association studies identified 11 risk loci in different populations of familial and sporadic Parkinson's disease (PD) patients.Few have been verified European Asian populations.We also validated 2 new single-nucleotide polymorphisms, rs947211 rs823144, PARK16 to explore their with susceptibility PD the Xinjiang Uygur Han populations.This case-control study included 312 patients (130 182 Han) 359 control subjects (179 180 Han).Polymerase chain reaction-restriction fragment...